(p)ppGpp: Magic Modulators of Bacterial Physiology and Metabolism [PDF]
Frontiers in Microbiology, 2020 When bacteria experience growth-limiting environmental conditions, the synthesis of the hyperphosphorylated guanosine derivatives (p)ppGpp is induced by enzymes of the RelA/SpoT homology (RSH)-type protein family. High levels of (p)ppGpp induce a process
Wieland Steinchen +2 more
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Dynamic Metabolic Response to (p)ppGpp Accumulation in Pseudomonas putida [PDF]
Frontiers in Microbiology, 2022 The stringent response is a ubiquitous bacterial reaction triggered by nutrient deprivation and mediated by the intracellular concentrations of ppGpp and pppGpp.
Philippe Vogeleer, Fabien Létisse
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(p)ppGpp - an important player during heat shock response. [PDF]
Microlife, 2023 The alarmones and second messengers (p)ppGpp are important for the cellular response to amino acid starvation. Although the stringent response is present in many bacteria, the targets and functions of (p)ppGpp can differ between species, and our ...
Driller K, Cornejo FA, Turgay K.
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(p)ppGpp Metabolism and Antimicrobial Resistance in Bacterial Pathogens [PDF]
Frontiers in Microbiology, 2020 Single cell microorganisms including pathogens relentlessly face myriads of physicochemical stresses in their living environment. In order to survive and multiply under such unfavorable conditions, microbes have evolved with complex genetic networks ...
Bhabatosh Das, Rupak K. Bhadra
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How to quantify magic spots - a brief overview of (p)ppGpp detection and quantitation methods [PDF]
Frontiers in Molecular BiosciencesGuanosine tetra- and penta-phosphates, collectively known as (p)ppGpp, are well-known second messengers of cellular stress responses in bacteria and plants.
Filip Gąsior +2 more
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Gut microbes modulate (p)ppGpp during a time-restricted feeding regimen. [PDF]
mBio, 2023 Mammals exhibit daily fasting and feeding patterns that produce a fluctuating environment in the gut. By colonizing germfree mice with Bacteroides thetaiotaomicron and examining gene expression through a time-restricted feeding cycle, we demonstrate that
Ontai-Brenning A +3 more
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Tale of Twin Bifunctional Second Messenger (p)ppGpp Synthetases and Their Function in Mycobacteria. [PDF]
ACS Omega, 2023 M. tuberculosis, an etiological agent of tuberculosis, requires a long treatment regimen due to its ability to respond to stress and persist inside the host.
Sinha SK +6 more
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Integrated control of bacterial growth and stress response by (p)ppGpp in Escherichia coli: A seesaw fashion [PDF]
iScienceSummary: To thrive in nature, bacteria have to reproduce efficiently under favorable conditions and persist during stress. The global strategy that integrates the growth control and stress response remains to be explored.
Manlu Zhu, Haoyan Mu, Xiongfeng Dai
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Diversity in E. coli (p)ppGpp Levels and Its Consequences [PDF]
Frontiers in Microbiology, 2020 (p)ppGpp is at the core of global bacterial regulation as it controls growth, the most important aspect of life. It would therefore be expected that at least across a species the intrinsic (basal) levels of (p)ppGpp would be reasonably constant.
Beny Spira, Katia Ospino
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The extended (p)ppGpp family: New dimensions in Stress response [PDF]
Current Research in Microbial Sciences, 2021 Second messenger (p)ppGpp mediated stress response plays a crucial role in bacterial persistence and multiple drug resistance. In E. coli, (p)ppGpp binds to RNA polymerase and upregulates the transcription of genes essential for stress response while ...
Kirtimaan Syal +2 more
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