Results 71 to 80 of about 18,483,123 (229)
(p)ppGpp and the bacterial cell cycle
Journal of Biosciences, 2016 Genes of the Rel/Spo homolog (RSH) superfamily synthesize and/or hydrolyse the modified nucleotides pppGpp/ ppGpp (collectively referred to as (p)ppGpp) and are prevalent across diverse bacteria and in plant chloroplasts. Bacteria accumulate (p)ppGpp in response to nutrient deprivation (generically called the stringent response) and elicit appropriate ...
Aanisa, Nazir, Rajendran, Harinarayanan
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Nutritional Control of Elongation of DNA Replication by (p)ppGpp [PDF]
Cell, 2007 DNA replication is highly regulated in most organisms. Although much research has focused on mechanisms that regulate initiation of replication, mechanisms that regulate elongation of replication are less well understood. We characterized a mechanism that regulates replication elongation in the bacterium Bacillus subtilis.
Wang, Jue D. +2 more
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Nonhydrolysable Analogues of (p)ppGpp and (p)ppApp Alarmone Nucleotides as Novel Molecular Tools [PDF]
ACS Chemical Biology, 2021 While alarmone nucleotides guanosine-3',5'-bisdiphosphate (ppGpp) and guanosine-5'-triphosphate-3'-diphosphate (pppGpp) are archetypical bacterial second messengers, their adenosine analogues ppApp (adenosine-3',5'-bisdiphosphate) and pppApp (adenosine-5'-triphosphate-3'-diphosphate) are toxic effectors that abrogate bacterial growth. The alarmones are
Mojr, Viktor +13 more
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Broad-spectrum anti-biofilm peptide that targets a cellular stress response. [PDF]
PLoS Pathogens, 2014 Bacteria form multicellular communities known as biofilms that cause two thirds of all infections and demonstrate a 10 to 1000 fold increase in adaptive resistance to conventional antibiotics.
César de la Fuente-Núñez +4 more
doaj +1 more source
Activation of the Listeria monocytogenes Virulence Program by a Reducing Environment. [PDF]
, 2017 Upon entry into the host cell cytosol, the facultative intracellular pathogen Listeria monocytogenes coordinates the expression of numerous essential virulence factors by allosteric binding of glutathione (GSH) to the Crp-Fnr family transcriptional ...
Aaron T. Whiteley +5 more
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Basal Levels of (p)ppGpp in
mBio, 2013 The stringent response (SR), mediated by the alarmone (p)ppGpp, is a conserved bacterial adaptation system controlling broad metabolic alterations necessary for survival under adverse conditions.
Anthony O. Gaca +6 more
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mBio, 2020 The initiation of Escherichia coli chromosomal DNA replication starts with the oligomerization of the DnaA protein at repeat sequences within the origin (ori) region. The amount of ori DNA per cell directly correlates with the growth rate.
Llorenç Fernández-Coll +6 more
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The Prospects for Immigration Amendments [PDF]
, 1956 Obg proteins are a family of P-loop GTPases, conserved from bacteria to human. The Obg protein in Escherichia coli (ObgE) has been implicated in many diverse cellular functions, with proposed molecular roles in two global processes, ribosome assembly and
Cao, Wei +12 more
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EcoCyc: fusing model organism databases with systems biology. [PDF]
, 2012 EcoCyc (http://EcoCyc.org) is a model organism database built on the genome sequence of Escherichia coli K-12 MG1655. Expert manual curation of the functions of individual E.
Bonavides-Martínez, César +23 more
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Essential Roles for Mycobacterium tuberculosis Rel beyond the Production of (p)ppGpp [PDF]
, 2013 In Mycobacterium tuberculosis, the stringent response to amino acid starvation is mediated by the M. tuberculosis Rel (Rel(Mtb)) enzyme, which transfers a pyrophosphate from ATP to GDP or GTP to synthesize ppGpp and pppGpp, respectively.
Stallings, Christina L. +1 more
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