Results 1 to 10 of about 6,861 (141)

p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis [PDF]

Nature Communications, 2017
Soluble misfolded proteins that fail to be degraded by the ubiquitin proteasome system (UPS) are redirected to autophagy via specific adaptors, such as p62.
Hyunjoo Cha-Molstad, Zhiwei Feng, Su Hyun Lee   +2 more
exaly   +5 more sources

Immunohistochemical Profile of p62/SQSTM1/Sequestosome‐1 in Human Low‐ and High‐Grade Intracranial Meningiomas

Analytical Cellular Pathology
Among autophagic-related proteins, p62/SQSTM1/Sequestosome-1 represents a relevant actor in cellular proliferation and neoplastic growth. Although, recently, p62 expression has been analyzed in different neurodegenerative and glial neoplastic diseases ...
Giovanni Tuccari, Guido Fadda, Maurizio Martini   +2 more
exaly   +5 more sources

Selective Autophagy Receptor p62/SQSTM1, a Pivotal Player in Stress and Aging

Frontiers in Cell and Developmental Biology, 2022
Efficient proteostasis is crucial for somatic maintenance, and its decline during aging leads to cellular dysfunction and disease. Selective autophagy is a form of autophagy mediated by receptors that target specific cargoes for degradation and is an ...
Anita V Kumar, Joslyn Mills, Louis R Lapierre   +2 more
exaly   +3 more sources

Tumorigenesis in tuberous sclerosis complex is autophagy and p62/sequestosome 1 (SQSTM1)-dependent. [PDF]

Proc Natl Acad Sci U S A, 2011
Tuberous sclerosis complex (TSC) is a tumor suppressor syndrome characterized by benign tumors in multiple organs, including the brain and kidney. TSC-associated tumors exhibit hyperactivation of mammalian target of rapamycin complex 1 (mTORC1), a direct inhibitor of autophagy. Autophagy can either promote or inhibit tumorigenesis,
Parkhitko A, Myachina F, Morrison TA, Hindi KM, Auricchio N, Karbowniczek M, Wu JJ, Finkel T, Kwiatkowski DJ, Yu JJ, Henske EP.   +10 more
europepmc   +4 more sources

Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis

Cell Death and Disease
Alterations in the dopamine catabolic pathway are known to contribute to the degeneration of nigrostriatal neurons in Parkinson’s disease (PD). The progressive cellular buildup of the highly reactive intermediate 3,4-dihydroxyphenylacetaldehye (DOPAL ...
Anna Masato, Annapaola Andolfo, Giulia Favetta, Edoardo Niccolò Bellini, Susanna Cogo, Luisa Dalla Valle, Daniela Boassa, Elisa Greggio, Nicoletta Plotegher, Luigi Bubacco   +9 more
doaj   +4 more sources

NSUN2 mediated-aberrant 5-methylcytosine methylation regulates autophagy-related ferroptosis in oral squamous cell carcinoma progression [PDF]

Cell Death and Disease
Oral squamous cell carcinoma (OSCC) is a common malignant tumor with high metastasis rates and poor prognosis. This study investigated the role of NOP2/Sun RNA methyltransferase family member 2 (NSUN2), a key 5-methylcytosine (m5C) methyltransferase, and
Yunyang Lu, Runze Li, Weidong Du, Jie Wu, Yi He, Lingyu Yuan, Xun Chen, Shiyu Lv, Fangyang Shi, Jiajun Hu, Wei Zhao, Dongsheng Yu   +11 more
doaj   +2 more sources

Sequestering sequestosome 1 via S-acylation in autophagy, Huntington disease, and beyond [PDF]

Autophagy Reports
Protein mislocalization and aggregation are hallmark features in neurodegeneration. As proteins mislocalize, proteostasis deficiency and protein aggregation typically follow.
Y Alshehabi, F Abrar, D.D.O Martin
doaj   +2 more sources

Mature‐onset obesity in p62‐deficient male mice maintains skeletal muscle mass despite metabolic dysfunction [PDF]

Physiological Reports
Sequestosome 1 (p62/SQSTM1) is a multifunctional scaffolding protein at the intersection of autophagy and metabolic regulation. While p62 deficiency causes mature‐onset obesity and insulin resistance, its effects on skeletal muscle mass and function ...
Do‐Houn Kim, Gloria Salazar, Alex Klemp, Hyun‐Seok Hwang, Mingchia Yeh, Lynn B. Panton, Jeong‐Su Kim   +6 more
doaj   +2 more sources

SQSTM1/p62 at the Crossroads of Autophagy, Inflammation, and Lethal Infection [PDF]

Cells
Sequestosome 1 (SQSTM1, also known as p62) has emerged as a multifunctional signaling adaptor that bridges autophagy, proteostasis, and inflammation. In this review, we discuss the molecular mechanisms by which SQSTM1 regulates selective autophagy and ...
Ruoxi Zhang, Rui Kang, Daolin Tang
doaj   +2 more sources

The multifaceted role of SQSTM1/p62 in disc degeneration: A master regulator of cellular stress responses [PDF]

Biochemistry and Biophysics Reports
Intervertebral disc degeneration (IDD) is a key contributor to lumbar degenerative diseases and chronic low back pain. Accumulating evidence indicates that Sequestosome 1 (SQSTM1/p62), a multifunctional adaptor protein, plays a pivotal role in IDD ...
Yang Hou, Lei Liu, Tianyi Zhao, Yongfei Guo, Jiangang Shi   +4 more
doaj   +2 more sources