Results 101 to 110 of about 18,483,123 (229)

Cross-talk between two nucleotide-signaling pathways in Staphylococcus aureus. [PDF]

, 2014
Nucleotide-signaling pathways are found in all kingdoms of life and are utilized to coordinate a rapid response to external stimuli. The stringent response alarmones guanosine tetra- (ppGpp) and pentaphosphate (pppGpp) control a global response allowing ...
Alexandra R. Willis, An, Angelika Gründling, Bae, Bai, Bai, Battesti, Boles, Cashel, Cashel, Charpentier, Corrigan, Corrigan, Corrigan, Cosgrove, Dalebroux, Fiil, Fong, French, Gao, Gao, Geiger, Geiger, Geiger, Gentry, Glass, Griffiths, Gründling, Hanahan, Herbert, Horsburgh, Knutsson Jenvert, Lee, Lemos, Lisa Bowman, Lu, Lund, Luo, L̸eski, Maisonneuve, McDonough, Mehne, Memmi, Miller, Mwangi, Nagarajan, Nanamiya, Nelson, Nguyen, Ochi, Potrykus, Pozzi, Rallu, Rao, Rebecca M. Corrigan, Roelofs, Rudin, Römling, Smith, Song, Sureka, Thomaides, Volkhard Kaever, Webb, Witney, Witte, Woodward   +66 more
core   +1 more source

Nanomedicine Strategies Against Biofilm‐Associated Infections: Advances, Challenges, and Translational Barriers

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
Explore the key challenges and limitations in nanomedicine for biofilm treatment, from drug loading efficiency to antimicrobial resistance. ABSTRACT Antimicrobial resistance continues to rise globally, with biofilm‐associated infections intensifying the clinical burden through persistent tolerance to antibiotics and evasion of immune responses ...
Husni Farah, Munthar Kadhim‐Abosaoda, Hayjaa Mohaisen‐Mousa, S. Renuka Jyothi, Priya Priyadarshini‐Nayak, J. Bethanney Janney, Gurjant Singh, Ashish Singh‐Chauhan, Manoj Kumar‐Mishra   +8 more
wiley   +1 more source

Replication of plasmids derived from Shiga toxinconverting bacteriophages in starved Escherichia coli [PDF]

, 2011
The pathogenicity of Shiga toxin-producing Escherichia coli (STEC) depends on the expression of stx genes that are located on lambdoid prophages. Effective toxin production occurs only after prophage induction, and one may presume that replication of the
Nadratowska-Wesołowska, Beata, Nejman, Bożena, Szalewska-Pałasz, Agnieszka, Węgrzyn, Alicja, Węgrzyn, Grzegorz   +4 more
core  

Evolution of a genome-encoded bias in amino acid biosynthetic pathways is a potential indicator of amino acid dynamics in the environment. [PDF]

, 2014
Overcoming the stress of starvation is one of an organism's most challenging phenotypic responses. Those organisms that frequently survive the challenge, by virtue of their fitness, will have evolved genomes that are shaped by their specific environments.
Fasani, Rick A, Savageau, Michael A
core   +1 more source

Effect of (p)ppGpp on the Expression of the Vibrioferrin-Mediated Iron Acquisition System in Vibrio parahaemolyticus.

Biological and Pharmaceutical Bulletin
Bacteria have a stringent response system mediated by guanosine pentaphosphate and tetraphosphate ((p)ppGpp), which suppresses the expression of genes involved in cell growth and promotes the expression of genes involved in nutrient uptake and metabolism
T. Tanabe, K. Miyamoto, Kenjiro Nagaoka, H. Tsujibo, Tatsuya Funahashi   +4 more
semanticscholar   +1 more source

Understanding the development of bacterial colony: Physiology, new technology, and modeling

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Bacterial colonies, as dynamic ecosystems, display intricate behaviors and organizational structures that profoundly influence their survival and functionality. These communities engage in physiological and social interactions, resulting in remarkable spatial heterogeneity.
Jingwen Zhu, Pan Chu, Xiongfei Fu
wiley   +1 more source

ppGpp negatively impacts ribosome assembly affecting growth and antimicrobial tolerance in Gram-positive bacteria [PDF]

, 2016
The stringent response is a survival mechanism used by bacteria to deal with stress. It is coordinated by the nucleotides guanosine tetraphosphate and pentaphosphate [(p)ppGpp], which interact with target proteins to promote bacterial survival.
Bellows, L.E., Corrigan, R., Grundling, A., Wood, A.   +3 more
core   +1 more source

Engineering Bacteria as Living Therapeutics in Cancer Therapy

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai   +6 more
wiley   +1 more source

Crucial Role of ppGpp in the Resilience of Escherichia coli to Growth Disruption

mSphere, 2020
Bacteria grow in constantly changing environments that can suddenly become completely depleted of essential nutrients. The stringent response, a rewiring of the cellular metabolism mediated by the alarmone (p)ppGpp, plays a crucial role in adjusting ...
Clément Patacq, Nicolas Chaudet, Fabien Létisse   +2 more
doaj   +1 more source

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source