Results 71 to 80 of about 90,894 (265)

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Human microbiome-derived peptide affects the development of experimental autoimmune encephalomyelitis via molecular mimicryResearch in context

EBioMedicine
Summary: Background: Gut commensal microbiota has been identified as a potential environmental risk factor for multiple sclerosis (MS), and numerous studies have linked the commensal microorganism with the onset of MS. However, little is known about the
Xin Ma, Jian Zhang, Qianling Jiang, Yong-Xin Li, Guan Yang   +4 more
doaj   +1 more source

Coordinated increase of γ-secretase reaction products in the plasma of some female Japanese sporadic Alzheimer's disease patients: quantitative analysis of p3-Alcα with a new ELISA system

Molecular Neurodegeneration, 2011
Background Aggregatable amyloid β-peptide (Aβ) and non-aggregatable p3-Alcα are metabolic products of the γ-secretase cleavage of amyloid β-protein precursor (APP) and Alcadeinα (Alcα), respectively.
Konno Tomoko, Hata Saori, Hamada Yukiko, Horikoshi-Sakuraba Yuko, Nakaya Tadashi, Saito Yuhki, Yamamoto Tohru, Yamamoto Takayuki, Maeda Masahiro, Ikeuchi Takeshi, Gandy Sam, Akatsu Hiroyasu, Suzuki Toshiharu   +12 more
doaj   +1 more source

Illumination of PRRSV Cytotoxic T Lymphocyte Epitopes by the Three-Dimensional Structure and Peptidome of Swine Lymphocyte Antigen Class I (SLA-I)

Frontiers in Immunology, 2020
To investigate CTL epitope applications in swine, SLA-1*1502-restricted peptide epitopes matching porcine reproductive and respiratory syndrome virus (PRRSV) strains were explored by crystallography, biochemistry, and the specific pathogen-free (SPF ...
Xiaocheng Pan, Xiaocheng Pan, Nianzhi Zhang, Xiaohui Wei, Yinan Jiang, Rong Chen, Qirun Li, Ruiying Liang, Lijie Zhang, Lizhen Ma, Chun Xia, Chun Xia   +11 more
doaj   +1 more source

Mean-Field HP Model, Designability and Alpha-Helices in Protein Structures

, 1999
Analysis of the geometric properties of a mean-field HP model on a square lattice for protein structure shows that structures with large number of switch backs between surface and core sites are chosen favorably by peptides as unique ground states ...
A. Irbäck, A. Irbäck, A. Radzicka, B. L. Hao, C. Anfinsen, C. Chothia, C. H. Hsieh, C. T. Shih, D. J. Lipman, E. D. Nelson, E. D. Nelson, E. I. Shakhnovich, E. I. Shakhnovich, H. C. Lee, H. Li, H. Li, H. Li, H. Nymeyer, H. S. Chan, H. S. Chan, H. S. Chan, J. D. Bryngleson, J. F. Gwan, K. A. Dill, K. W. Plaxco, L. Holm, L. Holm, L. Holm, M. Cieplak, M. R. Ejtehadi, M. R. Garey, N. E. G. Buchler, O. Keskin, P. G. Wolynes, S. Govindarajan, S. Govindarajan, S. Miyazawa, S. S. Plotkin, S. Williams, V. Munõz, Z. Y. Su   +40 more
core   +1 more source

Dramatic expansion of the black widow toxin arsenal uncovered by multi-tissue transcriptomics and venom proteomics. [PDF]

, 2014
BackgroundAnimal venoms attract enormous interest given their potential for pharmacological discovery and understanding the evolution of natural chemistries.
Ayoub, Nadia A, Clarke, Thomas H, Garb, Jessica E, Haney, Robert A, Hayashi, Cheryl Y   +4 more
core   +2 more sources

Genetic Control of Tissue Remodeling by a Non‐Coding SNP in ITGA8 Explains Carotenoid‐Based Color Polymorphism in Marine Mollusks

Advanced Science, EarlyView.
In this study, the orange‐muscle giant abalone (Haliotis gigantea) is used as a model to identify a non‐coding SNP that disrupts the interaction between ITGA8 pre‐mRNA and the splicing factor ILF2, leading to altered ITGA8 splicing. These splicing changes promote carotenoid accumulation in abalone muscle through the regulation of tissue remodeling ...
Xiaohui Wei, Wenzhu Peng, Zekun Huang, Bingye Yang, Yiyu Wu, Minzhen Han, Yi Wang, Bingling Peng, Guosheng Hu, Jiawei Hong, Guijia Liu, Linwei Nie, Yang Gan, Miaoqin Huang, Xuan Luo, Weiwei You, Wen Liu, Caihuan Ke   +17 more
wiley   +1 more source

Isolation and Characterization of Collagen and Antioxidant Collagen Peptides from Scales of Croceine Croaker (Pseudosciaena crocea)

Marine Drugs, 2013
Acid soluble collagen (ASC) from scales of croceine croaker (ASC-C) was successfully isolated with the yield of 0.37% ± 0.08% (dry weight basis), and characterized as type I collagen on the basis of amino acid analysis and electrophoretic pattern.
Bin Wang, Yu-Mei Wang, Chang-Feng Chi, Hong-Yu Luo, Shang-Gui Deng, Jian-Yin Ma   +5 more
doaj   +1 more source

Supplementation of black soldier fly (Hermetia illucens) on productivity and blood hematology

Jurnal Ilmu-Ilmu Peternakan, 2020
Black Soldier Fly larvae are natural antibiotics. The use of methanol extract in BSF larvae has a dual function, namely high protein content and high antibiotic content to kill Gram-negative bacteria.
Andri Cahya Irawan, Dewi Apri Astuti, I Wayan Teguh Wibawan, Widya Hermana   +3 more
doaj   +1 more source

Inhibiting cGAS‐STING to Preserve Mitochondrial–Nuclear Communication and Stemness in Young Tendon Stem Cells: A Hydrogel Strategy against Age‐Related Tendinopathy

Advanced Science, EarlyView.
A dual‐targeting strategy to rejuvenate aged tendons. A reactive oxygen species (ROS)‐responsive hydrogel co‐delivers a selenium nanozyme (scavenges ROS) and a STING inhibitor to tendon stem cells. This combined action restores mitochondria–nucleus communication, alleviates cellular senescence, and rejuvenates tendon regeneration, offering a novel ...
Zhuo Zhang, Weiyong Song, Heng Yin, Yi Wang, Yi Zou, Yuling Li, Yue Luo, Chao Xiang, Xiaoqin Liu, Yan Xiong, Yong Wang, Ke Jiang   +11 more
wiley   +1 more source