Inhibition of (p)ppGpp Synthesis and Membrane Fluidity Modulation by Diosgenin: A Strategy to Suppress <i>Staphylococcus aureus</i> Persister Cells. [PDF]
Int J Mol SciPersister cells are a subset of bacterial cells that exhibit transient antibiotic tolerance without genetic resistance, contributing to the persistence of chronic infections.
Seo Y, Kim M, Kim TJ.
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(p)ppGpp and moonlighting RNases influence the first step of lipopolysaccharide biosynthesis in Escherichia coli. [PDF]
Microlife, 2023 The outer membrane (OM) protects Gram-negative bacteria from harsh environmental conditions and provides intrinsic resistance to many antimicrobial compounds.
Brückner S +12 more
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Bacterial alarmone (p)ppGpp mediates the pathogenicity of <i>Clavibacter michiganensis</i> via a dual mechanism that affects both enzyme production and the Tat secretion system. [PDF]
mSystemsThe gram-positive bacterium Clavibacter michiganensis (Cm) causes bacterial canker of tomato. The infection process of Cm is of considerable interest, and the role of the alarmone guanosine tetraphosphate or pentaphosphate [(p)ppGpp], a global regulator,
Xu X +7 more
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A dual program for CRP-mediated regulation in bacterial alarmone (p)ppGpp. [PDF]
mBioGene expression and proper downstream cellular functions upon facing environmental shifts depend on the combined and cooperative regulation of genetic networks.
Zhao L +6 more
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Inhibition of SRP-dependent protein secretion by the bacterial alarmone (p)ppGpp. [PDF]
Nat Commun, 2022 The stringent response enables bacteria to respond to nutrient limitation and other stress conditions through production of the nucleotide-based second messengers ppGpp and pppGpp, collectively known as (p)ppGpp.
Czech L +12 more
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Survival of the Fittest: The Relationship of (p)ppGpp With Bacterial Virulence [PDF]
Frontiers in Microbiology, 2020 The signaling nucleotide (p)ppGpp has been the subject of intense research in the past two decades. Initially discovered as the effector molecule of the stringent response, a bacterial stress response that reprograms cell physiology during amino acid ...
Shivani Kundra +2 more
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Regulatory Themes and Variations by the Stress-Signaling Nucleotide Alarmones (p)ppGpp in Bacteria. [PDF]
Annu Rev Genet, 2021 Bacterial stress-signaling alarmones are important components of a protective network against diverse stresses such as nutrient starvation and antibiotic assault.
Anderson BW, Fung DK, Wang JD.
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Increased Levels of (p)ppGpp Correlate with Virulence and Biofilm Formation, but Not with Growth, in Strains of Uropathogenic Escherichia coli. [PDF]
Int J Mol Sci, 2023 Urinary tract infections are one of the most frequent bacterial diseases worldwide. UPECs are the most prominent group of bacterial strains among pathogens responsible for prompting such infections.
Karczewska M +5 more
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The regulatory effects of (p)ppGpp and indole on cAMP synthesis in Escherichia coli cells. [PDF]
Vavilovskii Zhurnal Genet SelektsiiBacterial stress adaptive response is formed due to changes in the cell gene expression profile in response to alterations in environmental conditions through the functioning of regulatory networks.
Kashevarova NM, Khaova EA, Tkachenko AG.
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Effects of (p)ppGpp on the progression of the cell cycle of Caulobacter crescentus. [PDF]
, 2014 Bacteria must control the progression of their cell cycle in response to nutrient availability. This regulation can be mediated by guanosine tetra- or pentaphosphate [(p)ppGpp], which are synthesized by enzymes of the RelA/SpoT homologue (Rsh) family ...
Collier, J., Gonzalez, D.
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