Results 81 to 90 of about 90,894 (265)

Identification of a potent PCNA‐p15‐interaction inhibitor by autodisplay‐based peptide library screening

Microbial Biotechnology
Proliferating cell nuclear antigen (PCNA) is an essential factor for DNA metabolism. The influence of PCNA on DNA replication and repair, combined with the high expression rate of PCNA in various tumours renders PCNA a promising target for cancer therapy.
Sarah Hardebeck, Natalie Jácobo Goebbels, Caroline Michalski, Sebastian Schreiber, Joachim Jose   +4 more
doaj   +1 more source

Dynamic cofilin phosphorylation in the control of lamellipodial actin homeostasis [PDF]

, 2007
During animal cell chemotaxis, signalling at the plasma membrane induces actin polymerisation to drive forward cell movement. Since the cellular pool of actin is limited, efficient protrusion formation also requires the coordinated disassembly of pre ...
Baum, B, Jovceva, E, Larsen, MR, Timms, JF, Waterfield, MD   +4 more
core  

Oxytocin is implicated in social memory deficits induced by early sensory deprivation in mice [PDF]

, 2016
Acknowledgements We thank Miss Jia-Yin and Miss Yu-Ling Sun for their help in breading the mice. Funding This work was supported by grants from the National Natural Science Foundation of China (81200933 to N.-N. Song; 81200692 to L.
Chen, Ling, Ding, Yu-Qiang, Huang, Ying, Lang, Bing, Lv, Zhu-Man, Niu, Xue-Yuan, Pruski, Michal, Qi, Cong-Cong, Shao, Can-Can, Song, Ning-Ning, Zhang, Chan, Zhang, Jin-Bao   +11 more
core   +2 more sources

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Temporal Interference Stimulation Enhances Neural Regeneration

Advanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressott, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo‐Lara, Bethany Geary, Elena Faillace, Shirine Merlo‐Nikpay Aslie, Marcelina Wojewska, Maria Otero‐Jimenez, Martina Genta, Luqiao Tan, Karen Duff, Javier Alegre‐Abarrategui, Rylie Green, Nir Grossmann   +15 more
wiley   +1 more source

Optimization of macromolecular prodrugs of the antitumor antibiotic adriamycin [PDF]

, 1985
In our earlier work [10] on aminoribosyl-bound prodrugs of adriamycin (ADR) using poly(α-l-glutamic acid) (PGA) grafted in high yield (90–100 mol.%) with various peptide spacers as a plasma-soluble macromolecular carrier we observed rather low cytotoxic ...
Feijen, J., Greve, J., Grooth, B.G. de, Heeswijk, W.A.R., Hoes, C.J.T., Mud, J., Potman, W.   +6 more
core   +2 more sources

Peptide Receptor‐Functionalized AuNP‐Embedded Zwitterionic Biopolymeric Nanohydrogel for Electrochemical Sclerostin Sensing

Advanced Science, EarlyView.
We report an electrochemical biosensor that employs biopanning‐derived affinity peptides as selective receptors on a multifunctional chitosan–zwitterionic–gold nanoparticle (CS–ZI–AuNPs) nanohydrogel interface. The CS–ZI–AuNPs nanohydrogel exhibits antifouling properties, abundant sites for stable peptide immobilization, and efficient electrochemical ...
Hyo Jeong Yang, Jae Hwan Shin, Mingi Jo, Changyeon Lee, Hyunmin Yi, Al‐Montaser Bellah H. Ali, Jong Pil Park   +6 more
wiley   +1 more source

A Virus‐Inducible E3–RLCK–MADS Module Coordinates Suppression of Plant Immunity and Fertility in Rice

Advanced Science, EarlyView.
ABSTRACT Viruses often hijack host developmental programs to promote infection, but the mechanistic links between reproductive regulation and antiviral immunity remain incompletely understood. Here, we identify a virus‐triggered hierarchical degradation cascade that links antiviral immunity and fertility regulation in rice. We show that the rice grassy
Yuansheng Wu, Fengling Wu, Shiting Huang, Denglu Yang, Xin Lei, Xue Zhang, Na Liu, Peng Gan, Chuan Li, Jie Zhang, Ming Wu, Qingxiao Jia, Shanshan Zhao, Jianguo Wu   +13 more
wiley   +1 more source

p3 peptide, a truncated form of Aβ devoid of synaptotoxic effect, does not assemble into soluble oligomers [PDF]

FEBS Letters, 2008
In previously proposed models of Aβ soluble oligomers, the N‐terminal domain Aβ1–16, which is missing in p3 peptides, protects the hydrophobic core of the oligomers from the solvent. Without this N‐terminal part, oligomers of p3 peptides would likely expose hydrophobic residues to water and would consequently be less stable.
Dulin, Fabienne, Leveillé, Frederic, Becerril Ortega, Javier, Mornon, Jean-Paul, Buisson, Alain, Callebaut, Isabelle, Colloc'H, Nathalie   +6 more
openaire   +4 more sources

Sampling Strategy: An Overlooked Factor Affecting Artificial Intelligence Prediction Accuracy of Peptides’ Physicochemical Properties

Advanced Intelligent Discovery, EarlyView.
This study reveals that sampling strategy (i.e., sampling size and approach) is a foundational prerequisite for building accurate and generalizable AI models in peptide discovery. Reaching a threshold of 7.5% of the total tetrapeptide sequence space was essential to ensure reliable predictions.
Meiru Yan, Ankeer Abuduhebaier, Haojin Zhou, Jiaqi Wang   +3 more
wiley   +1 more source