Results 51 to 60 of about 18,483,123 (229)

NirD curtails the stringent response by inhibiting RelA activity in Escherichia coli

eLife, 2021
Bacteria regulate their metabolism to adapt and survive adverse conditions, in particular to stressful downshifts in nutrient availability. These shifts trigger the so-called stringent response, coordinated by the signaling molecules guanosine tetra and ...
Loïc Léger, Deborah Byrne, Paul Guiraud, Elsa Germain, Etienne Maisonneuve   +4 more
doaj   +1 more source

SpoT Induces Intracellular Salmonella Virulence Programs in the Phagosome. [PDF]

, 2020
Guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp), together named (p)ppGpp, regulate diverse aspects of Salmonella pathogenesis, including synthesis of nutrients, resistance to inflammatory mediators, and expression of secretion ...
Fitzsimmons, Liam F, Jones-Carson, Jessica, Kant, Sashi, Kim, Ju-Sim, Liu, Lin, McClelland, Michael, Porwollik, Steffen, Till, James K, Vazquez-Torres, Andres   +8 more
core   +1 more source

Diversity in (p)ppGpp metabolism and effectors [PDF]

Current Opinion in Microbiology, 2015
Bacteria produce guanosine tetraphosphate and pentaphosphate, collectively named (p)ppGpp, in response to a variety of environmental stimuli. These two remarkable molecules regulate many cellular processes, including the central dogma processes and metabolism, to ensure survival and adaptation.
Kuanqing Liu, Alycia N Bittner, Jue D Wang   +2 more
openaire   +2 more sources

Synchronized switching of multiple toxin–antitoxin modules by (p)ppGpp fluctuation [PDF]

Nucleic Acids Research, 2017
Toxin-antitoxin (TA) loci are widespread in bacteria including important pathogenic species. Recent studies suggest that TA systems play a key role in persister formation. However, the persistence phenotype shows only weak dependence on the number of TA systems, i.e. they are functionally redundant.
Chengzhe Tian, Szabolcs Semsey, Namiko Mitarai   +2 more
openalex   +5 more sources

Structural Analysis of (p)ppGpp Reveals Its Versatile Binding Pattern for Diverse Types of Target Proteins

Frontiers in Microbiology, 2020
(p)ppGpp, highly phosphorylated guanosine, are global regulatory nucleotides that modulate several biochemical events in bacterial physiology ranging from core central dogma to various metabolic pathways.
Gajraj Singh Kushwaha, Gajraj Singh Kushwaha, Anupam Patra, Neel Sarovar Bhavesh   +3 more
doaj   +1 more source

Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis.

PLoS Pathogens, 2021
Bacteria inhabit diverse environmental niches and consequently must modulate their metabolism to adapt to stress. The nucleotide second messengers guanosine tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) (collectively referred to as (p ...
N Y Elizabeth Chau, Shehryar Ahmad, John C Whitney, Brian K Coombes   +3 more
doaj   +1 more source

Small Alarmone Synthetases RelP and RelQ of Staphylococcus aureus Are Involved in Biofilm Formation and Maintenance Under Cell Wall Stress Conditions

Frontiers in Microbiology, 2020
The stringent response is characterized by the synthesis of the alarmone (p)ppGpp. The phenotypic consequences resulting from (p)ppGpp accumulation vary among species, and for several pathogenic bacteria, it has been shown that the activation of the ...
Andrea Salzer, Daniela Keinhörster, Christina Kästle, Benjamin Kästle, Christiane Wolz   +4 more
doaj   +1 more source

Regulation of ytfK by cAMP-CRP Contributes to SpoT-Dependent Accumulation of (p)ppGpp in Response to Carbon Starvation YtfK Responds to Glucose Exhaustion

Frontiers in Microbiology, 2021
Guanosine penta- or tetraphosphate (known as (p)ppGpp) serves as second messenger to respond to nutrient downshift and other environmental stresses, a phenomenon called stringent response.
Laura Meyer, Elsa Germain, Etienne Maisonneuve   +2 more
doaj   +1 more source

Cross-regulation of (p)ppGpp and c-di-GMP pathways controls a cell-cycle transition [PDF]

bioRxiv
Corentin Jaboulay, Chloé Dugelay, José Maio, Katell Beillevaire, Philippe Vogeleer, Daniel Vinella, Fabien Létisse, Régis Hallez, Boyuan Wang, Laurent Terradot, Mathilde Guzzo   +10 more
openalex   +2 more sources

Two (p)ppGpp Synthetase Genes, relA and spoT, Are Involved in Regulating Cell Motility, Exopolysaccharides Production, and Biofilm Formation of Vibrio alginolyticus

Frontiers in Microbiology, 2022
The stringent response mediated by the signal molecule (p)ppGpp is involved in response to multiple environmental stresses and control of various physiological processes.
Wen-Liang Yin, Wen-Liang Yin, Wen-Liang Yin, Zhen-Yu Xie, Zhen-Yu Xie, Zhen-Yu Xie, Zhen-Yu Xie, Yan-Hua Zeng, Yan-Hua Zeng, Ju Zhang, Ju Zhang, Ju Zhang, Hao Long, Hao Long, Wei Ren, Wei Ren, Wei Ren, Wei Ren, Xiang Zhang, Xiang Zhang, Xiang Zhang, Xiang Zhang, Xiao-Ni Cai, Xiao-Ni Cai, Xiao-Ni Cai, Xiao-Ni Cai, Ai-You Huang, Ai-You Huang, Ai-You Huang, Ai-You Huang   +29 more
doaj   +1 more source