Results 71 to 80 of about 646,683 (270)

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Conservative Treatment of HAV-Associated Acalculous Acute Cholecystitis in an Adult: A Case Report

Case Reports in Medicine
Hepatitis A virus (HAV) is a viral infection that can present with a wide range of clinical manifestations, including rare complications such as acute acalculous cholecystitis (AAC). We present the case of a 31-year-old woman who arrived at the emergency
Sebastian A. Medina-Ramirez, Camila A. Arones-Santayana, Eduardo Carcausto Huamani, Nelson Diaz-Reyes   +3 more
doaj   +1 more source

Mdm2 Is Required for Survival and Growth of p53-Deficient Cancer Cells. [PDF]

, 2017
p53 deletion prevents the embryonic lethality of normal tissues lacking Mdm2, suggesting that cells can survive without Mdm2 if p53 is also absent.
Adams, Clare M., Eischen, Christine M., Feeley, Kyle P, Mitra, Ramkrishna   +3 more
core   +1 more source

Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53 independent pathways [PDF]

, 2014
Most cancer cells use aerobic glycolysis to fuel their growth. The enzyme lactate dehydrogenase-A (LDH-A) is key to cancer’s glycolytic phenotype, catalysing the regeneration of nicotinamide adenine dinucleotide (NAD þ ) from reduced nicotinamide adenine
Allison, Simon J., Granchi, C., Knight, J.R.P., Milner, J., Minutolo, F., Phillips, R.M., Rani, R.   +6 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Prognostic value of immunohistochemically detected p53 in adjuvant chemotherapy-treated triple negative breast cancer

Kaohsiung Journal of Medical Sciences, 2018
Mutations of the p53 gene are the most common genomic alterations associated with triple-negative breast cancer (TNBC) and are reported in 60–88% cases. Despite the high incidence of such mutations, there is no consensus about the clinical application of
Soo Youn Bae, Seung Pil Jung, Se Kyung Lee, Jonghan Yu, Jeong Eon Lee, Seok Won Kim, Seok Jin Nam   +6 more
doaj   +1 more source

Insulin receptor tyrosine kinase substrate enhances low levels of MDM2-mediated p53 ubiquitination. [PDF]

PLoS ONE, 2011
The tumor suppressor p53 controls multiple cellular functions including DNA repair, cell cycle arrest and apoptosis. MDM2-mediated p53 ubiquitination affects both degradation and cytoplasmic localization of p53.
Ke-Sheng Wang, Gang Chen, Hai-Lian Shen, Ting-Ting Li, Fei Chen, Qin-Wan Wang, Zhi-Qin Wang, Ze-Guang Han, Xin Zhang   +8 more
doaj   +1 more source

Small molecule induced reactivation of mutant p53 in cancer cells [PDF]

, 2013
The p53 cancer mutant Y220C is an excellent paradigm for rescuing the function of conformationally unstable p53 mutants because it has a unique surface crevice that can be targeted by small-molecule stabilizers.
Adams, Alan R. Fersht, Andreas C. Joerger, Boeckler, Brown, Bullock, Bullock, Chipuk, Chuckowree, Cook, Dearth, Di Como, Emsley, Endo, Foster, Gannon, Green, Hengartner, Irina S. Chuckowree, Jahangir Amin, Joerger, Joerger, Joerger, Joerger, John Spencer, Johnson, Kaar, Kabsch, Kojima, Kojima, Lambert, Lane, Legros, Leslie, Liu, Newhouse, Oda, Petitjean, Rainer Wilcken, Rippin, Speidel, Spencer, Spencer, Spencer, Spencer, Spencer, Taylor, Van Maerken, Vassilev, Villunger, Vousden, Walerych, Wang, Wattel, Wilcken, Wilcken, Wolter, Xiangrui Liu, Yu   +58 more
core   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A truncated p53 in human lung cancer cells as a critical determinant of proliferation and invasiveness

Tumor Biology, 2017
As a transcription factor, p53 must accumulate in the nucleus to be effective. Signals related to nuclear localization are distributed mainly in the C-terminal of p53.
Weiying Li, Baitang Lai, Xuehui Yang, Chunyan Zhang, Hui Wang   +4 more
doaj   +1 more source