Paeonol Ameliorates Chronic Itch and Spinal Astrocytic Activation via CXCR3 in an Experimental Dry Skin Model in Mice [PDF]
Frontiers in Pharmacology, 2022 Paeonol is a bioactive phenol presents mainly in Paeonia suffruticosa Andr. (Paeoniaceae), Paeonia lactiflora Pall., and Dioscorea japonica Thunb. (Dioscoreaceae), harboring various pharmacological activities including anti-inflammatory, antioxidant ...
Wen Wang +11 more
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Paeonol eradicates biofilm in porcine-source Escherichia coli by targeting the quorum sensing system [PDF]
BMC Veterinary ResearchBackground Natural active compounds hold significant potential to overcome biofilm-mediated resistance, offering a promising therapeutic strategy for combating bacterial biofilms resistance.
Hongzao Yang +10 more
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Antifungal activity of paeonol against Botrytis cinerea by disrupting the cell membrane and the application on cherry tomato preservation [PDF]
Frontiers in MicrobiologyBotrytis cinerea may cause gray mold in fruits and vegetables. Paeonol, an active component of traditional Chinese medicine, could suppress various microbial growth. However, reports on its effect on B. cinerea have not yet been documented. In this paper,
Yang Jiao +6 more
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Paeonol ameliorates ferroptosis and inflammation in chondrocytes through AMPK/Nrf2/GPX4 pathway [PDF]
Frontiers in PharmacologyIntroductionChondrocyte ferroptosis is an important component of the pathogenesis of osteoarthritis. Paeonol, the main pharmacologically active ingredient of the Paeonia suffruticosa Andrews, is a natural radical scavenger with potent biological ...
Shuwei Gong +6 more
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Paeonol inhibits the Glycolysis in oral squamous cell carcinoma though suppressing NAT10-mediated ac4C modification [PDF]
BMC CancerBackground Oral squamous cell carcinoma (OSCC) is the most common malignant tumor of the oral and maxillofacial regions. Paeonol, derived from Moutan Cortex, has diverse pharmacological effects including anti-inflammatory and anticancer activities. The N-
Kang Yang +5 more
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Frontiers in Cellular and Infection Microbiology, 2022 Fungal populations are commonly found in natural environments and present enormous health care challenges, due to increased resistance to antifungal agents.
Weidong Qian +5 more
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Anti-tumor effects of paeonol in melanoma by up-regulating miR-143 and suppressing its target WNT5B
STEMedicine, 2023 Previous studies have shown the potent anti-tumor effect of paeonol, a natural compound extracted from traditional Chinese herb medicine. However, the therapeutic effect and underlying mechanisms of paeonol in melanoma are largely unknown.
Meishan Piao, Guangdong Feng
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Evaluation of paeonol skin-target delivery from its microsponge formulation: in vitro skin permeation and in vivo microdialysis. [PDF]
PLoS ONE, 2013 The aim of the present study was to design a novel topical skin-target drug-delivery system, the paeonol microsponge, and to investigate its drug-release patterns in dosage form, both in vitro and in vivo.
Sha-Sha Li +9 more
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Redox Biology, 2021 Diabetes disrupts mitochondrial function and often results in diabetic cardiomyopathy (DCM). Paeonol is a bioactive compound that has been reported to have pharmacological potential for cardiac and mitochondrial protection. This study aims to explore the
Chaoyang Liu +12 more
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Antioxidants, 2022 Hepatic ischemia/reperfusion (HIR) is the most common type of liver injury following several clinical situations. Modulating oxidative stress and inflammation by Nrf2/HO-1 and TLR4/MYD88/NF-κB pathways, respectively, is involved in alleviating HIR injury.
Mohamed A. Morsy +7 more
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