Results 11 to 20 of about 3,468 (201)
Pharmacokinetics, Tissue Distribution and Excretion of Paeonol and Its Major Metabolites in Rats Provide a Further Insight Into Paeonol Effectiveness [PDF]
Frontiers in Pharmacology, 2020 Paeonol is a major bioactive ingredient in Moutan Cortex (the root barks of Paeonia suffruticosa Andrews) and exhibited a wide range of bioactivities such as anti-inflammation, anti-oxidation, hypoglycemic effect, analgesic, and others.
Xintong Hu +14 more
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Biological Activities of Paeonol in Cardiovascular Diseases: A Review [PDF]
Molecules, 2021 Paeonol is a naturally existing bioactive compound found in the root bark of Paeonia suffruticosa and it is traditionally used in Chinese medicine for the prevention and management of cardiovascular diseases.
Shalini Vellasamy +5 more
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A review on therapeutical potential of paeonol in atherosclerosis
Frontiers in Pharmacology, 2022 The morbidity and mortality of atherosclerotic cardiovascular disease (ASCVD) is increasing year by year. Cortex Moutan is a traditional Chinese medicinal herb that has been widely used for thousands of years to treat a wide variety of diseases in ...
Wei Yu +4 more
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Paeonol Inhibits Cell Growth by Inducing Ferroptosis in Human Glioma Cells. [PDF]
Pharmacol Res PerspectABSTRACT Paeonol (PAE), a phenolic phytochemical derived from traditional Chinese medicinal plants, exhibits multifaceted pharmacological properties including demonstrated antitumor efficacy against hepatic, gastric, and breast carcinomas. However, its therapeutic potential in glioma remains unexplored.
Li X +8 more
europepmc +2 more sources
Paeonol Induces Protective Autophagy in Retinal Photoreceptor Cells [PDF]
Frontiers in Pharmacology, 2021 Background: Retinal photoreceptor (RP) cells are widely involved in retina-related diseases, and oxidative stress plays a critical role in retinal secondary damage. Herein, we investigated the effectiveness and potential mechanisms of autophagy of paeonol (Pae) in terms of oxidation resistance.Methods: The animal model was induced by light damage (LD ...
Daowei Zhang +9 more
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Frontiers in Cardiovascular Medicine, 2021 With improvement in living standards and average life expectancy, atherosclerotic cardiovascular disease incidences and mortality have been increasing annually.
Min Wu +8 more
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ASN Neuro, 2021 Intracerebral haemorrhage (ICH) is a devastating subtype of stroke with high morbidity and mortality. It has been reported that paeonol (PAN) inhibits the progression of ICH. However, the mechanism by which paeonol mediates the progression of ICH remains
Zheng-Long Jin +6 more
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Alterations of medial prefrontal cortex bioelectrical activity in experimental model of isoprenaline-induced myocardial infarction [PDF]
, 2020 Background Clinical and animal studies have found that anxiety and depression are significantly more common after acute myocardial infarction (AMI).
Hrnčić, Dragan +7 more
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Pharmacokinetics of Purified Paeonol and Paeonol in Moutan Cortex Decoction and Rhubarbmoutan Decoction [PDF]
Pharmaceutica Analytica Acta, 2011 180 KM male mice of 22~28g body weight were divided into three groups randomly and purified paeonol, Moutan Cortex decoction and Rhubarbmoutan decoction were orally administered at equivalent doses of 10 mg·kg -1 paeonol. A sensitive HPLC method was established and evaluated for determining the concentrations of paeonol in mice ...
Wu Jing, Zhang Rui, Yuan Gui-yan
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Antidepressant-like Effect of Paeonol [PDF]
Pharmaceutical Biology, 2006 AbstractThe current study investigated the putative antidepressant-like effect of paeonol, a phenolic component from the root bark of Paeonia suffruticosa. Andr. (Ranunculaceae), in mice or rats using the tail suspension test (TST) and forced swimming test (FST), two widely accepted pharmacological models for detecting antidepressant activity in modern
Weili Zhu +3 more
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