Results 21 to 30 of about 6,861 (141)

SQSTM1/p62 (sequestosome 1) senses cellular ubiquitin stress through E2-mediated ubiquitination [PDF]

Autophagy, 2017
The alterations in cellular ubiquitin (Ub) homeostasis, known as Ub stress, feature and affect cellular responses in multiple conditions, yet the underlying mechanisms are incompletely understood. We recently reported that the macroautophagy/autophagy receptor SQSTM1/p62, functions as a novel Ub sensor to activate autophagy upon Ub+ stress ...
Jiao, Yang, Hong, Peng, Yumin, Xu, Xiaoduo, Xie, Ronggui, Hu   +4 more
openaire   +2 more sources

Circular RNA hsa_circ_0075323 promotes glioblastoma cells proliferation and invasion via regulation of autophagy

Cell Division, 2023
Background Protein p62 (sequestosome 1) encoded by gene SQSTM1 plays a vital role in mediating protectively selective autophagy in tumor cells under stressed conditions.
Wenrui Zhang, Zhonggang Shi, Shouren Chen, Shaoshan Shen, Songjie Tu, Jian Yang, Yongming Qiu, Yingying Lin, Xuejun Dai   +8 more
doaj   +1 more source

Immunohistochemical Expression of p62 in Feline Mammary Carcinoma and Non-Neoplastic Mammary Tissue

Animals, 2022
The p62 protein, also called sequestosome 1 (SQSTM1), is a ubiquitin-binding scaffold protein. In human oncology, although the interest in the function of this protein is recent, the knowledge is now numerous, but its role in tumorigenesis is not yet ...
Gian Enrico Magi, Francesca Mariotti, Lorenzo Pallotta, Alessandro Di Cerbo, Franco Maria Venanzi   +4 more
doaj   +1 more source

p62/SQSTM1 enhances NOD2-mediated signaling and cytokine production through stabilizing NOD2 oligomerization. [PDF]

PLoS ONE, 2013
NOD2 is a cytosolic pattern-recognition receptor that senses muramyl dipeptide of peptidoglycan that constitutes the bacterial cell wall, and plays an important role in maintaining immunological homeostasis in the intestine.
Sangwook Park, Soon-Duck Ha, Macon Coleman, Shahab Meshkibaf, Sung Ouk Kim   +4 more
doaj   +1 more source

Poly(rC) binding protein 1 benefits coxsackievirus B3 infection via suppressing the translation of p62/SQSTM1

Virus Research, 2022
Coxsackievirus B3 (CVB3) is a positive single-strand RNA virus causing myocarditis, pancreatitis and meningitis. During CVB3 infection, various host cellular components, including proteins and non-coding RNAs, interact with the virus and affect viral ...
Hong-Yan He, Zhi You, Ting Ouyang, Guangze Zhao, Li-Jun Chen, Qiong Wang, Jin-Yan Li, Xin Ye, Mary H. Zhang, Decheng Yang, Xing-Yi Ge, Ye Qiu   +11 more
doaj   +1 more source

SQSTM1/p62 interacts with FKBP38 and regulates cell cycle in Cashmere goat foetal fibroblasts

Journal of Applied Animal Research, 2018
SQSTM1 (sequestosome 1, also known as p62) is a multifunctional scaffold protein implicated in diverse cell physiology processes, such as autophagy, cell signalling, and protein turnover.
Qiburi He, Yanfeng Wang, Keyu Zhao, Uyanga Binderiya, Lili Bao, Pingping Zhao, Dandan Yan, Huifang Hao, Xudong Guo, Zhigang Wang   +9 more
doaj   +1 more source

The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection

Frontiers in Cellular and Infection Microbiology, 2023
As a highly conserved, multifunctional protein with multiple domains, p62/SQSTM1 plays a crucial role in several essential cellular activities, particularly selective autophagy.
Yuhao Zhou, Yuhao Zhou, Shucheng Hua, Shucheng Hua, Lei Song, Lei Song   +5 more
doaj   +1 more source

p62/SQSTM1-induced caspase-8 aggresomes are essential for ionizing radiation-mediated apoptosis

Cell Death and Disease, 2021
The autophagy–lysosome pathway and apoptosis constitute vital determinants of cell fate and engage in a complex interplay in both physiological and pathological conditions.
Su Hyun Lee, Won Jin Cho, Abdo J. Najy, Allen-Dexter Saliganan, Tri Pham, Joseph Rakowski, Brian Loughery, Chang Hoon Ji, Wael Sakr, Seongho Kim, Ikuko Kato, Weon Kuu Chung, Harold E. Kim, Yong Tae Kwon, Hyeong-Reh C. Kim   +14 more
doaj   +1 more source

BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62

Frontiers in Cell and Developmental Biology, 2020
Molecular chaperones are critical to maintaining intracellular proteostasis and have been shown to have a protective role against alpha-synuclein-mediated toxicity.
Erik L. Friesen, Erik L. Friesen, Yu Tong Zhang, Yu Tong Zhang, Rebecca Earnshaw, Rebecca Earnshaw, Mitch L. De Snoo, Mitch L. De Snoo, Darren M. O’Hara, Darren M. O’Hara, Victoria Agapova, Hien Chau, Sophie Ngana, Sophie Ngana, Kevin S. Chen, Kevin S. Chen, Lorraine V. Kalia, Lorraine V. Kalia, Lorraine V. Kalia, Suneil K. Kalia, Suneil K. Kalia, Suneil K. Kalia   +21 more
doaj   +1 more source

Generation and characterization of human-derived induced pluripotent stem cell line (IGIBi010-A) from a patient with neurodegenerative disease phenotype carrying mutation in SQSTM1/p62 gene

Stem Cell Research
SQSTM1 (Sequestosome 1) also known as p62, plays several important physiological roles in the cell. It regulates autophagy and mitochondrial homeostasis and can further lead to metabolic reprogramming.
Istaq Ahmad, Himanshi Kapoor, Achal Kumar Srivastava, Mohammed Faruq   +3 more
doaj   +1 more source