(p)ppGpp and Its Role in Bacterial Persistence: New Challenges. [PDF]
Antimicrob Agents Chemother, 2020 Antibiotic failure not only is due to the development of resistance by pathogens but can also often be explained by persistence and tolerance. Persistence and tolerance can be included in the “persistent phenotype,” with high relevance for clinics.
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Role of RelA-synthesized (p)ppGpp and ROS-induced mutagenesis in de novo acquisition of antibiotic resistance in E. coli [PDF]
iScienceSummary: The stringent response of bacteria to starvation and stress also fulfills a role in addressing the threat of antibiotics. Within this stringent response, (p)ppGpp, synthesized by RelA or SpoT, functions as a global alarmone.
Wenxi Qi +4 more
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Editorial: (p)ppGpp and Its Homologs: Enzymatic and Mechanistic Diversity Among the Microbes [PDF]
Frontiers in Microbiology, 2021 Katarzyna Potrykus +2 more
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Role of (p)ppGpp in Viability and Biofilm Formation of Actinobacillus pleuropneumoniae S8. [PDF]
PLoS ONE, 2015 Actinobacillus pleuropneumoniae is a Gram-negative bacterium and the cause of porcine pleuropneumonia. When the bacterium encounters nutritional starvation, the relA-dependent (p)ppGpp-mediated stringent response is activated.
Gang Li +5 more
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Role of (p)ppGpp in antibiotic resistance, tolerance, persistence and survival in Firmicutes. [PDF]
Microlife, 2023 The stringent response and its signalling nucleotides, pppGpp and ppGpp, have been the subject of intense research since the discovery of (p)ppGpp in 1969.
Salzer A, Wolz C.
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(p)ppGpp-dependent activation of gene expression during nutrient limitation. [PDF]
mBioAs rapidly growing bacteria begin to exhaust nutrients, their growth rate slows, ultimately leading to stasis or quiescence. Adaptation to nutrient limitation requires widespread metabolic remodeling that leads to lower cellular energy consumption ...
Nagarajan SN, Rosenthal A, Dworkin J.
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Transcriptomic Analysis Reveals Key Roles of (p)ppGpp and DksA in Regulating Metabolism and Chemotaxis in Yersinia enterocolitica. [PDF]
Int J Mol Sci, 2023 The stringent response is a rapid response system that is ubiquitous in bacteria, allowing them to sense changes in the external environment and undergo extensive physiological transformations. However, the regulators (p)ppGpp and DksA have extensive and
Huang C, Li W, Chen J.
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The constancy of global regulation across a species: the concentrations of ppGpp and RpoS are strain-specific in
BMC Microbiology, 2011 Background Sigma factors and the alarmone ppGpp control the allocation of RNA polymerase to promoters under stressful conditions. Both ppGpp and the sigma factor σS (RpoS) are potentially subject to variability across the species Escherichia coli.
Phan Katherine +4 more
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Dissection of amino acid acquisition pathways demonstrates that amino acid starvation of Borrelia burgdorferi results in a (p)ppGpp-independent maladaptive response. [PDF]
Commun BiolBorrelia burgdorferi, the causative agent of Lyme disease, is well known for its unique physiology and enzootic cycle. Building on previous work showing peptide transport is essential for viability, we endeavored to clearly define the impact of peptide ...
Kataria A +7 more
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Similar and Divergent Roles of Stringent Regulator (p)ppGpp and DksA on Pleiotropic Phenotype of Yersinia enterocolitica [PDF]
Microbiology Spectrum, 2022 Stringent response plays an important role in the response of Enterobacteriaceae pathogens to rapid environmental changes. It has been shown that synergistic and antagonistic actions exist between the signaling molecules (p)ppGpp and DksA in several ...
Can Huang +3 more
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