Results 41 to 50 of about 100,348 (235)

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

FEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page, Rachel J. Hunt, Lauren J. Albee, Daniel Berwick, Alison Snape   +4 more
wiley   +1 more source

DTX-P7, a peptide–drug conjugate, is highly effective for non-small cell lung cancer

Journal of Hematology & Oncology, 2022
Despite tremendous success of molecular targeted therapy together with immunotherapy, only a small subset of patients can benefit from them. Chemotherapy remains the mainstay treatment for most of tumors including non-small cell lung cancer (NSCLC ...
Yao Jiang, Wei Huang, Xiaojiao Sun, Xiaozhou Yang, Youming Wu, Jiaojiao Shi, Ji Zheng, Shujie Fan, Junya Liu, Jun Wang, Zhen Liang, Nan Yang, Zhenming Liu, Yanyong Liu   +13 more
doaj   +1 more source

Identification of a novel class of cyclic penta-peptides against hepatitis C virus as p7 channel blockers

Computational and Structural Biotechnology Journal, 2022
The hepatitis C virus (HCV) p7 viroporin protein is essential for viral assembly and release, suggesting its unrealised potential as a target for HCV interventions. Several classes of small molecules that can inhibit p7 through allosteric mechanisms have
Shukun Wei, Chaolun Liu, Lingyu Du, Bin Wu, Jin Zhong, Yimin Tong, Shuqing Wang, Bo OuYang   +7 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production.

PLoS Pathogens, 2010
The hepatitis C virus (HCV) p7 protein is critical for virus production and an attractive antiviral target. p7 is an ion channel when reconstituted in artificial lipid bilayers, but channel function has not been demonstrated in vivo and it is unknown ...
Ann L Wozniak, Stephen Griffin, David Rowlands, Mark Harris, MinKyung Yi, Stanley M Lemon, Steven A Weinman   +6 more
doaj   +1 more source

Phylogenetic Analysis and Secondary and Tertiary (3D) Structure Prediction of the p7 Protein of Hepatitis C Virus [PDF]

Journal of Agricultural Chemistry and Biotechnology, 2017
 The p7 protein of Hepatitis C virus (HCV) is a small integral membrane protein consists of 63 amino acids that is crucial for assembly and release of infectious virions.
M. El Hefnawi, H. Zaghloul, E. Soweha, A. El-Morsi, Iman Mohamed   +4 more
doaj   +1 more source

Ectopic expression of RBSDV P7-1 causes male sterility in Arabidopsis.

, 2013
(A) Phenotypes of P7-1 transgenic plants (P7-1-OE) and wild-type (WT) Arabidopsis during vegetative growth. (B) Phenotypes of P7-1 transgenic lines (P7-1-OE) and wild-type (WT) Arabidopsis during reproductive development.
Qiufang Xu (485524), Feng Sun (72641), Yongjian Fan (485525), Yijun Zhou (168788), Tong Zhou (3770), Xia Yuan (485523)   +5 more
core   +1 more source

Influence of Fe Particle Size Distribution on Chemical Homogeneity, Microstructure, and Crack Formation in Fe–SiC Powder Blends Processed by PBF‐LB/M

Advanced Engineering Materials, EarlyView.
The influence of Fe particle size on in situ alloying of Fe–SiC powder blends in PBF‐LB/M is revealed. Contrary to expectations, the coarser Fe fraction provides a broader crack‐free processing window and slightly improved elemental homogeneity while producing higher but more variable hardness. The results highlight a complex trade‐off between particle
Anna Luise Strauch, Anastasiya Toenjes, Matthias Steinbacher   +2 more
wiley   +1 more source

The function of the hepatitis C virus p7 protein [PDF]

, 2010
The Hepatitis C Virus is the most common cause of chronic liver disease. Current therapy is only partially effective and fraught with side effects. A greater understanding of viral replication and new virus particle formation is thus important for ...
Ann L Wozniak
core   +1 more source