Comparative study of adenosine 3′‐pyrophosphokinase domains of MuF polymorphic toxins [PDF]
FEBS Open BioPolymorphic toxins (PT) are multidomain proteins used for interbacterial competition and pathogenesis. The N‐terminal domain of PT specifies the mode of transport and names the family, while the variable C‐terminal domain carries the toxic activity ...
Eloïse M. Paulet +6 more
doaj +4 more sources
Journal of Molecular Biology, 2023 Polymorphic toxins (PTs) are a broad family of toxins involved in interbacterial competition and pathogenesis. PTs are modular proteins that are comprised of a conserved N-terminal domain responsible for its transport, and a variable C-terminal domain bearing toxic activity.
Eric Cascales
exaly +4 more sources
A widespread toxin−antitoxin system exploiting growth control via alarmone signaling [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Under stressful conditions, bacterial RelA-SpoT Homolog (RSH) enzymes synthesize the alarmone (p)ppGpp, a nucleotide second messenger. (p)ppGpp rewires bacterial transcription and metabolism to cope with stress, and, at high concentrations, inhibits the ...
Steffi Jimmy +2 more
exaly +3 more sources
An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp
FASEB Journal, 2020 Bacteria have evolved sophisticated mechanisms to inhibit the growth of competitors. One such mechanism involves type VI secretion systems, which can be used by bacteria to directly inject antibacterial toxins into neighbouring cells.
Shehryar Ahmad, Boyuan Wang
exaly +2 more sources
Editorial: (p)ppGpp and Its Homologs: Enzymatic and Mechanistic Diversity Among the Microbes [PDF]
Frontiers in Microbiology, 2021 Katarzyna Potrykus +2 more
doaj +2 more sources
Photoaffinity Capture Compounds to Profile the Magic Spot Nucleotide Interactomes. [PDF]
Angew Chem Int Ed Engl, 2022 Molecular fishing: A family of trifunctional photoaffinity capture compounds enables the identification of putative Magic Spot Nucleotide receptors by a chemoproteomics approach. The resulting datasets cover several bacterial species, correlate with distinct nucleotide phosphorylation patterns and represent high‐value starting points for future ...
Haas TM +12 more
europepmc +3 more sources
New perspectives on the molecular mechanisms of stress signalling by the nucleotide guanosine tetraphosphate (ppGpp), an emerging regulator of photosynthesis in plants and algae. [PDF]
New Phytol, 2023 Summary The nucleotides guanosine tetraphosphate and guanosine pentaphosphate (together (p)ppGpp) are found in a wide range of prokaryotic and eukaryotic organisms where they are associated with stress signalling. In this review, we will discuss recent research highlighting the role of (p)ppGpp signalling as a conserved regulator of photosynthetic ...
Mehrez M, Romand S, Field B.
europepmc +2 more sources
Regulatory Themes and Variations by the Stress-Signaling Nucleotide Alarmones (p)ppGpp in Bacteria [PDF]
Annual Review of Genetics, 2021 Brent W Anderson +2 more
exaly +2 more sources
Biochemical and X‐ray analyses of the players involved in the faRel2/aTfaRel2 toxin–antitoxin operon
Acta Crystallographica Section F, Volume 79, Issue 10, Page 247-256, October 2023., 2023 Crystallization strategies for and structural analyses of all of the players in the faRel2/aTfaRel2 toxin–antitoxin system are reported.The aTfaRel2/faRel2 operon from Coprobacillus sp. D7 encodes a bicistronic type II toxin–antitoxin (TA) module. The FaRel2 toxin is a toxic small alarmone synthetase (toxSAS) that inhibits translation through the ...
Lucia Dominguez-Molina +6 more
wiley +1 more source
Type VI secretion system effector proteins: Effective weapons for bacterial competitiveness
Cellular Microbiology, Volume 22, Issue 9, September 2020., 2020 Abstract The Type VI secretion system (T6SS) is a protein translocation nanomachine widespread among Gram‐negative bacteria and used as a means to deliver effectors directly into target bacterial or eukaryotic cells. These effectors have a wide variety of functions within target cells that ultimately help the secreting cell gain a competitive fitness ...
Ruth E. Hernandez +2 more
wiley +1 more source