Results 151 to 160 of about 6,359 (194)
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Facile Fluorescence‐Based Detection of PAD4‐Mediated Citrullination
ChemBioChem, 2013AbstractThe post‐translational modifications of histone proteins are highly diverse and dynamic processes. It is becoming increasingly evident that modifying histone proteins can have a direct influence on both cellular homeostasis and disease states. Protein arginine deiminase 4 (PAD4) is an enzyme that converts peptidyl‐arginine to citrulline.
Erin, Wildeman, Marcos M, Pires
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Plant defence against aphids: the PAD4 signalling nexus
Journal of Experimental Botany, 2014In Arabidopsis thaliana, PHYTOALEXIN DEFICIENT 4 (PAD4) functions as a key player in modulating defence against the phloem sap-feeding aphid Myzus persicae (Sülzer), more commonly known as the green peach aphid (GPA), an important pest of a wide variety of plants. PAD4 controls antibiosis and antixenosis against the GPA.
Louis, Joe, Shah, Jyoti
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In silico targeting PAD4 for the treatment of rheumatoid arthritis
Structural Chemistry, 2019Rheumatoid arthritis (RA) is an autoimmune disorder that causes chronic inflammation with periodic bursts of activity in multiple synovial joints which lead to irreversible damage of cartilage and bone. Although several drugs that reduce inflammation are used for the treatment of RA, they are often associated with side effects.
Mehul N. Soni +3 more
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Novel Heterocyclic PAD4 Inhibitors for Treating Diseases
ACS Medicinal Chemistry LettersProvided herein are novel heterocyclic PAD4 inhibitors, pharmaceutical compositions, use of such compounds in treating multiple diseases, and processes for preparing such compounds.
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Periodontitis and experimental arthritis in the absence of PAD4
2015Objectives: There is evidence of a bidirectional relationship between periodontal disease (PD) and rheumatoid arthritis (RA), although the mechanisms underlying this relationship remain undefined. Both PD and RA are associated with inflammation and citrullination, a post-translational modification of proteins catalysed by peptidylarginine deiminases ...
Adrados-Planell, Ana +10 more
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Novel Heterocyclic PAD4 Inhibitors for Treating Multiple Diseases
ACS Medicinal Chemistry LettersProvided herein are novel heterocyclic PAD4 inhibitors, pharmaceutical compositions, use of such compounds in treating multiple diseases, and processes for preparing such compounds.
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PAD4 inhibitor promotes DNA damage and radiosensitivity of nasopharyngeal carcinoma cells
Environmental Toxicology, 2021Changjie Huang, Heming Lu
exaly
Autocitrullination of PAD4 does not alter its enzymatic activity: In vitro and in silico studies
International Journal of Biochemistry and Cell Biology, 2021Chris Reutelingsperger +2 more
exaly