Results 201 to 210 of about 4,514 (233)

Endothelial Heterogeneity in the Response to Autophagy Drives Small Vessel Muscularization in Pulmonary Hypertension

Circulation
BACKGROUND: Endothelial cell (EC) apoptosis and proliferation of apoptosis-resistant cells is a hallmark of pulmonary hypertension (PH). Yet, why some ECs die and others proliferate and how this contributes to vascular remodeling is unclear.
Qi Zhang, N. Yaoita, A. Tabuchi, Shao-Fei Liu, Shiau-Haln Chen, Qiuhua Li, Niklas Hegemann, Caihong Li, J. Rodor, Sara Timm, H. Laban, Toren Finkel, Troy Stevens, Diego F. Alvarez, Lasti Erfinanda, Marc de Perrot, M. Kucherenko, Christoph Knosalla, Matthias Ochs, S. Dimmeler, Thomas Korff, Subodh Verma, Andrew H. Baker, W. M. Kuebler   +23 more
semanticscholar   +1 more source

SOX17 Regulates Nestin/p16INK4a Axis to Mitigate Endothelial Senescence in Pulmonary Arterial Hypertension

Research Square
Emerging evidence indicates that endothelial cell senescence plays a critical role in the pathogenesis of pulmonary arterial hypertension (PAH). However, the underlying mechanisms and signaling pathways driving pulmonary endothelial senescence in PAH ...
Wei Sun, Ting Wu, Zijing Zhou, Danli Jiang, Tong-You Wei, So Yun Han, John Shyy, Gang Li, Ruizheng Shi   +8 more
semanticscholar   +1 more source

miR-124/PTBP1/PKM axis modulates pulmonary artery endothelial metabolism in a pulmonary thromboembolism rat model

Journal of Thoracic Disease
Background Cellular metabolism is critical for endothelial cell function. Pulmonary artery endothelial cell (PAEC) dysfunction contributes to the progression from pulmonary embolism (PE) to chronic thromboembolic pulmonary hypertension (CTEPH).
Min-Xia Yang, Zhi-Zhu Wu, Da-Wen Wu, Xiu-Yu Liao, Qiuxia Wu, Nan Shao, Chao-Sheng Deng   +6 more
semanticscholar   +1 more source

A method for the simultaneous measurement of radon and thoron PAEC concentrations in air using a TLD monitor

Journal of Radiological Protection, 2020
The idea of using a device with thermo-luminescent detectors (TLD) for the simultaneous measurement of radon (Rn-222) and thoron (Rn-220) decay products' concentrations was invented and developed in the Silesian Centre for Environmental Radioactivity at the Central Mining Institute, Katowice, Poland.
Stanislaw Chalupnik, Krystian Skubacz
openaire   +2 more sources

Pressure Points: Endothelial Responses to Shear Stress and Pressure in Health and Pulmonary Arterial Hypertension

bioRxiv
Background Hemodynamic forces exert a profound influence on endothelial signaling and, when abnormal, contribute centrally to human vascular disease. Pulmonary arterial hypertension (PAH) is characterized by both hemodynamic derangement and pulmonary ...
Kellen Hirsch, C. Mandrycky, Isabella Kwan, H. Pi, W. Altemeier, Tim Lahm, P. J. Leary, Sina A. Gharib, Ying Zheng, S. G. Rayner   +9 more
semanticscholar   +1 more source

Abstract 974: Endothelial NOS (eNOS) Regulates Mitochondrial Oxidative Stress in Fetal Pulmonary Artery Endothelial Cells (PAEC)

Circulation, 2007
Background : Endothelial NOS regulates pulmonary vasodilation at birth by synthesis and release of NO. Exposure of fetal lung to O 2 results in increased oxidative phoshporylation and ATP release at birth. ATP stimulates NO release from eNOS.
Girija Konduri, Annie Eis, Ivane Bakhutashvili   +2 more
openaire   +1 more source

SOX17 Prevents Endothelial-Mesenchymal Transition of Pulmonary Arterial Endothelial Cells in Pulmonary Hypertension through Mediating TGF-β/Smad2/3 Signaling.

American Journal of Respiratory Cell and Molecular Biology
Endothelial to mesenchymal transition (EndMT) has been reported to cause pulmonary vascular remodeling of pulmonary hypertension (PH). We have demonstrated that SOX17, a member of the SRY-Box (SOX) transcription factor family, affects pulmonary artery ...
Xiaozhou Zou, Meng-nan Yuan, Wei Zhou, A. Cai, Yili Cheng, Zibo Zhan, Yiwen Zhang, Zongfu Pan, Xiaoping Hu, Su Zhang, Shuilian Zheng, Ting Liu, Ping Huang   +12 more
semanticscholar   +1 more source

Se former et transmettre les connaissances: Enseigner la PAEC

2016
Se former et transmettre les connaissances: Enseigner la ...
Le Jeanne, Lucie, Laurent, Philippe, Sarthou, Jean-Pierre   +2 more
openaire   +1 more source

Effects of 50 Hz sinusoidal magnetic fields on Hsp27, Hsp70, Hsp90 expression in porcine aortic endothelial cells (PAEC)

Bioelectromagnetics, 2006
AbstractThe aim of the present study was to investigate the influence of 50 Hz sinusoidal magnetic field on Hsp27, Hsp70, and Hsp90 expression in a model of primary culture of porcine aortic endothelial cells (PAEC). We took into consideration the Hsp profile in terms of mRNA expression, protein expression and protein localization inside the cells. The
BERNARDINI, CHIARA, ZANNONI, AUGUSTA, TURBA, MARIA ELENA, BACCI, MARIA LAURA, FORNI, MONICA, MESIRCA, PIETRO, REMONDINI, DANIEL, CASTELLANI, GASTONE, BERSANI, FERDINANDO   +8 more
openaire   +3 more sources

Single-Cell and Spatial Transcriptomics Identified Fatty Acid–Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension

bioRxiv
Pulmonary arterial hypertension (PAH) is a devastating disease characterized by obliterative vascular remodeling and persistent increase of vascular resistance, leading to right heart failure and premature death.
Bin Liu, D. Yi, Shuai Li, K. Ramirez, Xiaomei Xia, Yanhong Cao, Hanqiu Zhao, A. Tripathi, Shenfeng Qiu, Mrinalini Kala, R. Rafikov, Haiwei Gu, V. D. J. Perez, S. Lemay, Christopher C. Glembotski, K. Knox, S. Bonnet, V. V. Kalinichenko, You-Yang Zhao, Michael B Fallon, O. Boucherat, Z. Dai   +21 more
semanticscholar   +1 more source