Results 101 to 110 of about 4,514 (233)

Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension [PDF]

, 2015
Iron–sulfur (Fe‐S) clusters are essential for mitochondrial metabolism, but their regulation in pulmonary hypertension (PH) remains enigmatic. We demonstrate that alterations of the miR‐210‐ISCU1/2 axis cause Fe‐S deficiencies in vivo and promote PH.
Anderson, Daniel Griffith, Bader, Andrew, Dahlman, James E., Langer, Robert S   +3 more
core   +1 more source

High‐Dose Calcium Channel Blockade in PH: Old Lessons, New Tools

Pulmonary Circulation, Volume 15, Issue 4, October 2025.
ABSTRACT This letter to the editor revisits the origins of high‐dose calcium channel blocker use in pulmonary arterial hypertension (PAH) in light of bedside vasoreactivity testing, reaffirming its present‐day relevance for a selected subgroup. Integrating historical insights with modern tools, the authors highlight: the “responder” phenotype as an ...
Gianluca Pagnoni, Aurora Vicenzi, Francesca Coppi   +2 more
wiley   +1 more source

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension. [PDF]

, 2018
Concentric lung vascular wall thickening due to enhanced proliferation of pulmonary arterial smooth muscle cells is an important pathological cause for the elevated pulmonary vascular resistance reported in patients with pulmonary arterial hypertension ...
Ayon, Ramon J, Balistrieri, Angela, Black, Stephen M, Chen, Jiwang, Desai, Ankit A, Garcia, Joe GN, Gu, Yali, Makino, Ayako, Rischard, Franz, Song, Shanshan, Tang, Haiyang, Vanderpool, Rebecca, Vinjamuri, Sujana, Wang, Jian, Wang, Ziyi, Wu, Kang, Yuan, Jason X-J, Zhang, Qian, Zhou, Guofei   +18 more
core   +1 more source

Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension [PDF]

, 2018
BACKGROUND: Aldosterone is a mineralocorticoid hormone critically involved in arterial blood pressure regulation. Although pharmacological aldosterone antagonism reduces mortality and morbidity among patients with severe left-sided heart failure, the ...
Arnold, N., Boehm, M., Braithwaite, A., Ghofrani, H.A., Grimminger, F., Kiely, D.G., Kojonazarov, B., Lawrie, A., Lu, C., Novoyatleva, T., Pickworth, J., Schermuly, R.T., Seeger, W., Weissmann, N.   +13 more
core   +1 more source

Mitochondria Bioenergetic Functions and Cell Metabolism Are Modulated by the Bergamot Polyphenolic Fraction [PDF]

, 2022
open10noThe bergamot polyphenolic fraction (BPF) was evaluated in the F1FO-ATPase activity of swine heart mitochondria. In the presence of a concentration higher than 50 µg/mL BPF, the ATPase activity of F1FO-ATPase, dependent on the natural cofactor Mg2+

core   +1 more source

Inflammation and epithelial–mesenchymal transition in a CFTR‐depleted human bronchial epithelial cell line revealed by proteomics and human organ‐on‐a‐chip

The FEBS Journal, Volume 292, Issue 19, Page 5086-5104, October 2025.
Proteomic analysis of cystic fibrosis transmembrane conductance regulator knockout (CFTR‐KO) clones of 16HBE14o‐ cells showed altered pathways linked to inflammation, polymorphonuclear leukocyte (neutrophil) recruitment, and epithelial–mesenchymal transition.
Domenico Mattoscio, Luis A. Baeza, Haiqing Bai, Tommaso Colangelo, Simone Castagnozzi, Marta Marzotto, Maria Concetta Cufaro, Virginia Lotti, Yu‐Chieh Yuan, Matteo Mucci, Longlong Si, Mariachiara Zuccarini, Maria Tredicine, Simona D'Orazio, Damiana Pieragostino, Piero Del Boccio, Claudio Sorio, Marco Trerotola, Mario Romano, Roberto Plebani   +19 more
wiley   +1 more source

Assessment of NK cytotoxicity and interactions with porcine endothelial cells by live-cell imaging in 2D static and 3D microfluidic systems

Scientific Reports
Natural Killer (NK) cells are pivotal in immune responses to viral infections, malignancies, autoimmune diseases, and transplantation. Assessment of NK cell adhesion, migration, and cytotoxicity is fundamental for in vitro studies.
Thao Tran, Viktoriia Galdina, Oscar Urquidi, Daniela Reis Galvão, Robert Rieben, Takuji B. M. Adachi, Gisella L. Puga Yung, Jörg D. Seebach   +7 more
doaj   +1 more source

N6-methyladenosine modification of KLF2 may contribute to endothelial-to-mesenchymal transition in pulmonary hypertension

Cellular & Molecular Biology Letters
Background Pulmonary hypertension (PH) is a progressive disease characterized by pulmonary vascular remodeling. Increasing evidence indicates that endothelial-to-mesenchymal transition (EndMT) in pulmonary artery endothelial cells (PAECs) is a pivotal ...
Kang Kang, Jingjing Xiang, Xingshi Zhang, Yuting Xie, Mengting Zhou, Le Zeng, Junhao Zhuang, Jiahao Kuang, Yuanyuan Lin, Bozhe Hu, Qianmin Xiong, Qing Yin, Qiang Su, Xiaoyun Liao, Jun Wang, Yanqin Niu, Cuilian Liu, Jinglin Tian, Deming Gou   +18 more
semanticscholar   +1 more source

Revolutionizing Autoimmune Research: The Role of Caveolin‐1

Immunity, Inflammation and Disease, Volume 13, Issue 8, August 2025.
ABSTRACT Introduction Caveolins (Cav) include Cav‐1, Cav‐2, and Cav‐3, with Cav‐1 being the most studied due to its prominent role as a major component of plasma membrane caveolae. Cav‐1 is involved in a wide range of cellular functions and plays a key role in regulating signaling pathways related to immune responses and inflammation.
Yanan Gao, Liangyu Mi, Yingren Deng, Zhaojun Jia, Miaomiao Zhao, Yuting Hu, Yuli Ji, Xiaoyao He, Ke Xu   +8 more
wiley   +1 more source

A myoma uteri diagnosztikája és kezelése [PDF]

, 2016
Absztrakt A myoma a leggyakoribb nőgyógyászati jóindulatú daganat. Előfordulása rasszonként változó, általánosságban a reproduktív korú nők negyedét érinti.
Póka, Róbert, Török, Péter
core   +1 more source