Results 61 to 70 of about 4,514 (233)

Anti-Neu5Gc and anti-non-Neu5Gc antibodies in healthy humans. [PDF]

PLoS ONE, 2017
Our group previously investigated the levels of anti-Gal and anti-nonGal IgM and IgG in a cohort of 75 healthy humans of various backgrounds, and found some significant differences related to factors such as age, gender, ABO blood group, diet ...
Bingsi Gao, Cassandra Long, Whayoung Lee, Zhongqiang Zhang, Xiaotian Gao, Doug Landsittel, Mohamed Ezzelarab, David Ayares, Yuliang Huang, David K C Cooper, Yi Wang, Hidetaka Hara   +11 more
doaj   +1 more source

Effect of RNA interference with HIF-1α on the growth of pulmonary artery endothelial cells in broiler chickens

Poultry Science
: Pulmonary artery remodeling is a characteristic feature of broiler ascites syndrome (BAS). Pulmonary artery endothelial cells (PAECs) regulated by HIF-1α play a critical role in pulmonary artery remodeling, but the underlying mechanisms of HIF-1α in ...
Wen Peng, Weile Fang, Xiaona Gao, Xiaoquan Guo, Guyue Li, Fengping Guo, Guoliang Hu, Yu Zhuang, Lin Li, Chenxi Jiang, Ping Liu   +10 more
doaj   +1 more source

Rationale and design of ASTEROID 2, a randomized, placebo- and active comparator-controlled study to assess the efficacy and safety of vilaprisan in patients with uterine fibroids [PDF]

, 2017
Background: Uterine fibroids (UFs) may be treated with progesterone receptor modulators (PRMs), which have been shown to reduce heavy menstrual bleeding and the size of UFs.
Bumbuliene, ana, Bumbuliene, Zana, Cano Sanchez, Antonio, Costa, Ana Rosa, Gemzell-Danielsson, Kristina, Heikinheimo, Oskari, Heweker, Andrea, Hudecek, Robert, Jacquemyn, Yves, Melis, Gian Benedetto, Parashar, Pooja, Rechberger, Tomasz, Seitz, Christian, van Aken, Bart, Zatik, Janos   +14 more
core   +1 more source

SOX17 Deficiency Mediates Pulmonary Hypertension: At the Crossroads of Sex, Metabolism, and Genetics

American Journal of Respiratory and Critical Care Medicine, 2023
Rationale Genetic studies suggest that SOX17 (SRY-related HMG-box 17) deficiency increases pulmonary arterial hypertension (PAH) risk. Objectives On the basis of pathological roles of estrogen and HIF2α (hypoxia-inducible factor 2α) signaling in ...
Shreya Sangam, Xutong Sun, Tae‐Hwi Schwantes‐An, M. Yegambaram, Qing Lu, Yinan Shi, T. Cook, A. Fisher, A. Frump, A. Coleman, Yanan Sun, Shuxin Liang, Howard Crawford, K. Lutz, Avinash D Maun, M. Pauciulo, J. Karnes, K. Chaudhary, D. Stewart, P. Langlais, Mohit Jain, M. Alotaibi, T. Lahm, Yan Jin, Haiwei Gu, Haiyang Tang, W. Nichols, S. Black, Ankit A Desai   +28 more
semanticscholar   +1 more source

Endothelial downregulation of nuclear m6A reader YTHDC1 promotes pulmonary vascular remodeling in sugen hypoxia model of pulmonary hypertension

Heliyon
Background: Pulmonary hypertension (PH) is characterized with vascular remodeling, which is intiated by vascular endothelial dysfunction. N6-methyladenosine (m6A) modification mediates gene expression in many ways including mediating RNA degradation ...
Hao Zheng, Di Wu, Xiangyu Chen, Wenjuan He, Jing Hua, Qiang Li, YingQun Ji   +6 more
doaj   +1 more source

Imbalanced prostanoid release mediates cigarette smoke-induced human pulmonary artery cell proliferation

Respiratory Research, 2022
Background Pulmonary hypertension is a common and serious complication of chronic obstructive pulmonary disease (COPD). Studies suggest that cigarette smoke can initiate pulmonary vascular remodelling by stimulating cell proliferation; however, the ...
Abdullah A. Alqarni, Oliver J. Brand, Alice Pasini, Mushabbab Alahmari, Abdulrhman Alghamdi, Linhua Pang   +5 more
doaj   +1 more source

Expression of NeuGc on Pig Corneas and Its Potential Significance in Pig Corneal Xenotransplantation [PDF]

, 2016
PURPOSE: Pigs expressing neither galactose-α1,3-galactose (Gal) nor N-glycolylneuraminic acid (NeuGc) take xenotransplantation one step closer to the clinic. Our aims were (1) to document the lack of NeuGc expression on corneas and aortas and cultured
Ayares, David, Cooper, David K. C., Ekser, Burcin, Hara, Hidetaka, Lee, Whayoung, Long, Cassandra, Miyagawa, Yuko, Ramsoondar, Jagdeece, Tector, A. Joseph, Tector, Alfred, Walters, Eric   +10 more
core   +1 more source

Dynamic changes in lung microRNA profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline [PDF]

, 2010
<b>Objective</b>: MicroRNAs (miRNAs) are small noncoding RNAs that have the capacity to control protein production through binding "seed" sequences within a target mRNA. Each miRNA is capable of potentially controlling hundreds of genes.
Baker, Andrew H., Caruso, Paola, Dempsie, Yvonne, Denby, Laura, Greig, Jenny A., Khanin, Raya, Long, Lu, MacDonald, Robert A., MacLean, Margaret R., Masson, Rachel, McClure, John, Morrell, Nicholas W., Robertson, Keith E., Soon, Elaine, Southgate, Mark   +14 more
core   +1 more source

RECOLLECTIONS FROM THE EARLY DAYS OF THE PAEC

The Nucleus, 2020
A committee constituted in January 1955 to prepare R&D program for the utilization of nuclear energy, recommended the establishment of the Atomic Energy Commission, which was created on February 24th 1956. Dr. Nazir Ahmad, the first chairman, assumed the office on April 11th, 1956.
openaire   +1 more source

Differential Induction of Type I and Type III Interferons by Swine and Human Origin H1N1 Influenza A Viruses in Porcine Airway Epithelial Cells. [PDF]

PLoS ONE, 2015
Interferons (IFNs) have been shown to inhibit influenza A virus (IAV) replication and play an essential role in controlling viral infection. Here we studied the kinetics and magnitude of induction of type I and type III IFN transcripts by primary porcine
Venkatramana D Krishna, Erin Roach, Nathan A Zaidman, Angela Panoskaltsis-Mortari, Jessica H Rotschafer, Scott M O'Grady, Maxim C-J Cheeran   +6 more
doaj   +1 more source