Results 161 to 170 of about 7,025 (177)

PAD4 Promotes NLRP3 Inflammasome Assembly Leading to NETosis

SSRN Electronic Journal, 2019
Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of disorders. We hypothesized that NLRP3 inflammasome may participate in NETosis. Using confocal microscopy, we observed the formation of ASC speck in stimulated neutrophils in the absence ...
Patrick Münzer, Roberto Negro, Shoichi Fukui, Lucas di Meglio, Deya Cherpokova, Nicoletta Sorvillo, Venkat Giri Magupalli, Long Chu, Clare M. Waterman, Robert D. Goldman, Karen M. Ridge, Hao Wu, Denisa D. Wagner   +12 more
openaire   +1 more source

Novel Heterocyclic PAD4 Inhibitors for Treating Multiple Diseases

ACS Medicinal Chemistry Letters
Provided herein are novel heterocyclic PAD4 inhibitors, pharmaceutical compositions, use of such compounds in treating multiple diseases, and processes for preparing such compounds.
openaire   +2 more sources

PAD4-dependent citrullination of nuclear translocation of GSK3β promotes colorectal cancer progression via the degradation of nuclear CDKN1A

Neoplasia, 2022
Siyu Xiao, Yuli Gao, Xinmin Fan
exaly  

LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway

Cell Biology and Toxicology, 2021
Hao Chen, Chaohua Zhu, Huixian Huang
exaly  

Cavity surface residues of PAD4 and SAG101 contribute to EDS1 dimer signaling specificity in plant immunity

Plant Journal, 2022
Joram A Dongus, Deepak D Bhandari, Eva Penner   +2 more
exaly  

PAD4 inhibitor promotes DNA damage and radiosensitivity of nasopharyngeal carcinoma cells

Environmental Toxicology, 2021
Changjie Huang, Heming Lu, Heming Lu
exaly  

Autocitrullination of PAD4 Inhibits Efferocytic Clearance of NETs in COPD

C65. COPD: PRE-CLINICAL MODELS AND MECHANISMS, 2022
R. Surolia, F.J. Li, K.G. Dsouza, P. Singh, C.T. Stephens, Z. Wang, H. Zeng, V. Antony   +7 more
openaire   +1 more source

Direct interaction between the Arabidopsis disease resistance signaling proteins, EDS1 and PAD4

EMBO Journal, 2001
Mari-Anne Newman, Bart J Feys
exaly  

Expression of peptidylarginine deiminase type 4 (PAD4) in various tumors

Molecular Carcinogenesis, 2006
Xiaotian Chang
exaly  

The Arabidopsis PAD4 Lipase-Like Domain Is Sufficient for Resistance to Green Peach Aphid

Molecular Plant-Microbe Interactions, 2020
Joram A Dongus, Deepak D Bhandari, Monika Patel   +2 more
exaly