Results 41 to 50 of about 90,894 (265)

An LRP1-binding motif in cellular prion protein replicates cell-signaling activities of the full-length protein

JCI Insight, 2023
Low-density lipoprotein receptor-related protein-1 (LRP1) functions as a receptor for nonpathogenic cellular prion protein (PrPC), which is released from cells by ADAM (a disintegrin and metalloproteinase domain) proteases or in extracellular vesicles ...
Elisabetta Mantuano, Carlotta Zampieri, Pardis Azmoon, Cory B. Gunner, Kyle R. Heye, Steven L. Gonias   +5 more
doaj   +1 more source

Identification of the Plasticity-Relevant Fucose-α(1−2)-Galactose Proteome from the Mouse Olfactory Bulb [PDF]

, 2009
Fucose-α(1−2)-galactose [Fucα(1−2)Gal] sugars have been implicated in the molecular mechanisms that underlie neuronal development, learning, and memory. However, an understanding of their precise roles has been hampered by a lack of information regarding
Domino, Steven E., Ficarro, Scott B., Hsieh-Wilson, Linda C., Krishnamurthy, Chithra, Murrey, Heather E., Peters, Eric C.   +5 more
core   +4 more sources

Extraction and Identification of Three New Urechis unicinctus Visceral Peptides and Their Antioxidant Activity

Marine Drugs, 2022
The viscera of Urechis unicinctus with polypeptides, fatty acids, and amino acids are usually discarded during processing to food. In order to improve the utilization value of the viscera of Urechis unicinctus and avoid resource waste, antioxidant ...
Jingjing Li, Jiajun Lu, Charles Asakiya, Kunlun Huang, Xiuzhi Zhou, Qingliang Liu, Xiaoyun He   +6 more
doaj   +1 more source

An exploration of angiotensin-converting enzyme (ACE) inhibitory peptides derived from gastrointestinal protease hydrolysate of milk using a modified bioassay-guided fractionation approach coupled with in silico analysis

Journal of Dairy Science, 2022
: An improved bioassay-guided fractionation was performed to effectively screen angiotensin-I converting enzyme inhibitory (ACEI) peptides from milk protein hydrolysate.
Sugiyati Ningrum, Aji Sutrisno, Jue-Liang Hsu   +2 more
doaj   +1 more source

Donor-strand exchange in chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics [PDF]

, 2008
Adhesive multi-subunit fibres are assembled on the surface of many pathogenic bacteria via the chaperone-usher pathway. In the periplasm, a chaperone donates a β-strand to a pilus subunit to complement its incomplete immunoglobulin-like fold.
Ashcroft, A.E., Paci, E., Radford, S.E., Rose, R.J., Waksman, G., Welsh, T.S.   +5 more
core   +1 more source

Structural characterization of peroxyl radical oxidative products of antioxidant peptides from hydrolyzed proteins

Heliyon
This work aimed to characterize oxidative products of five unique antioxidant peptides (P1: YFDEQNEQFR, P2: GQLLIVPQ, P3: SPFWNINAH, P4: NINAHSVVY, P5: RALPIDVL) from hydrolyzed oat proteins.
Ramak Esfandi, William G. Willmore, Apollinaire Tsopmo   +2 more
doaj   +1 more source

Furin targeted drug delivery for treatment of rhabdomyosarcoma in a mouse model. [PDF]

PLoS ONE, 2010
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Improvement of treatment efficacy and decreased side effects through tumor-targeted drug delivery would be desirable.
Katarina Hajdin, Valentina D'Alessandro, Felix K Niggli, Beat W Schäfer, Michele Bernasconi   +4 more
doaj   +1 more source

Psoralen and ultraviolet A light treatment directly affects phosphatidylinositol 3-kinase signal transduction by altering plasma membrane packing [PDF]

, 2016
Psoralen and ultraviolet A light (PUNTA) are used to kill pathogens in blood products and as a treatment of aberrant cell proliferation in dermatitis, cutaneous T-cell lymphoma, and graft versus-host disease.
Compernolle, Veerle, Devloo, Rosalie, Feys, Hendrik, Sandra, Koen, t'Kindt, Ruben, Van Aelst, Britt, Vandekerckhove, Philippe, Zachée, Pierre   +7 more
core   +2 more sources

Positional scanning and computational modeling reveal determinants of legumain transpeptidase activity. [PDF]

Protein Sci
Abstract Legumain is a lysosomal cysteine protease that plays a central role in antigen processing for MHC class II presentation. Beyond its canonical proteolytic activity, legumain can also function as a peptide ligase or transpeptidase. This non‐canonical activity becomes particularly relevant under pathophysiological conditions such as cancer and ...
Klaushofer R, Dahms SO, Brandstetter H, Dall E.   +3 more
europepmc   +2 more sources

Targeted Mutations in the Fusion Peptide Region of La Crosse Virus Attenuate Neuroinvasion and Confer Protection against Encephalitis

Viruses, 2022
La Crosse virus (LACV) is a major cause of pediatric encephalitis and aseptic meningitis in the Midwestern, Mid-Atlantic, and Southern United States, where it is an emerging pathogen.
Bradley S. Hollidge, Mary-Virginia Salzano, John M. Ibrahim, Jonathan W. Fraser, Valentina Wagner, Nicole E. Leitner, Susan R. Weiss, Friedemann Weber, Francisco González-Scarano, Samantha S. Soldan   +9 more
doaj   +1 more source