Results 121 to 130 of about 4,514 (233)

Inward Rectifier K+ Currents Are Regulated by CaMKII in Endothelial Cells of Primarily Cultured Bovine Pulmonary Arteries.

PLoS ONE, 2015
Endothelium lines the interior surface of vascular walls and regulates vascular tones. The endothelial cells sense and respond to chemical and mechanical stimuli in the circulation, and couple the stimulus signals to vascular smooth muscles, in which ...
Lihui Qu, Lei Yu, Yanli Wang, Xin Jin, Qianlong Zhang, Ping Lu, Xiufeng Yu, Weiwei Zhong, Xiaodong Zheng, Ningren Cui, Chun Jiang, Daling Zhu   +11 more
doaj   +1 more source

Short-term hemodynamic effects of apelin in patients with pulmonary arterial hypertension [PDF]

, 2018
Apelin agonism causes systemic vasodilatation and increased cardiac contractility in humans, and improves pulmonary arterial hypertension (PAH) in animal models.
Alastalo, Apostolopoulou, Ashley, Barnes, Berry, Brame, Cheng, Dai, Falcao-Pires, Grimminger, Japp, Japp, Jing, Kleinz, Lee, Machado, McLaughlin, Morrell, Petkov, Salcedo, Sulica, Tatemoto, Tatemoto, Voswinckel   +23 more
core   +4 more sources

Regulation of VEGF mRNA expression in hypoxic pulmonary artery endothelial cells (PAECs) by histone deacetylases (HDACs)

The FASEB Journal, 2008
The mechanism by which HDACs regulate gene expression in hypoxia is not understood. Some evidence suggests that HDACs act directly on HIF‐1, a key transcription factor, to facilitate binding to the hypoxic response element (HRE). Other studies indicate that HDACs impact chromatin‐remodeling processes and modulate access of the HRE to transcriptional ...
Natavia S. Middleton, Mykhaylo Ruchko, Olena Gorodnya, Mark N. Gillespie   +3 more
openaire   +1 more source

Endothelium-specific SIRT7 targeting ameliorates pulmonary hypertension through Krüpple-like factor 4 deacetylation

Cardiovascular Research
Aims Pulmonary hypertension (PH) is a pulmonary vascular disease characterized by a high mortality rate. Pulmonary arterial endothelium cells (PAECs) serve as a primary sensor of various environmental cues, such as shear stress and hypoxia, but PAEC ...
Jin Zhang, Chenzhong Xu, Xiaolong Tang, Shimin Sun, Siqi Liu, Langmei Yang, Yuqin Chen, Qifeng Yang, Tong-You Wade Wei, Xiaojing Wu, Jian Wang, Chen Wang, Xiaosong Yan, Lei Yang, Yanqin Niu, Deming Gou, J. Shyy, Baohua Liu   +17 more
semanticscholar   +1 more source

Physiological shear stress suppresses apoptosis in human pulmonary microvascular endothelial cells

Physiological Reports, Volume 13, Issue 6, March 2025.
Abstract Physiological shear stress contributes to maintaining endothelial cell homeostasis, including suppression of apoptosis. In the pulmonary circulation, diseases such as pulmonary embolism and pulmonary hypertension result in alterations in shear stress. Shear stress has been reported to suppress endothelial apoptosis through phosphatidylinositol
Simin Yan, Nicolas M. Philip, Samuel T. Murray, Xin Yun, Michael P. Croglio, Karthik Suresh, Mahendra Damarla, Larissa A. Shimoda, Todd M. Kolb   +8 more
wiley   +1 more source

Sex-dependent influence of endogenous estrogen in pulmonary hypertension [PDF]

, 2014
Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models ...
Audrey F. Wright, David J. Rowlands, Dukes M, Girerd B, Josephine Fullerton, Kirsty M. Mair, Lynn Loughlin, Margaret Nilsen, Margaret R. MacLean, Martin J. Hussey, Matthew Thomas, Muxfeldt ES, Nicholas Duggan, Popovic RM, Silber DH, Sonia Roberts, Takahashi H, Teichmann J   +17 more
core   +1 more source

Vascular endothelial cell injury: causes, molecular mechanisms, and treatments

MedComm, Volume 6, Issue 2, February 2025.
Endothelial cell injury is considered a critical initiating factor in the pathogenesis of various diseases, triggered by multiple factors such as disturbed shear stress and mechanical injury, environmental toxins, metabolic disorders, bacterial/viral infections, and dyslipidemia.
Tian Xia, Jiachi Yu, Meng Du, Ximeng Chen, Chengbin Wang, Ruibing Li   +5 more
wiley   +1 more source

Mitochondrial Biogenesis in Hypoxic Rat Pulmonary Artery Endothelial Cells (PAECs): Possible Involvement of DNA Oxidation

The FASEB Journal, 2012
Like many stimuli promoting cell growth and proliferation, hypoxia uses reactive oxygen species (ROS) as signaling molecules. There is emerging evidence that for nuclear genes, controlled ROS‐mediated DNA damage and repair in specific promoter sequences is necessary for normal transcriptional regulation.
Mykhaylo V. Ruchko, Olena M. Gorodnya, Viktor M. Pastukh   +2 more
openaire   +1 more source

Single cell cloning generates lung endothelial colonies with conserved growth, angiogenic, and bioenergetic characteristics

Pulmonary Circulation, 2017
Pulmonary artery, capillary, and vein endothelial cells possess distinctive structures and functions, which represent a form of vascular segment specific macroheterogeneity.
Ji Young Lee, Sarah A. McMurtry, Troy Stevens   +2 more
doaj   +1 more source

Estrogen receptor-dependent attenuation of hypoxia-induced changes in the lung genome of pulmonary hypertension rats [PDF]

, 2017
17β-estradiol (E2) exerts complex and context-dependent effects in pulmonary hypertension. In hypoxia-induced pulmonary hypertension (HPH), E2 attenuates lung vascular remodeling through estrogen receptor (ER)-dependent effects; however, ER target genes ...
Albrecht, Marjorie E., Frump, Andrea L., Lahm, Tim, McClintick, Jeanette N.   +3 more
core   +1 more source