Signal Transduction and Targeted Therapy, 2023 Exposure to the spike protein or receptor-binding domain (S-RBD) of SARS-CoV-2 significantly influences endothelial cells and induces pulmonary vascular endotheliopathy.
Kai Yang +14 more
semanticscholar +1 more source
Quantitative optical measurement of mitochondrial superoxide dynamics in pulmonary artery endothelial cells [PDF]
Journal of Innovative Optical Health Sciences, 2018 Reactive oxygen species (ROS) play a vital role in cell signaling and redox regulation, but when present in excess, lead to numerous pathologies.
Zahra Ghanian +4 more
doaj +1 more source
Selective enhancement of endothelial BMPR-II with BMP9 reverses pulmonary arterial hypertension. [PDF]
, 2015 Genetic evidence implicates the loss of bone morphogenetic protein type II receptor (BMPR-II) signaling in the endothelium as an initiating factor in pulmonary arterial hypertension (PAH).
AL Frump +67 more
core +2 more sources
Virulence, 2023 Haemophilus parasuis (H. parasuis) causes exudative inflammation, implying endothelial dysfunction during pathogen infection. However, so far, the molecular mechanism of endothelial dysfunction caused by H. parasuis has not been clarified.
Kexin Hua +10 more
doaj +1 more source
Stable isotope metabolomics of pulmonary artery smooth muscle and endothelial cells in pulmonary hypertension and with TGF-beta treatment. [PDF]
, 2020 Altered metabolism in pulmonary artery smooth muscle cells (PASMCs) and endothelial cells (PAECs) contributes to the pathology of pulmonary hypertension (PH), but changes in substrate uptake and how substrates are utilized have not been fully ...
D' Alessandro, Angelo +12 more
core +1 more source
Connexin 43 plays a role in pulmonary vascular reactivity in mice [PDF]
, 2018 Pulmonary arterial hypertension (PAH) is a chronic condition characterized by vascular remodeling and increased vaso-reactivity. PAH is more common in females than in males (~3:1).
Andrew Shaw +11 more
core +1 more source
NUCLEAR MEDICAL CENTRES OF PAEC
The Nucleus, 2020 Pakistan Atomic Energy Commission (PAEC) in the beginning of the 1960’s chalked out plans for the utilization of radiations and radioisotopes for health care of the population and setup two nuclear medical centres at Karachi and Lahore in 1960 and 1963, respectively.
openaire +1 more source
Endothelial cells decode VEGF-mediated Ca2+ signaling patterns to produce distinct functional responses [PDF]
, 2016 A single extracellular stimulus can promote diverse behaviors among isogenic cells by differentially regulated signaling networks. We examined Ca2+ signaling in response to VEGF (vascular endothelial growth factor), a growth factor that can stimulate ...
Chou, Wesley H. +7 more
core +1 more source
The effect of hypoxia on ER-β expression in the lung and cultured pulmonary artery endothelial cells [PDF]
, 2013 Indiana University-Purdue University Indianapolis (IUPUI)17-β estradiol (E2) exerts protective effects in hypoxia-induced pulmonary hypertension (HPH) via endothelial cell estrogen receptor (ER)-dependent mechanisms. However, the effects of hypoxia on ER
Selej, Mona M.A.
core +2 more sources
Dexfenfluramine and the oestrogen-metabolizing enzyme CYP1B1 in the development of pulmonary arterial hypertension [PDF]
, 2013 <p>Aims: Pulmonary arterial hypertension (PAH) occurs more frequently in women than men. Oestrogen and the oestrogen-metabolising enzyme cytochrome P450 1B1 (CYP1B1) play a role in the development of PAH.
Abenhaim +54 more
core +1 more source