Bacteria export alarmone synthetases that produce (p)ppApp and (p)ppGpp [PDF]
mBioGuanosine penta- and tetraphosphate [(p)ppGpp] and their adenosine analogs [(p)ppApp] are bacterial second messengers known as alarmones. Members of the RelA-SpoT homolog (RSH) family synthesize (p)ppGpp to mediate the stringent response during nutrient ...
Shehryar Ahmad +10 more
doaj +4 more sources
(p)ppGpp is required for virulence of Shigella flexneri. [PDF]
Infect Immun, 2023 Infection by the enteric pathogen Shigella flexneri requires transit through the gastrointestinal tract and invasion of and replication within the cells of the host colonic epithelium.
Kago G +3 more
europepmc +6 more sources
Bacillus subtilis produces (p)ppGpp in response to the bacteriostatic antibiotic chloramphenicol to prevent its potential bactericidal effect [PDF]
mLife, 2022 Antibiotics combat bacteria through their bacteriostatic (by growth inhibition) or bactericidal (by killing bacteria) action. Mechanistically, it has been proposed that bactericidal antibiotics trigger cellular damage, while bacteriostatic antibiotics ...
Jin Yang +3 more
doaj +5 more sources
Analysis of (p)ppGpp metabolism and signaling using a dynamic luminescent reporter. [PDF]
PLoS GeneticsAs rapidly growing bacteria begin to exhaust nutrients, their growth rate slows, ultimately leading to the non-replicative state of quiescence. Adaptation to nutrient limitation requires widespread metabolic remodeling that is in part mediated by the ...
Molly Hydorn +4 more
doaj +3 more sources
(p)ppGpp imposes graded transcriptional changes to impair motility and promote antibiotic tolerance in biofilms [PDF]
npj Biofilms and Microbiomes(p)ppGpp is the master regulator of bacterial stress responses, orchestrating cellular physiology via the stringent response to promote survival and adaptation.
Florian Engelhardt +6 more
doaj +3 more sources
Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp. [PDF]
FEBS LettThe alarmones (p)ppGpp play a critical role in chloroplasts by acting as signalling molecules that regulate gene expression, protein synthesis and chloroplast (cp) development, particularly in response to stress and nutrient availability.
Zegarra V +7 more
europepmc +4 more sources
Recent functional insights into the magic role of (p)ppGpp in growth control [PDF]
Computational and Structural Biotechnology Journal, 2023 Rapid growth and survival are two key traits that enable bacterial cells to thrive in their natural habitat. The guanosine tetraphosphate and pentaphosphate [(p)ppGpp], also known as “magic spot”, is a key second messenger inside bacterial cells as well ...
Haoyan Mu +5 more
doaj +3 more sources
(p)ppGpp and DksA play a crucial role in reducing the efficacy of β-lactam antibiotics by modulating bacterial membrane permeability [PDF]
Microbiology SpectrumThe key signaling molecules in the bacterial stress-sensing pathway, the alarmone (p)ppGpp and the transcription factor DksA, play a crucial role in bacterial survival during nutritional deprivation and exposure to xenobiotics by modulating cellular ...
Meenal Chawla +8 more
doaj +3 more sources
Functional interplay between (p)ppGpp and RNAP in Acinetobacter baumannii. [PDF]
PLoS PathogensThe (p)ppGpp-dependent stress response is required for pathogenic bacteria to survive both outside and inside the host but the mechanisms behind this survival are mostly unknown. In this study, we characterize the (p)ppGpp metabolism in the opportunistic
Anthony Perrier +2 more
doaj +3 more sources
(p)ppGpp-mediated GTP homeostasis ensures survival and antibiotic tolerance of Staphylococcus aureus. [PDF]
Commun BiolAntibiotic tolerance in non-growing bacterial populations is of major concern regarding antibiotic treatment failures. Whether and how the messenger molecule (p)ppGpp contributes to this phenomenon is controversial. We show for Staphylococcus aureus that
Salzer A +8 more
europepmc +4 more sources