Next-generation biomedical sensing through photoacoustic–electrochemical synergy [PDF]
Medical ReviewModern biomedical sensing increasingly demands technologies capable of capturing structural, functional, and molecular information simultaneously. Photoacoustic (PA) and electrochemical (EC) sensing individually address these needs but exhibit inherent ...
Chen Mingxi +4 more
doaj +2 more sources
c-Myc promotes metabolic reprogramming in pulmonary hypertension via the stimulation of glutaminolysis and the reductive tricarboxylic acid cycle [PDF]
Redox BiologyEndothelial cell (EC) dysfunction is key in initiating and progressing pulmonary hypertension (PH). EC dysfunction in PH leads to hyperproliferation and vascular remodeling of the pulmonary blood vessels.
Manivannan Yegambaram +10 more
doaj +2 more sources
Sodium-coupled neutral amino acid transporter 1 (SNAT1) modulates L-citrulline transport and nitric oxide (NO) signaling in piglet pulmonary arterial endothelial cells. [PDF]
PLoS ONE, 2014 There is evidence that impairments in nitric oxide (NO) signaling contribute to chronic hypoxia-induced pulmonary hypertension. The L-arginine-NO precursor, L-citrulline, has been shown to ameliorate pulmonary hypertension.
Anna Dikalova +5 more
doaj +5 more sources
Knockdown of eIF3a alleviates pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition via TGFβ1/SMAD pathway [PDF]
Journal of Translational MedicineObjective Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by vascular remodeling and involves Endothelial-to-Mesenchymal transition (EndMT) in pulmonary artery endothelial cells (PAECs).
Qiuhong Jiao +12 more
doaj +2 more sources
Iron Replacement Attenuates Hypoxic Pulmonary Hypertension by Remodeling Energy Metabolism via Regulating the HIF2α/Mitochondrial Complex I, III/ROS Axis [PDF]
BiomoleculesIron deficiency is highly prevalent in patients with idiopathic pulmonary hypertension; nevertheless, its role and clinical significance in hypoxic pulmonary hypertension (HPH) remain elusive.
Yumei Geng +3 more
doaj +2 more sources
The generation and evaluation of TKO/hCD55/hTM/hEPCR gene-modified pigs for clinical organ xenotransplantation [PDF]
Frontiers in ImmunologyIntroductionGenetically edited pigs, modified using CRISPR-Cas9 technology, hold promise as potential sources for xenotransplantation. However, the optimal combination of genetic modifications and their expression levels for initial clinical trials ...
Guoli Huai +12 more
doaj +2 more sources
Melatonin rescues cell respiration impaired by hypoxia/reoxygenation in aortic endothelial cells and affects the mitochondrial bioenergetics targeting the F1FO-ATPase [PDF]
Redox BiologyMelatonin is evaluated as a potential molecular therapy to counteract mitochondrial dysfunction caused by hypoxia/reoxygenation (H/R) in aortic endothelial cells (pAECs).
Cristina Algieri +10 more
doaj +2 more sources
Activin-A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type-II Receptor Expression. [PDF]
Pulm CircActivin‐A is elevated in pulmonary arterial hypertension (PAH) patients, and reportedly suppresses BMPR‐II. This suggests one mechanism of action for PAH drug, sotatercept, an activin‐ligand trap. However, we were unable to confirm that activin‐A reduces
Dunmore BJ +4 more
europepmc +3 more sources
Cells, 2021 Pulmonary arterial hypertension (PAH) is a devastating condition affecting the pulmonary microvascular wall and endothelium, resulting in their partial or total obstruction.
Birger Tielemans +6 more
doaj +1 more source
Pulmonary Circulation, 2022 Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by elevated pulmonary arterial pressure and organized thrombi within pulmonary arteries.
Takayuki Jujo Sanada +6 more
doaj +1 more source