Results 11 to 20 of about 905,362 (332)

Drugging p53 in cancer: one protein, many targets

Nature reviews. Drug discovery, 2022
Tumour suppressor gene TP53 is frequently mutated in cancer, and therapeutic strategies to restore the functionality of p53 in tumours have been pursued for decades without success. This Review discusses the promising approaches towards p53-based therapy
Ori Hassin, M. Oren
semanticscholar   +1 more source

Analysis of Adenoviral p53 Gene Therapy Clinical Trials in Recurrent Head and Neck Squamous Cell Carcinoma

Frontiers in Oncology, 2021
BackgroundWe conducted an analysis of previous adenoviral p53 (Ad-p53) treatment data in recurrent head and neck squamous cell carcinoma (HNSCC) patients to identify optimal Ad-p53 treatment methods for future clinical trials.MethodsThe analysis involved
Robert E. Sobol, Kerstin B. Menander, Sunil Chada, Dora Wiederhold, Beatha Sellman, Max Talbott, John J. Nemunaitis   +6 more
doaj   +1 more source

p53 signaling in cancer progression and therapy

Cancer Cell International, 2021
The p53 protein is a transcription factor known as the "guardian of the genome" because of its critical function in preserving genomic integrity. The TP53 gene is mutated in approximately half of all human malignancies, including those of the breast ...
H. Marei, A. Althani, N. Afifi, A. Hasan, T. Caceci, G. Pozzoli, A. Morrione, A. Giordano, C. Cenciarelli   +8 more
semanticscholar   +1 more source

Tumor-Targeted Delivery of the p53-Activating Peptide VIP116 with PEG-Stabilized Lipodisks

Nanomaterials, 2020
Stapled peptides targeting the interaction between p53 and its negative regulators MDM2 and MDM4 have exhibited great potential as anti-cancer drugs, albeit with room for improvement in formulation and tumor specificity.
Sara Lundsten, Víctor Agmo Hernández, Lars Gedda, Tina Sarén, Christopher J. Brown, David P. Lane, Katarina Edwards, Marika Nestor   +7 more
doaj   +1 more source

Targeting mutant p53 for cancer therapy: direct and indirect strategies

Journal of Hematology & Oncology, 2021
TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 protein oncogenic properties.
Jiahao Hu, Jiasheng Cao, Win Topatana, Sarun Juengpanich, Shijie Li, Bin Zhang, Jiliang Shen, Liu-xin Cai, Xiujun Cai, Mingyu Chen   +9 more
semanticscholar   +1 more source

Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication [PDF]

, 2017
Gain-of-function (GOF) p53 mutations are observed frequently in most intractable human cancers and establish dependency for tumor maintenance and progression.
Beckerman, Bronte, Catherine A. Vaughan, Frum, Lin, Luzhna, Olivier, Oren, Rebecca A. Frum, Shilpa Singh, Steven R. Grossman, Sumitra Deb, Swati Palit Deb, Zeman, Zuazua-Villar   +14 more
core   +2 more sources

Monitoring flux in signalling pathways through measurements of 4EBP1-mediated eIF4F complex assembly

BMC Biology, 2019
Background The most commonly occurring cancer mutations, including oncogenes such as MYC, Ras and PIK3C, are found in signal transductions pathways feeding into the translational machinery.
Yuri Frosi, Rachael Usher, Dawn Thean Gek Lian, David P. Lane, Christopher J. Brown   +4 more
doaj   +1 more source

The Basally Expressed p53-Mediated Homeostatic Function

Frontiers in Cell and Developmental Biology, 2021
Apart from mutations in the p53 gene, p53 functions can be alternatively compromised by a decrease in nuclear p53 protein levels or activities. In accordance, enhanced p53 protein turnover due to elevated expression of the critical p53 E3 ligase MDM2 or ...
Isha Nagpal, Zhi-Min Yuan
doaj   +1 more source

DIMP53-1:A novel small-molecule dual inhibitor of p53-MDM2/X interactions with multifunctional p53-dependent anticancer properties [PDF]

, 2017
The transcription factor p53 plays a crucial role in cancer development and dissemination, and thus, p53-targeted therapies are among the most encouraging anticancer strategies.
Baeriswyl, Burgess, Cordani, Gomes, Graves, Hong, Lee, Li, Lion, Maeda, Pal, Pereira, Powell, Qin, Reed, Soares, Soares, Soares, Spano, Tan, Vassilev, Vasudev, Wade, Weidner   +23 more
core   +2 more sources

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

PLoS Biology, 2008
Cellular senescence suppresses cancer by arresting cell proliferation, essentially permanently, in response to oncogenic stimuli, including genotoxic stress.
Jean-Philippe Coppé, C. Patil, F. Rodier, Yu Sun, Denise P. Muñoz, J. Goldstein, P. Nelson, P. Desprez, J. Campisi   +8 more
semanticscholar   +1 more source