Results 31 to 40 of about 90,894 (265)

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source

B-CD8+ T Cell Interactions in the Anti-Idiotypic Response against a Self-Antibody

Journal of Immunology Research, 2017
P3 is a murine, germline, IgM mAb that recognizes N-glycolylated gangliosides and other self-antigens. This antibody is able to induce an anti-idiotypic IgG response and B-T idiotypic cascade, even in the absence of any adjuvant or carrier protein.
Darel Martínez, Amaury Pupo, Lianet Cabrera, Judith Raymond, Nichol E. Holodick, Ana María Hernández   +5 more
doaj   +1 more source

Ultrasonic-assisted Ezymatic Hydrolysis of Peanut Protein to Prepare α-Amylase Inhibitory Peptide

Shipin gongye ke-ji, 2022
In this paper, peanut protein was extracted from peanut meal by alkaline solution and acid precipitation. The content of peanut protein was 87.7% by Kjeldahl method. Peanut polypeptides were prepared by ultrasonic-assisted enzymatic method.
Jinxin TANG, Gaofei YOU, Qiuyang LI, Ping XU, Shiwei LIU, Lei YU, Yunfeng BI   +6 more
doaj   +1 more source

Amyloid-β and APP deficiencies cause severe cerebrovascular defects: important work for an old villain. [PDF]

PLoS ONE, 2013
Alzheimer's disease (AD) is marked by neuritic plaques that contain insoluble deposits of amyloid-β (Aβ), yet the physiological function of this peptide has remained unclear for more than two decades.
Salvadore Luna, D Joshua Cameron, Douglas W Ethell   +2 more
doaj   +1 more source

Expression in Escherichia coli of a cloned DNA sequence encoding the pre-S2 region of hepatitis B virus [PDF]

, 1985
A DNA sequence encoding the entire pre-S2 region (amino acids 120-174; serotype ayw) of human hepatitis B virus envelope protein has been inserted into the lacZ gene of the plasmid pSKS105 yielding a recombinant, pWS3.
Acs, George, Christman, Judith K., Kent, Stephen B. H., Neurath, A. Robert, Offensperger, Wolf, Price, Peter, Strick, Nathan, Wahl, Silke   +7 more
core   +1 more source

Multiple γ-secretase product peptides are coordinately increased in concentration in the cerebrospinal fluid of a subpopulation of sporadic Alzheimer’s disease subjects

Molecular Neurodegeneration, 2012
Background Alcadeinα (Alcα) is a neuronal membrane protein that colocalizes with the Alzheimer's amyloid-β precursor protein (APP). Successive cleavage of APP by β- and γ-secretases generates the aggregatable amyloid-β peptide (Aβ), while cleavage of APP
Hata Saori, Taniguchi Miyako, Piao Yi, Ikeuchi Takeshi, Fagan Anne M, Holtzman David M, Bateman Randall, Sohrabi Hamid R, Martins Ralph N, Gandy Sam, Urakami Katsuya, Suzuki Toshiharu   +11 more
doaj   +1 more source

Vasoactive intestinal peptide–VIPR2 signaling regulates tumor cell migration

Frontiers in Oncology, 2022
Phosphoinositide metabolism is critically involved in human cancer cell migration and metastatic growth. The formation of lamellipodia at the leading edge of migrating cells is regulated by metabolism of the inositol phospholipid PI(4,5)P2 into PI(3,4,5 ...
Satoshi Asano, Satoshi Asano, Misa Yamasaka, Kairi Ozasa, Kotaro Sakamoto, Atsuko Hayata-Takano, Atsuko Hayata-Takano, Takanobu Nakazawa, Takanobu Nakazawa, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, Hitoshi Hashimoto, James A. Waschek, Yukio Ago, Yukio Ago   +16 more
doaj   +1 more source

Apex Peptide Elution Chain Selection: A New Strategy for Selecting Precursors in 2D-LC-MALDI-TOF/TOF Experiments on Complex Biological Samples [PDF]

, 2010
LC-MALDI provides an often overlooked opportunity to exploit the separation between LC-MS and MS/MS stages of a 2D-LC-MS-based proteomics experiment, that is, by making a smarter selection for precursor fragmentation. Apex Peptide Elution Chain Selection
Breitling, Rainer,, Fusetti, Fabrizia,, Gandhi, Tejas,, Permentier, Hjalmar P.,, Poolman, Bert,, Wiederhold, Elena,   +5 more
core   +3 more sources

Study of the Antihypertensive Peptides Derived from Alpha-Lactalbumin Hydrolysate after Simulation of Digestion

Biology and Life Sciences Forum, 2022
Alpha-lactalbumin is a whey protein that is a cheese-making industrial residue of high biological value. The antihypertensive capacity of three peptides obtained from the simulated gastrointestinal digestion of alpha-lactalbumin hydrolysates was studied.
Antonella Alba, Jessica Báez, Adriana Maite Fernández-Fernández, Agustina Nardo, María Cristina Añón, Alejandra Medrano, Margot Paulino   +6 more
doaj   +1 more source

Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates [PDF]

, 2013
Antibiotic resistance is one of the main problems concerning public health or clinical practice. Antimicrobial peptides appear as good candidates for the development of new therapeutic drugs.
Corso, Alejandra, Faccone, Diego Francisco, Maffia, Paulo Cesar, Martínez, Melina María Belén, Noguera, Martín Ezequiel, Payés, Cristian, Semorile, Liliana Carmen, Veliz, Omar   +7 more
core   +1 more source