Results 51 to 60 of about 6,861 (141)

MELK Promotes Melanoma Growth by Stimulating the NF-κB Pathway

Cell Reports, 2017
Summary: Melanoma accounts for more than 80% of skin cancer-related deaths, and current therapies provide only short-term benefit to patients. Here, we show in melanoma cells that maternal embryonic leucine zipper kinase (MELK) is transcriptionally ...
Radoslav Janostiak, Navin Rauniyar, TuKiet T. Lam, Jianhong Ou, Lihua J. Zhu, Michael R. Green, Narendra Wajapeyee   +6 more
doaj   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, Volume 13, Issue 30, 28 May 2026.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

Hepatotoxicity of Nonesterified Fatty Acids to Dairy Cows: Pathophysiological Mechanisms and Prospective Solutions

Animal Research and One Health, Volume 4, Issue 2, Page 167-184, May 2026.
Unregulated inflammation increases non‐esterified fatty acids (NEFAs), and triggers multi‐pathway hepatocyte damage including oxidative stress, mitochondrial dysfunction, and metabolic disorders in dairy cows. ABSTRACT Circulating concentrations of nonesterified fatty acids (NEFAs) are elevated due to lipid mobilization from adipose tissue in ...
Siqing Mao, Yuan Tian, Dan Li, Lei Tian, Hang Yu, Ziling Liu, Xin Gao, Yanqiong Wen, Fachun Wan, Zuo Wang, Weijun Shen, Xinwei Li, Lei Liu   +12 more
wiley   +1 more source

VGLL3 Regulates DAPK2‐Mediated Autophagy During Osteoblast Differentiation

BioFactors, Volume 52, Issue 3, May/June 2026.
VGLL3 regulates autophagic activity during osteoblast differentiation and is associated with DAPK2‐mediated autophagy. Overexpression of Dapk2 partially restores autophagy and osteogenic differentiation in Vgll3‐deficient osteoblasts. ABSTRACT Vestigial‐like family member 3 (VGLL3), a transcriptional cofactor of the TEA domain family, has been ...
Yuhan He, Ziyi Wang, Yao Weng, Heriati Sitosari, Yilin Zheng, Yaxin Qu, Mika Ikegame, Hirohiko Okamura   +7 more
wiley   +1 more source

Proteomic Analysis of Corpora Amylacea Extracted From Post‐mortem Brain of MAiD‐end‐of‐life Sporadic ALS Patients

Brain and Behavior, Volume 16, Issue 5, May 2026.
Corpora amylacea extracted from the brain of ALS patients carry a specific proteomic signature. Created in BioRender. Paquet, A. (2025) https://BioRender.com/x6dh8e0 ABSTRACT Purpose Corpora amylacea (CA) are starch‐like inclusions that accumulate in the central nervous system (CNS) with aging and are enriched in neurodegenerative conditions, including
Alexandre Paquet, Lydia Touzel‐Deschênes, Vincent Roy, Stephan Saikali, Nicolas Dupré, François Gros‐Louis   +5 more
wiley   +1 more source

NRF2 negatively regulates primary ciliogenesis and hedgehog signaling.

PLoS Biology, 2020
Primary cilia are lost during cancer development, but the mechanism regulating cilia degeneration is not determined. While transcription factor nuclear factor-erythroid 2-like 2 (NRF2) protects cells from oxidative, proteotoxic, and metabolic stress in ...
Pengfei Liu, Matthew Dodson, Deyu Fang, Eli Chapman, Donna D Zhang   +4 more
doaj   +1 more source

HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection

Frontiers in Microbiology, 2020
Autophagic cargoes ensure selective autophagy for the recognition and removal of various cytosolic aggregated proteins, damaged organelles, or pathogens. Stress granules (SGs), as antiviral immune complexes, serve a positive role in the type I interferon
Yingcheng Zheng, Yingcheng Zheng, Guoguo Zhu, Yinglian Tang, Yinglian Tang, Jun Yan, Jun Yan, Song Han, Jun Yin, Biwen Peng, Xiaohua He, Wanhong Liu, Wanhong Liu   +12 more
doaj   +1 more source

Stanniocalcin 2‐Induced Autophagy Confers Resistance of Lung Cancer Cells to EGFR Inhibition via the ERK/Beclin 1 Signaling

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Although epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) are effective in treating NSCLC with EGFR mutations, the development of resistance limits their long‐term efficacy. Autophagy has been implicated as a potential mechanism behind this acquired resistance.
Yi‐Nan Liu, Yi‐Ling Chen, Meng‐Feng Tsai, Shang‐Gin Wu, Tzu‐Hua Chang, Tzu‐Hsiu Tsai, Jin‐Yuan Shih   +6 more
wiley   +1 more source

The Roles of Alix and VPS4A in Autophagy and Endosomal Pathways and Their Relation to HBV Replication

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Alix and VPS4A function in HBV biogenesis and degradation in the context of the endosomal and autophagic pathways. Alix and VPS4A orchestrate HBV secretion and degradation via endosomal and autophagic pathways. Under normal conditions, ESCRT ensures efficient virion budding and MVB formation.
Jia Li, Thekla Kemper, Shuping Tong, Xueyue Wang, Yong Lin, Mengji Lu   +5 more
wiley   +1 more source

circRNA_SLC8A1 promotes the survival of mycobacterium tuberculosis in macrophages by upregulating expression of autophagy-related protein SQSTM1/p62 to activate the NF-κB pathway

Scientific Reports
Macrophages act as the first immune defense line of the host against Mycobacterium tuberculosis (Mtb). A previous study showed that circRNA_SLC8A1 was significantly upregulated in Mtb-infected macrophages, but its regulatory mechanism in anti ...
Zhenyun Li, Yuan Gao, Bianfang Zhang, Wei Dong, Yuling Xi, Yan Li, Junwei Cui   +6 more
doaj   +1 more source