Results 41 to 50 of about 3,468 (201)

Paeonol Protects against Methotrexate Hepatotoxicity by Repressing Oxidative Stress, Inflammation, and Apoptosis—The Role of Drug Efflux Transporters

Pharmaceuticals, 2022
Methotrexate (MTX) is an effective chemotherapeutic agent against a wide range of tumors and autoimmune diseases; however, hepatotoxicity limits its clinical use.
Mohamed A. Morsy, Rania Abdel-Latif, Sara Mohamed Naguib Abdel Hafez, Mahmoud Kandeel, Seham A. Abdel-Gaber   +4 more
doaj   +1 more source

Development of Paeonol Liposomes: Design, Optimization, in vitro and in vivo Evaluation

International Journal of Nanomedicine, 2022
Shan Huang,1 Bingtao Zhai,1 Yu Fan,2 Jing Sun,1 Jiangxue Cheng,1 Junbo Zou,1 Xiaofei Zhang,1 Yajun Shi,1 Dongyan Guo1 1Shaanxi Province Key Laboratory of New Drugs and Chinese Medicine Foundation Research, College of Pharmacy, Shaanxi University of ...
Huang S, Zhai B, Fan Y, Sun J, Cheng J, Zou J, Zhang X, Shi Y, Guo D   +8 more
doaj  

Paeonol-Loaded Ethosomes as Transdermal Delivery Carriers: Design, Preparation and Evaluation

Molecules, 2018
Paeonol exhibits a wide range of pharmacological activities, such as anti-inflammatory, antidiabetic as well as pain-relieving activities. However, its intrinsic properties, such as low water solubility, poor stability and low oral bioavailability ...
Hongdan Ma, Dongyan Guo, Yu Fan, Jing Wang, Jiangxue Cheng, Xiaofei Zhang   +5 more
doaj   +1 more source

Paeonol represses A549 cell glycolytic reprogramming and proliferation by decreasing m6A modification of Acyl-CoA dehydrogenase

Chinese Journal of Physiology, 2023
Aberrant glycolytic reprogramming is involved in lung cancer progression by promoting the proliferation of non-small cell lung cancer cells. Paeonol, as a traditional Chinese medicine, plays a critical role in multiple cancer cell proliferation and ...
Lixin Zhang, Lihua Wu, Xiangrui Zhu, Jian Mei, Yingli Chen   +4 more
doaj   +1 more source

Paeonol inhibits profibrotic signaling and HOTAIR expression in fibrotic buccal mucosal fibroblasts

Journal of the Formosan Medical Association, 2022
Background/purpose: Betel nut chewing is the major risk factor of oral submucous fibrosis (OSF). Various studies have sought to discover alternative strategies to alleviate oral fibrogenesis.
Dennis Chun-Yu Ho, Szu-Han Chen, Chih-Yuan Fang, Chang-Wei Hsieh, Pei-Ling Hsieh, Yi-Wen Liao, Cheng-Chia Yu, Lo-Lin Tsai   +7 more
doaj   +1 more source

Preparation and Characterization of a Complex of Paeonol and Hydroxypropyl-β-cyclodextrin [PDF]

, 2015
Purpose: To improve the solubility of paeonol in water by complexing with hydroxypropyl-β-cyclodextrin (HP-β-CD) and also to characterize the physicochemical properties of the complex.Methods: The complex of paeonol and HP-β-CD was prepared by freeze ...
Chen, C, Li, Y, Ma, H, Xu, X
core   +2 more sources

Paeonol at Certain Doses Alleviates Aggressive and Anxiety-Like Behaviours in Two Premenstrual Dysphoric Disorder Rat Models

Frontiers in Psychiatry, 2020
Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome (PMS), a common mental health disturbance associated with several periodic psychological symptoms in women.
Hao Zhang, Xiwen Geng, Xiwen Geng, Zifa Li, Zifa Li, Yaqiong Li, Kaiyong Xu, Kaiyong Xu, Hongyun Wu, Jinlu Xie, Peng Sun, Sheng Wei, Sheng Wei, Mingqi Qiao   +13 more
doaj   +1 more source

Antifungal activity and potential mechanism of paeonol against Fusarium graminearum and the application on wheat grains and steamed bread

Grain & Oil Science and Technology
Fusarium graminearum (F. graminearum) is a severe phytopathogen threatening agriculture production and food security. Paeonol, serves as a plant-derived natural component, is a promising antifungal agent.
Yiming Zhang, Hongying Xiao, Roland Ernest Poms, Qian Li, Renyong Zhao   +4 more
doaj   +1 more source

Paeonol Inhibits Oxidized Low-Density Lipoprotein-Induced Vascular Endothelial Cells Autophagy by Upregulating the Expression of miRNA-30a

Frontiers in Pharmacology, 2018
Paeonol from Cortex Moutan root is a potential therapeutic agent for atherosclerosis (AS). However, its mechanisms of action are still not fully understood.
Chao Li, Li Yang, Hongfei Wu, Hongfei Wu, Min Dai, Min Dai, Min Dai   +6 more
doaj   +1 more source

Paeonol alleviates migration and invasion of endometrial stromal cells by reducing HIF-1α-regulated autophagy in endometriosis

Frontiers in Bioscience-Landmark, 2021
Background: Dysregulated migration and invasion of endometrial stromal cells is implicated in the pathogenesis of endometriosis. Hypoxia functions as critical microenvironmental factor that results in promotion of endometrial stromal cells migration and ...
Conghui Pang, Zhijuan Wu, Xiaoyan Xu, Wenxiu Yang, Xiaoxuan Wang, Yinghua Qi   +5 more
doaj   +1 more source