Results 51 to 60 of about 3,468 (201)

Paeonol Improves Cardiac Remodelling in MI Mice by Suppressing NOX2 mRNA Expression to Mitigate Oxidative Stress and Mitochondrial Dysfunction. [PDF]

J Cell Mol Med
ABSTRACT Myocardial infarction (MI), a primary contributor to mortality from cardiovascular diseases, continues to pose a significant challenge in clinical treatment. In this study, our objective was to investigate the cardioprotective effects of paeonol (PAE) on mice with MI, and to delve into the precise mechanisms underlying these effects.
Liu Y, Wu Z, Jin X, Ji M, Huang T, Meng P, Xu T, You W, Zhao Y, Ye F, Wu X.   +10 more
europepmc   +2 more sources

Modulating Effect of Paeonol on Piglets With Ulcerative Colitis

Frontiers in Nutrition, 2022
Piglet enteritis is a major problem that needs to be solved urgently in modern pig production. Paeonol (Pae) has been used as a novel treatment option due to its good medicinal value. This study purported to elucidate the regulatory mechanism of Pae on dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) in weaned piglets.
Shanshan Wang, Miaomiao Bai, Qingyan Shu, Zhengan Liu, Yirui Shao, Kang Xu, Xia Xiong, Hongnan Liu, Yao Li   +8 more
openaire   +3 more sources

Conference Report: Sixth Annual Young Researcher Forum of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine

Traditional &Kampo Medicine, Volume 13, Issue 1, April 2026.
ABSTRACT Background Nine young researchers presented their studies in the field of traditional Japanese Kampo medicine (Wakan‐yaku) at the Sixth Annual Young Researcher Forum held the day before the 2025 annual meeting of the Japan Society of Medical and Pharmaceutical Sciences for Traditional Medicine. Main Presentations Dr.
Tetsuhiro Yoshino, Kensuke Nakajima, Kousuke Araki, Tomoki Sekiya, Sakura Takamatsu, Motoya Miyahara, Ryuya Takada, Ryohei Nishimoto, Takumi Nagamatsu, Mebuki Hama, Ximeng Yang, Kazuhito Murakami, Mayumi Kamigaki, Hirokazu Ando, Souichi Nakashima   +14 more
wiley   +1 more source

Neuroprotective Effect of Paeonol in the Rat Model of Traumatic Brain Injury

Ankara Üniversitesi Tıp Fakültesi Mecmuası, 2020
Objectives:Traumatic brain injury (TBI) is a major cause of disability and mortality that induces oxidative stress and apoptosis causing cellular damage.
Emine Arık, Habibullah Dolgun, Pınar Kuru Bektaşoğlu, Julide Ergil, Banu Coşkun Yılmaz, Çağhan Tönge, Özden Çağlar Öztürk, Levent Gürses, Bora Gürer   +8 more
doaj   +1 more source

Encapsulation of vanilin/cyclodextrin inclusion complex in electrospun polyvinyl alcohol (PVA) nanowebs: Prolonged shelf-life and high temperature stability of vanilin [PDF]

, 2012
Cataloged from PDF version of article.We produced functional nanowebs, containing vanillin, having prolonged shelf-life and high temperature stability facilitated by cyclodextrin (CD) inclusion complexation. Polyvinyl alcohol (PVA) nanowebs incorporating
Kayaci, F., Uyar, T.
core   +1 more source

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, Volume 13, Issue 18, 27 March 2026.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

Involvement of MAPKs in ICAM-1 Expression in Glomerular Endothelial Cells in Diabetic Nephropathy [PDF]

, 2011
Inflammatory processes are involved in the pathogenesis of diabetic nephropathy. The aim of this study was to clarify the role of mitogen-activated protein kinase (MAPK) pathways for induction of intercellular adhesion molecule-1 (ICAM-1) expression in ...
Kodera, Ryo, Makino, Hirofumi, Omori, Kazuyoshi, Sarai, Kei, Sato, Chikage, Shikata, Kenichi, Shikata, Yasushi, Wada, Jun, Watanabe, Naomi   +8 more
core   +1 more source

Heat Stress Modulates WDR5‐Mediated H3K4me3 Modification to Induce Melanogenesis via Activating CX3CL1/CX3CR1 Axis

Advanced Science, Volume 13, Issue 7, 3 February 2026.
This study elucidates the mechanism by which heat stress regulates skin pigmentation: heat stress upregulates CX3CL1 through the MYC‐WDR5‐H3K4me3 axis, thereby activating the CX3CL1/CX3CR1‐JNK signaling pathway and ultimately promoting melanogenesis. These findings provide novel potential therapeutic targets for pigmentary skin disorders.
Yushan Zhang, Ling Jiang, Yibo Hu, Chuhan Fu, Jinhua Huang, Jing Chen, Qinghai Zeng   +6 more
wiley   +1 more source

Kaempferol Attenuates Oxidative Stress‐Induced Injury in Gastric Mucosal Cells by Activating Nrf2/GPX4 Axis to Inhibit Ferroptosis

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Objective This study explores how Kaempferol (KAE) protects against oxidative stress‐induced damage by suppressing ferroptosis via the Nrf2/GPX4 axis in gastric mucosal cells. Methods Human gastric epithelial cells (GES‐1) were treated with H₂O₂ to induce oxidative damage, following pretreatment with varying doses of KAE.
Chao Luo, Jing Yan, Yun Shen, Zhiguang Sun, Xiong Xiao   +4 more
wiley   +1 more source

Paeonol administration alleviates cognitive deficits and attenuates neural pathological changes in APP/PS1 mice

Journal of Integrative Neuroscience, 2021
Alzheimer’s disease typically presents with impaired cognition and pathological morphologic changes, including the accumulation of amyloid-β plaques. Disease-modifying drugs are in urgent need as neuroprotective therapies.
Shengxi Meng, Bing Wang, Wentao Li   +2 more
doaj   +1 more source