Results 11 to 20 of about 646,683 (270)
Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response. [PDF]
PLoS ONE, 2010 The pro-apoptotic function of p53 has been well defined in preventing genomic instability and cell transformation. However, the intriguing fact that p53 contributes to a pro-survival advantage of tumor cells under DNA damage conditions raises a critical ...
Danupon Nantajit +5 more
doaj +17 more sources
Functional display of bioactive peptides on the vGFP scaffold
Scientific Reports, 2021 Grafting bioactive peptides into recipient protein scaffolds can often increase their activities by conferring enhanced stability and cellular longevity. Here, we describe use of vGFP as a novel scaffold to display peptides. vGFP comprises GFP fused to a
Sharon Min Qi Chee +6 more
doaj +1 more source
p53-Induced DNA Bending: The Interplay between p53−DNA and p53−p53 Interactions [PDF]
The Journal of Physical Chemistry B, 2008 Specific p53 binding-induced DNA bending and its underlying responsible forces are crucial for the understanding of selective transcription activation. Diverse p53-response elements exist in the genome; however, it is not known what determines the DNA bending and to what extent.
Yongping, Pan, Ruth, Nussinov
openaire +2 more sources
F1000Research, 2022 Background: The measures taken to contain the COVID-19 pandemic, led to significant changes in university education, resulting in the new normal standard of virtual teaching in many undergraduate medical schools worldwide.
Fiorella Hernandez +4 more
doaj +1 more source
Journal of Nutrition and Metabolism, 2021 Background. Peru has one of the highest infection and death rates in the world for the COVID-19 pandemic. The government implemented house confinement measures with probable consequences on lifestyle, particularly affecting eating habits, physical ...
Salomón Huancahuire-Vega +7 more
doaj +1 more source
Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1:a novel anticancer small-molecule [PDF]
, 2015 Restoration of the p53 pathway, namely by reactivation of mutant (mut) p53, represents a valuable anticancer strategy. Herein, we report the identification of the enantiopure tryptophanol-derived oxazoloisoindolinone SLMP53-1 as a novel reactivator of ...
Bessa, Cláudia +15 more
core +8 more sources
Nature Communications, 2022 Approaches have been devised to increase the discovery rate of intrabodies but often these yield results that aren’t functional in cells. Here the authors engineer and optimise an autonomous and disulphide-free human VH domain for intracellular ...
Yuri Frosi +18 more
doaj +1 more source
Atención Primaria, 2022 Resumen: Objetivo: Elaborar una escala válida y fiable para medir el rol del profesional de enfermería en la comunidad (REFCO). Diseño: Estudio observacional con diseño transversal de tipo instrumental.
Evelyn M. Mamani-Vilca +5 more
doaj +1 more source
Living with p53, Dying of p53 [PDF]
Cell, 2007 The p53 tumor suppressor protein acts as a major defense against cancer. Among its most distinctive features is the ability to elicit both apoptotic death and cell cycle arrest. In this issue of Cell, Das et al. (2007) and Tanaka et al. (2007) provide new insights into the mechanisms that dictate the life and death decisions of p53.
Aylon, Yael, Oren, Moshe
openaire +2 more sources
p53 β-hydroxybutyrylation attenuates p53 activity [PDF]
Cell Death & Disease, 2019 Abstractp53 is an essential tumor suppressor, whose activity is finely tuned by the posttranslational modifications. Previous research has reported that β-hydroxybutyrate (BHB) induces β-hydroxybutyrylation (Kbhb), which is a novel histone posttranslational modification.
Kun Liu +13 more
openaire +2 more sources