Novel (p)ppGpp Binding and Metabolizing Proteins of
mBio, 2018 The alarmone (p)ppGpp plays pivotal roles in basic bacterial stress responses by increasing tolerance of various nutritional limitations and chemical insults, including antibiotics.
Yong Zhang +3 more
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The nucleotide messenger (p)ppGpp is an anti-inducer of the purine synthesis transcription regulator PurR in Bacillus. [PDF]
Nucleic Acids Res, 2022 The nucleotide messenger (p)ppGpp allows bacteria to adapt to fluctuating environments by reprogramming the transcriptome. Despite its well-recognized role in gene regulation, (p)ppGpp is only known to directly affect transcription in Proteobacteria by ...
Anderson BW +9 more
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The (p)ppGpp synthetase Rsh promotes rifampicin tolerant persister cell formation in Brucella abortus by regulating the type II toxin-antitoxin module mbcTA [PDF]
Front MicrobiolPersister cells are transiently tolerant to antibiotics and are associated with recalcitrant chronic infections due to recolonization of host cells after antibiotic removal. Brucella spp.
Liu X +10 more
europepmc +2 more sources
Two P or Not Two P: Understanding Regulation by the Bacterial Second Messengers (p)ppGpp.
Annual Review of Microbiology, 2021 Under stressful growth conditions and nutrient starvation, bacteria adapt by synthesizing signaling molecules that profoundly reprogram cellular physiology.
G. Bange +3 more
semanticscholar +5 more sources
(p)ppGpp buffers cell division when membrane fluidity decreases in Escherichia coli. [PDF]
bioRxivMaintenance of fluidity an inherent property of biological membranes by homeoviscous adaptation is important for optimal functioning of membrane-associated processes. Homeoviscous adaptation in E.
Vani Singh, Harinarayanan Rajendran
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In Mycobacterium abscessus, the Stringent Factor Rel Regulates Metabolism but Is Not the Only (p)ppGpp Synthase. [PDF]
J Bacteriol, 2022 Hunt-Serracín AC +3 more
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Crosstalk between (p)ppGpp and other nucleotide second messengers. [PDF]
Curr Opin Microbiol, 2023 In response to environmental cues, bacteria produce intracellular nucleotide messengers to regulate a wide variety of cellular processes and physiology. Studies on individual nucleotide messengers, such as (p)ppGpp or cyclic (di)nucleotides, have established their respective regulatory themes.
Fung DK, Trinquier AE, Wang JD.
europepmc +3 more sources
Direct binding targets of the stringent response alarmone (p)ppGpp [PDF]
Molecular Microbiology, 2012 SummaryThe Escherichia coli stringent response, mediated by the alarmone ppGpp, is responsible for the reorganization of cellular transcription upon nutritional starvation and other stresses. These transcriptional changes occur mainly as a result of the direct effects of ppGpp and its partner transcription factor DksA on RNA polymerase.
Usheer Kanjee +2 more
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Biochemical studies on Francisella tularensis RelA in (p)ppGpp biosynthesis [PDF]
Bioscience Reports, 2015 The bacterial stringent response is induced by nutrient deprivation and is mediated by enzymes of the RSH (RelA/SpoT homologue; RelA, (p)ppGpp synthetase I; SpoT, (p)ppGpp synthetase II) superfamily that control concentrations of the ‘alarmones’ (p)ppGpp (guanosine penta- or tetra-phosphate).
Rachael C. Wilkinson +4 more
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(p)ppGpp: still magical? [PDF]
Annual Review of Microbiology, 2008 The fundamental details of how nutritional stress leads to elevating (p)ppGpp are questionable. By common usage, the meaning of the stringent response has evolved from the specific response to (p)ppGpp provoked by amino acid starvation to all responses caused by elevating (p)ppGpp by any means.
K. Potrykus, M. Cashel
semanticscholar +3 more sources