Results 51 to 60 of about 3,933 (119)

Molecular Insights and Therapeutic Innovations in Cervical Cancer: Emerging Drug Targets

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2026, Issue 1, 2026.
Cervical cancer is a significant global health challenge, ranking as the fourth most prevalent cancer among women worldwide. While human papillomavirus infection is the primary cause, the disease’s progression involves complex molecular mechanisms.
Abhijit Debnath, Rajesh Kumar Singh, Rupa Mazumder, Arpita Dua, Pankaj Kumar Tyagi, Anil Kumar Singh, Kuldeep Singh   +6 more
wiley   +1 more source

Human Papillomavirus in Colorectal Cancer: from Molecular Mechanisms to Clinical Implications and Therapeutic Strategies [PDF]

Iranian Journal of Colorectal Research
Colorectal cancer (CRC) is a leading cause of cancer-related mortality, and its incidence is increasing. Althoughthe causes are multifactorial, a growing body of evidence implicates human papillomavirus (HPV) as a potentialcontributor in some cases. This
Pouria Rahemi, Sayyid Ali Hosseini, Mahdieh Hoseinpour, Mahdi Farasati   +3 more
doaj   +1 more source

Whole‐Genome Characterization Reveals High Prevalence of Human Papillomavirus Type 18 Sublineage A1 With Novel Functional Polymorphisms Among Women in Northeastern Brazil

International Journal of Microbiology, Volume 2026, Issue 1, 2026.
Few studies have characterized the complete genome of HPV18. Although incipient, its variant lineages and sublineages have been shown to have a set of polymorphisms associated with distinct risks for the development of high‐grade lesions and cervical cancer.
Anny Beatriz de Oliveira Gama, Sérgio Nolasco dos Santos, Iracy Menezes de Souza Barbosa, Anne Caroline Santos Ramos, Silvio Santana Dolabella, Marcus Vinicius de Aragão Batista, Kai Zheng   +6 more
wiley   +1 more source

Prevalence and Clinical Implications of HPV Infection in Oral Cavity and Oropharynx in HIV+ Men

International Journal of Dentistry, Volume 2026, Issue 1, 2026.
Introduction Human papillomavirus (HPV) is associated with several types of oral lesions (OLs), including oropharyngeal squamous cell carcinoma (SCC), especially in HIV‐positive individuals. Objectives To identify the prevalence and clinical implications of the alpha (α) and beta (β) genera of HPV in the oral cavity and oropharynx of HIV‐positive men ...
José Adán Vizcaíno-Reséndiz, Jaime F. Andrade-Villanueva, Luis Felipe Jave-Suárez, Tonatiuh Abimael Baltazar-Díaz, Felipe De Jesús Bustos-Rodríguez, Luis Eduardo Del Moral-Trinidad, Dana Alejandra Figueroa-González, Juan Carlos Vázquez-Limón, Ana Esther Mercado-González, Luz Alicia González-Hernández, Hannah Wesley   +10 more
wiley   +1 more source

O Papilomavírus Humano: um fator relacionado com a formação de neoplasias

Revista Brasileira de Cancerologia, 2005
Os estudos realizados nos últimos anos, com o auxílio de novas tecnologias de detecção viral, permitem-nos considerar o Papilomavírus Humano (HPV) como o agente causal do câncer do colo de útero.
Rafael Souto, Júlio Pedro Borgo Falhari, Aparecido Divino da Cruz   +2 more
doaj   +1 more source

A Field‐Deployable RotEx‐LAMP‐LFA Platform for Molecular Triage of HPV‐Driven Oncogenesis

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This study presents RotEx‐LAMP‐LFA, a fully integrated, battery‐powered, low‐cost point‐of‐care device for rapid cervical cancer risk detection based on HPV16/18 E6/E7 mRNA. Clinically validated, the system demonstrated high sensitivity and specificity, and showed full concordance between self‐collected and clinician‐collected samples, offering a ...
Yuan Gao, Qiang Wen, Siyuan Qiao, Linyi Deng, Keyue Li, Zhuyan Shao, Xiaonan Liu, Tao Zhu, Chao Zhang, Da Han, Weihong Tan   +10 more
wiley   +1 more source

Exploitation of Biocomputational Approaches for siRNA‐Mediated Gene Silencing of HPV: A Novel Therapeutic Strategy for Cervical Cancer

Cancer Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background With recurrent high‐risk human papillomavirus (HPV) infections, especially HPV16 and HPV18, cervical cancer is the fourth most common disease among women. The functional alterations of the E6 and E7 proteins are essential to the oncogenic process of high‐risk HPVs and cervical cancer development.
Md. Habib Ullah Masum, Rehana Parvin, Homaira Pervin Heema, Aklima Akter, Jannatul Ferdous   +4 more
wiley   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, Volume 599, Issue 21, Page 3012-3028, November 2025.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

HPV-driven cancers: a looming threat and the potential of CRISPR/Cas9 for targeted therapy

Virology Journal
Cervical and other anogenital malignancies are largely caused by E6 and E7 oncogenes of high-risk human papillomaviruses (HPVs), which inhibit important tumor suppressors like p53 and pRb when they are persistently activated. The main goal of traditional
Atefeh Zamani Kermanshahi, Fatemeh Ebrahimi, Ahmad Taherpoor, Narges Eslami, Hossein Bannazadeh Baghi   +4 more
doaj   +1 more source

Hypoxia inducible factor-1 alpha expression is increased in infected positive HPV16 DNA oral squamous cell carcinoma and positively associated with HPV16 E7 oncoprotein

Infectious Agents and Cancer, 2011
Background There is increasing evidence for the role of High Risk (HR) Human PapillomaVirus (HPV) in the pathogenesis of Oral Squamous Cell Carcinoma (OSCC).
Di Fede Olga, Cappello Francesco, Aragona Francesco, Amato Marco C, Arancio Walter, Rodolico Vito, Pannone Giuseppe, Campisi Giuseppina   +7 more
doaj   +1 more source