Results 81 to 90 of about 1,418,757 (266)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Automatic Optimization System of Cutting Condition forDifferent Types of Machining Processes

Al-Khawarizmi Engineering Journal, 2009
This research aims at calculating the optimum cutting condition for various types of machining methods, assisted by computers, (the computer program in this research is designed to solve linear programs; the program is written in v. basic language).
Huda Hatem, Ali H. Kadhum
doaj  

A Novel Multiple DBC-staked units Package to Parallel More Chips for SiC Power Module

CES Transactions on Electrical Machines and Systems
Silicon carbide (SiC) power modules play an essential role in the electric vehicle drive system. To improve their performance, reduce their size, and increase production efficiency, this paper proposes a multiple staked direct bonded copper (DBC) unit ...
Xiaoshuang Hui, Puqi Ning, Tao Fan, Yuhui Kang, Kai Wang, Yunhui Mei, Guangyin Lei   +6 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Integration of Hyperspectral Imaging and Chemometrics for Internal Quality Evaluation of Packaged and Non-Packaged Fresh Fruits

Agriculture
Research on packaged fruits has seen a notable upturn primarily driven by consumers’ desire for fruit safety and quality across the distribution network.
Umuhoza Aline, Dennis Semyalo, Muhammad Fahri Reza Pahlawan, Tanjima Akter, Mohammad Akbar Faqeerzada, Seo-Young Kim, Dayoung Oh, Byoung-Kwan Cho   +7 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Qualidade microbiana e aspecto visual de mandioca minimamente processada = Microbial quality and visual aspect of minimally processed cassava

Acta Scientiarum: Biological Sciences, 2007
Foi avaliada a qualidade microbiológica de mandioca minimamente processada, embalada a vácuo e refrigerada (4-7ºC), com quatro a oito dias de armazenamento.
Daniela Guerra Lund, Cristiane Brauer Zaicovski, Ligia Machado Prieto, Rita de Cássia dos Santos da Conceição, José Antonio Guimarães Aleixo, Cesar Valmor Rombaldi   +5 more
doaj  

Our Everyday Food and Consumer Behaviour

Studia Universitatis Babes-Bolyai Sociologia
This study explores the relationship between food labelling and consumer behaviour, with the primary aim of identifying the factors influencing food choices and evaluating the impact of education level and gender on the consultation of labels.
Boşteoca Patricia-Suzana, Oniţiu Atalia   +1 more
doaj   +1 more source