Results 61 to 70 of about 6,861 (141)

HEATR1 deficiency promotes pancreatic cancer proliferation and gemcitabine resistance by up-regulating Nrf2 signaling

Redox Biology, 2020
The human HEAT repeat-containing protein 1 (HEATR1), consisting of 2144 amino acids, is a member of the UTP10 family and contains one HEAT repeat at its C-terminal.
Yunjiang Zhou, Keke Wang, Yang Zhou, Tao Li, Mengdi Yang, Rui Wang, Yaxin Chen, Mengran Cao, Rong Hu   +8 more
doaj   +1 more source

ERAD Component MoHrd3 Facilitates Pathogenicity and Establishes a Direct Regulation on Autophagy in Magnaporthe Oryzae

Advanced Science, Volume 13, Issue 24, 27 April 2026.
MoHrd3 plays a crucial role in regulating the pathogenicity of Magnaporthe oryzae. As an ER‐associated degradation component, MoHrd3 involves in ER stress‐triggered autophagy. It facilitates the fusion between the autophagosome and the vacuole via enhancing the interaction between MoAtg8 and MoYpt7.
Huiqing Xia, Yunna Zheng, Nan Yang, Jing Chen, Xi Wu, Ximing Zheng, Danrui Cui, Ruijin Wang, Xunli Lu, Dongli Wang, You‐liang Peng, Qian Chen   +11 more
wiley   +1 more source

Autophagy precedes apoptosis during degeneration of the Kölliker’s organ in the development of rat cochlea

European Journal of Histochemistry, 2019
The Kölliker’s organ is a transient epithelial structure during cochlea development that gradually degenerates and disappears at postnatal 12-14 days (P12-14). While apoptosis has been shown to play an essential role in the degeneration of the Kölliker’s
Shule Hou, Jiarui Chen, Jun Yang
doaj   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, Volume 293, Issue 8, Page 2314-2340, April 2026.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Targeted delivery of glucocerebrosidase to lysosomes: The LYSOTAC (LYSOsome-TArgeting Chimera) technology

Asian Journal of Pharmaceutical Sciences
Lysosomal storage diseases (LSDs) are a group of inherited metabolic disorders caused by misfolding of lysosomal proteins and their degradation via endoplasmic reticulum-associated degradation (ERAD).
Hee-Yeon Kim, Eun Nam Choi, Gee Eun Lee, Sanghwa Yoon, Su Ran Mun, Eui Jung Jung, Minji Kim, Hyomin Lim, Yang Jae Kang, Woo-Jae Park, Yong Tae Kwon, Joo-Won Park   +11 more
doaj   +1 more source

Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival

Redox Biology, 2018
Non-exudative age-related macular degeneration (AMD) is mainly caused by the accumulation of lipofuscin and drusen on the retinal pigment epithelium (RPE).
Yuichi Saito, Yoshiki Kuse, Yuki Inoue, Shinsuke Nakamura, Hideaki Hara, Masamitsu Shimazawa   +5 more
doaj   +1 more source

Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice

Frontiers in Neuroscience, 2017
Neuronal degeneration following traumatic brain injury (TBI) leads to intracellular accumulation of dysfunctional proteins and organelles. Autophagy may serve to facilitate degradation to overcome protein debris load and therefore be an important pro ...
Anne Sebastiani, Christina Gölz, Philipp G. Sebastiani, Wiesia Bobkiewicz, Christian Behl, Thomas Mittmann, Serge C. Thal, Kristin Engelhard   +7 more
doaj   +1 more source

Ally or traitor: the dual role of p62 in caspase-2 regulation

Cell Death and Disease
Caspase-2 is a unique and conserved cysteine protease that is involved in several cellular processes, including different forms of cell death, maintenance of genomic stability, and the response to reactive oxygen species.
Pavel I. Volik, Alexey V. Zamaraev, Aleksandra Y. Egorshina, Nikolay V. Pervushin, Anastasia A. Kapusta, Pyotr A. Tyurin-Kuzmin, Anastasia V. Lipatova, Thilo Kaehne, Inna N. Lavrik, Boris Zhivotovsky, Gelina S. Kopeina   +10 more
doaj   +1 more source

NSUN2-Mediated M5c Dysregulation Promotes OSCC Ferroptosis

International Dental Journal
Aim or purpose: This study aimed to investigate the role of NSUN2-mediated 5-methylcytosine (m5C) methylation in regulating ferroptosis resistance and tumor progression in oral squamous cell carcinoma (OSCC), identifying potential epitranscriptomic ...
Yunyang Lu, Wei Zhao, Fangyang Shi, Jie Wu, Hui Gao, Hui Zhang, Jiajun Hu, Shiyu Lv, Weidong Du, Runze Li   +9 more
doaj   +1 more source

Comprehensive pan-cancer analysis of p62 reveals its contribution to shaping tumor microenvironment and anti-tumor immunity

Discover Oncology
Sequestosome 1 (p62/SQSTM1) is a multifunctional adaptor protein whose dysregulation promotes tumorigenesis through autophagy, metabolic reprogramming, and immune modulation.
Zahra Nayeri, Elahe Tavakol, Marveh Rahmati, Marco Cordani, Mojgan Djavaheri-Mergny, Vahid Shariati, Mohammad Amin Moosavi   +6 more
doaj   +1 more source