Results 21 to 30 of about 4,514 (233)

Tissue factor regulates autophagy in pulmonary artery endothelial cells from chronic thromboembolic pulmonary hypertension rats via the p38 MAPK-FoxO1 pathway

Respiratory Research
Aims To detect the expression of autophagy components, p38 MAPK (p38) and phosphorylated forkhead box transcription factor O-1 (pFoxO1) in pulmonary vascular endothelial cells of chronic thromboembolic pulmonary hypertension (CTEPH) rats and to ...
Dawen Wu, Yi Lin, Minxia Yang, Hongli Li, Wenfeng Wang, Qiuxia Wu, Maohe Chen, Nan Shao, Chaosheng Deng   +8 more
doaj   +2 more sources

Endothelial Features Along the Pulmonary Vascular Tree in Chronic Thromboembolic Pulmonary Hypertension: Distinctive or Shared Facets? [PDF]

Pulm Circ
ABSTRACT Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of pulmonary embolism, characterized by the presence of organized fibro‐thrombotic material that partially or fully obstructs the lumen of large pulmonary arteries, microvasculopathy, and enlargement of the bronchial systemic vessels. The precise mechanisms underlying
Verhaegen J, Willems L, Wagenaar A, Spreuwers R, Dahdah N, Aversa L, Verbelen T, Delcroix M, Quarck R.   +8 more
europepmc   +2 more sources

Endometrial Changes Associated with Mifepristone: A Review. [PDF]

Int J Gen Med
Mifepristone is a well-established pharmaceutical agent in obstetrics and gynecology, which has expanded its therapeutic applications to Cushing’s syndrome, meningioma, and even mental disease.
Lin Q, Zhou Y.
europepmc   +2 more sources

Chloroquine Restores eNOS Signaling in Shunt Endothelial Cells via Inhibiting eNOS Uncoupling. [PDF]

Int J Mol Sci
Pulmonary arterial hypertension (PAH) is characterized by increased lung vascular stiffness and impaired vessel relaxation, primarily due to reduced nitric oxide (NO) production in endothelial cells. Recent studies indicate that chloroquine, an autophagy
Liang Y, Ornatowski W, Lu Q, Sun X, Yegambaram M, Feng A, Dong Y, Aggarwal S, Unwalla HJ, Fineman JR, Black SM, Wang T.   +11 more
europepmc   +2 more sources

Methamphetamine-Associated Pulmonary Arterial Hypertension: Impact, Mechanisms, and a Framework for Management. [PDF]

Pulm Circ
ABSTRACT Methamphetamine‐associated pulmonary arterial hypertension (Meth‐PAH) is an increasingly prevalent but understudied subtype of Group 1 pulmonary arterial hypertension (PAH). While most prevalent in the Western United States, its reach continues to expand with the evolving global methamphetamine epidemic.
Sood N, Weerasekare J, Zhyvylo I, Goncharova EA, De Marco T.   +4 more
europepmc   +2 more sources

Glucose and fatty acid metabolism involved in the protective effect of metformin against ulipristal-induced endometrial changes in rats

Scientific Reports, 2021
Ulipristal acetate (UPA) is effective in the treatment of uterine fibroids. However, its clinical use is hampered by the development of pathologic progesterone receptor modulator-associated endometrial changes (PAECs).
Marwa S. Hamza, Eman Ramadan, Salama A. Salama   +2 more
doaj   +1 more source

MicroRNA‐144‐3p controls the apoptosis of pulmonary artery endothelial cells in pulmonary arterial hypertension via the BMPR2/Smad4 signaling pathway

Clinical and Translational Discovery, 2022
Background This study was to determine the molecular mechanism of miR‐144‐3p in the treatment of pulmonary arterial hypertension (PAH). Methods Luciferase assays detected the binding site of miR‐144‐3p. Quantitative reverse transcription‐polymerase chain
Chao Shi, Xiaolei Liu, Jalil Ur Rahman, Ge Liu, Yiyao Jiang   +4 more
doaj   +1 more source

MicroRNA-483 amelioration of experimental pulmonary hypertension. [PDF]

, 2020
Endothelial dysfunction is critically involved in the pathogenesis of pulmonary arterial hypertension (PAH) and that exogenously administered microRNA may be of therapeutic benefit.
Bai, Liang, Chen, Shanshan, Chou, Chih-Hung, Cui, Xiaopei, Fan, Fenling, Gongol, Brendan, Gu, Mingxia, He, Ming, He, Yangyang, Huang, Hsien-Da, Jing, Zhi-Cheng, Lei, Yuyang, Li, Zhao, Malhotra, Atul, Miao, Yifei, Rabinovitch, Marlene, Shen, Yuan, Shyy, John Y-J, Wang, Xiaojian, Yan, Xiaosong, Zhang, Jiao, Zhang, Jin, Zhang, Yixin   +22 more
core   +1 more source

Endothelial Dec1-PPARγ Axis Impairs Proliferation and Apoptosis Homeostasis Under Hypoxia in Pulmonary Arterial Hypertension

Frontiers in Cell and Developmental Biology, 2021
Background: The hypoxia-induced pro-proliferative and anti-apoptotic characteristics of pulmonary arterial endothelial cells (PAECs) play critical roles in pulmonary vascular remodeling and contribute to hypoxic pulmonary arterial hypertension (PAH ...
Xiaoming Li, Xiaoming Li, Chengcheng Liu, Chengcheng Liu, Wenwen Qi, Qiu Meng, Hui Zhao, Zhenxiao Teng, Runtong Xu, Xinhao Wu, Fangyuan Zhu, Yiming Qin, Miaoqing Zhao, Fenglei Xu, Ming Xia, Ming Xia   +15 more
doaj   +1 more source

PTPN1 Deficiency Modulates BMPR2 Signaling and Induces Endothelial Dysfunction in Pulmonary Arterial Hypertension

Cells, 2023
Bone morphogenic protein receptor 2 (BMPR2) expression and signaling are impaired in pulmonary arterial hypertension (PAH). How BMPR2 signaling is decreased in PAH is poorly understood.
Md Khadem Ali, Xuefei Tian, Lan Zhao, Katharina Schimmel, Christopher J. Rhodes, Martin R. Wilkins, Mark R. Nicolls, Edda F. Spiekerkoetter   +7 more
doaj   +1 more source