Results 231 to 240 of about 101,614 (324)

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study introduces a biomimetic nanoplatform (MTCA@C) designed for precise cancer therapy. It targets mitochondria to induce dysfunction through photodynamic activation, while concurrently blocking mitophagy via lysosomal alkalinization. The platform further triggers methuosis, resulting in tumor cell death through vacuolization and energy pathway ...
Xiao Xu, Qiqing Huang, Yang Liu, Jinzhuo Liu, Deyi Yang, Yanni Song, Xin Han   +6 more
wiley   +1 more source

Rubia cordifolia L. Dichloromethane Extract Ameliorates Contrast-Induced Acute Kidney Injury by Activating Autophagy via the LC3B/p62 Axis. [PDF]

Molecules
Sun X, He K, Chen G, Yang X, Pan X, Liao K.   +5 more
europepmc   +1 more source

Trichinella spiralis inhibits myoblast differentiation by targeting SQSTM1/p62 with a secreted E3 ubiquitin ligase [PDF]

Jian da Pang, Xue min Jin, Yi Liu, Zi jian Dong, Jing Ding, Pascal Boireau, Isabelle Vallée, Ming yuan Liu, Ning Xu, Xiao lei Liu   +9 more
openalex   +1 more source

Targeting the SIRT1‐NAT10‐GABABR1 Axis: A Novel Epitranscriptomic Approach to Mitigate Sevoflurane‐Induced Cognitive Impairment in Aging

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
The study reveals that NAT10 enhances GABABR1 mRNA stability via ac4A modification, leading to excessive inhibitory synaptic activation. In aged rats, sevoflurane contributes to cognitive impairment by inhibiting Sirt1 and neuronal autophagy, which subsequently disrupts energy metabolism.
Xin Xie, Wei Du, Yanmei Zhang, Xiaomin Zhang   +3 more
wiley   +1 more source

CPUK02 sensitizes U87 glioblastoma cell lines to TMZ treatment via autophagy flux inhibition. [PDF]

Mol Biol Res Commun
Rezaie H, Dastghaib S, Siri M, Mokarram P, Hemmati M.   +4 more
europepmc   +1 more source

Tyrosine phosphorylation of Ras GTPase-activating protein stabilizes its association with p62 at membranes of v-Src transformed cells.

, 1993
Soochul Park, Richard Jove
openalex   +1 more source

β‐Asarone Attenuates Neuroinflammation of Alzheimer's Disease by Activating Autophagy and Suppressing NLRP3 Inflammasome Assembly

CNS Neuroscience &Therapeutics, Volume 32, Issue 2, February 2026.
β‐amyloid activates microglia via the TLR/NF‐κB pathway and primes the NLRP3 inflammasome, driving neuroinflammation. β‐asarone counteracts this by activating autophagy, which degrades NLRP3 components and inhibits inflammasome assembly. This reduces IL‐1β maturation, suppresses cytokine release, and alleviates neuronal damage and cognitive deficits in
Zhiwei Xu, Wanying Xu, Jinxin He, Jiahui Qian, Hui Wang, Changyu Li, Xiaojie Zhou   +6 more
wiley   +1 more source

Obestatin Treatment Counteracts Muscle Wasting by Reactivation of Autophagy in Duchenne Muscular Dystrophy. [PDF]

MedComm (2020)
Santos-Zas I, Costas-Abalde S, Lodeiro AC, Fernández-Barreiro F, Cid-Díaz T, Leal-López S, González-Sánchez J, García-Lamela M, Debasa-Corral L, Mosteiro CS, Mamchaoui K, Mouly V, Casabiell X, Gallego R, Relova JL, Pazos Y, Camiña JP.   +16 more
europepmc   +1 more source

Molecular Mechanisms and Therapeutic Potential of DJ‐1 in Skeletal Muscle Homeostasis and Disease

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
DJ‐1 protein functions as a redox‐sensing guardian in skeletal muscle by coordinating antioxidant defense, mitochondrial homeostasis, metabolic adaptation, and anti‐atrophy signaling. Enhancing its function holds promise as a potential therapeutic strategy for muscle atrophy, ALS, and metabolic myopathies.
Yue Zhang, Menghuan Li, Xiaojing Xie, Baokai Tian, Zhenwei Bao, Xuejie Yi   +5 more
wiley   +1 more source

Development of a p62 biodegrader for autophagy targeted degradation. [PDF]

Nat Commun
Thiel Z, Marcellin D, Manneville C, Goretzki B, Egger L, Maher R, Siccardi N, Torres L, Probst A, Müller CS, George N, Vogel M, Sinterhauf S, Lavoisier A, Choi JY, Forcellino L, Landshammer A, Hauck P, Be C, Villard F, Gutmann S, Meyer M, Freuler F, Hinniger A, Fernández C, Chau S, Patoor M, Sansig G, Mitchell G, Nyfeler B.   +29 more
europepmc   +1 more source