Results 11 to 20 of about 4,514 (233)

Identification of LDHA as a Potential Therapeutic Target for Pulmonary Hypertension Through Modulation of Endothelial-To-Mesenchymal Transition. [PDF]

J Cell Mol Med
Endothelial‐to‐mesenchymal transition (EndMT) induced by dysfunctional pulmonary artery endothelial cells (PAECs) is regarded as an initiating and pivotal factor in pulmonary hypertension (PH). This study focuses on identifying a novel therapeutic target
Yao M, Zhong K, Zheng X, Yang Z, Li C, Gu Y, Chen Z.   +6 more
europepmc   +3 more sources

Hypoxia-Induced Mitochondrial ROS and Function in Pulmonary Arterial Endothelial Cells

Cells
Pulmonary artery endothelial cells (PAECs) are a major contributor to hypoxic pulmonary hypertension (PH) due to the possible roles of reactive oxygen species (ROS).
Harrison Wang, Teng-Yao Song, Jorge Reyes-García, Yong-Xiao Wang   +3 more
doaj   +2 more sources

Roles of selenoprotein S in reactive oxygen species-dependent neutrophil extracellular trap formation induced by selenium-deficient arteritis

Redox Biology, 2021
Selenium (Se) deficiency and poor plasma Se levels can cause cardiovascular diseases by decreasing selenoprotein levels. Neutrophil extracellular traps (NETs) may be the vicious cycle center of inflammation in vasculitis. Here, we show that Se deficiency
Qianru Chi, Qing Zhang, Yiming Lu, Yiming Zhang, Shiwen Xu, Shu Li   +5 more
doaj   +2 more sources

Protective effects of the Terminalia bellirica tannin-induced Nrf2/HO-1 signaling pathway in rats with high-altitude pulmonary hypertension

BMC Complementary Medicine and Therapies, 2023
Background Oxidative stress and endothelial cell dysfunction induced by high-altitude hypoxia have important roles in the pathological process of high-altitude pulmonary hypertension (HAPH). Tannins present in Terminalia bellirica (Gaertn.) Roxb.
Salamaiti Aimaier, Yang Tao, Fang Lei, Zhang Yupeng, Shi Wenhui, Ainiwaer Aikemu, Dilinuer Maimaitiyiming   +6 more
doaj   +2 more sources

In pulmonary arterial hypertension, reduced BMPR2 promotes rndothelial-to-mesenchymal transition via HMGA1 and its target slug

Circulation, 2016
Background—We previously reported high-throughput RNA sequencing analyses that identified heightened expression of the chromatin architectural factor High Mobility Group AT-hook 1 (HMGA1) in pulmonary arterial endothelial cells (PAECs) from patients who ...
Cao, A, Diebold, I, Gu, M, Hennigs, JK, Hopper, RK, Moonen, JA, Rabinovitch, M, Rhodes, CJ, Tojais, NF, Wang, L   +9 more
core   +2 more sources

aPC Pretreatment of hEPCR-Expressing PAECs Attenuates Endothelial Cell Damage and Thrombosis [PDF]

The Journal of Heart and Lung Transplantation, 2016
C.T. Laird, B. French, D.G. Harris, X. Cheng, D. Ayares, R.N. Pierson, A. Azimzadeh   +6 more
openaire   +2 more sources

Proline and glucose metabolic reprogramming supports vascular endothelial and medial biomass in pulmonary arterial hypertension

JCI Insight, 2023
In pulmonary arterial hypertension (PAH), inflammation promotes a fibroproliferative pulmonary vasculopathy. Reductionist studies emphasizing single biochemical reactions suggest a shift toward glycolytic metabolism in PAH; however, key questions remain ...
Bradley M. Wertheim, Rui-Sheng Wang, Christelle Guillermier, Christiane V.R. Hütter, William M. Oldham, Jörg Menche, Matthew L. Steinhauser, Bradley A. Maron   +7 more
doaj   +2 more sources

Pulmonary Vascular Endothelial Dysfunction Is Induced by Nonpulsatile Pulmonary Blood Flow in an Ovine Classic Glenn Model. [PDF]

Compr Physiol
Pulmonary vascular disease in patients with single ventricular heart disease is a significant source of morbidity and mortality. Utilizing an integrated investigative platform that included a novel ovine Glenn model, we demonstrate early pulmonary vascular endothelial dysfunction with the initiation of the nonpulsatile pulmonary blood flow that ...
Hyde J, Smith MA, Swami N, Hwang JH, Chao Y, Boehme J, Raff GW, Nilsson CN, Gong W, Deutsch GH, Johnson EG, Wang T, Black SM, Datar SA, Maltepe E, Fineman JR.   +15 more
europepmc   +2 more sources

The Cavin-1/Caveolin-1 interaction attenuates BMP/Smad signaling in pulmonary hypertension by interfering with BMPR2/Caveolin-1 binding

Communications Biology
Caveolin-1 (CAV1) and Cavin-1 are components of caveolae, both of which interact with and influence the composition and stabilization of caveolae. CAV1 is associated with pulmonary arterial hypertension (PAH).
Shinya Tomita, Naohiko Nakanishi, Takehiro Ogata, Yusuke Higuchi, Akira Sakamoto, Yumika Tsuji, Takaomi Suga, Satoaki Matoba   +7 more
doaj   +2 more sources

Epigenetic reprogramming drives endothelial dysfunction via neuropilin-1 in pulmonary hypertension. [PDF]

Mol Med
Pulmonary arterial hypertension (PAH) is characterized by progressive vascular remodeling and right ventricular failure. Endothelial dysfunction plays a key role in PAH initiation and progression.
Ochoa MT, Leppert C, Ricchi B, Singh E, Rota M, Bisserier M.   +5 more
europepmc   +2 more sources