Results 81 to 90 of about 2,076,709 (312)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

R2WinBUGS: A Package for Running WinBUGS from R [PDF]

open access: yes
The R2WinBUGS package provides convenient functions to call WinBUGS from R. It automatically writes the data and scripts in a format readable by WinBUGS for processing in batch mode, which is possible since version 1.4.
Uwe Ligges   +2 more
core  

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Staggered diamond-hole IDTs for lateral spurious mode suppression in LiNbO3 XBAR

open access: yesEngineering Science and Technology, an International Journal
This work presents a LiNbO3 laterally excited bulk acoustic resonator (XBAR) with staggered diamond-hole interdigital transducers (IDTs) for suppressing higher-order A1-n spurious modes.
Pengyi Wang   +8 more
doaj   +1 more source

Automatic Time Series Forecasting: The forecast Package for R [PDF]

open access: yes
Automatic forecasts of large numbers of univariate time series are often needed in business and other contexts. We describe two automatic forecasting algorithms that have been implemented in the forecast package for R.
Rob J. Hyndman, Yeasmin Khandakar
core  

DAIME package for R

open access: yes, 2019
https://CRAN.R-project.org/package=DAIME This package allows to (1) model the effects of sedimentary condensation and dilution and (2) account for this effect in data derived from the rock ...
Niklas Hohmann (8191161), Niklas Hohmann
core   +2 more sources

RNA‐related functions of BRCA2 in transcription, replication, and genome stability

open access: yesFEBS Letters, EarlyView.
Beyond its role in homologous recombination, BRCA2 regulates R‐loop homeostasis, DNA–RNA hybrid resolution, RNA polymerase II dynamics, and transcriptional activation. Disruption of any of these functions can contribute to genome instability, inflammatory signaling, and tumorigenesis. BRCA2 is a central tumor suppressor protein best known for its roles
Lucia Alvaro‐Aranda   +2 more
wiley   +1 more source

Packaging of W-Band Power Amplifier Modules Using Waveguide-Microstrip Line Transition Feeds and High-Isolation Power Combiners

open access: yesIEEE Access
This paper presents a packaging technology for efficiently combining the output power of high-power W-band amplifiers. The waveguide power amplifier module with excellent isolation characteristics and low loss is realized using a waveguide-microstrip ...
Ikjong Bae   +6 more
doaj   +1 more source

Exact and Asymptotic Weighted Logrank Tests for Interval Censored Data: The interval R Package [PDF]

open access: yes
For right-censored data perhaps the most commonly used tests are weighted logrank tests, such as the logrank and Wilcoxon-type tests. In this paper we review several generalizations of those weighted logrank tests to interval-censored data and present an
Michael P. Fay, Pamela A. Shaw
core  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

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