Results 61 to 70 of about 3,468 (201)

AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia [PDF]

, 2017
Thymoquinone is a known inhibitor of neuroinflammation. However, the mechanism(s) involved in its action remain largely unknown. In this study, we investigated the roles of cellular reactive oxygen species (ROS), 5′ AMP-activated protein kinase (AMPK ...
El-Bakoush, Abdelmeneim, Lepiarz, Izabela, Ogunrinade, Folashade, Olajide, Olumayokun A, Velagapudi, Ravikanth   +4 more
core   +1 more source

Paeonol attenuates inflammation-mediated neurotoxicity and microglial activation

Neural Regeneration Research, 2013
Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. The root of Paeonia lactiflora Pall has been considered useful for the treatment of various disorders in traditional oriental medicine.
Nam, Kyong Nyon, Woo, Byung-Cheol, Moon, Sang-Kwan, Park, Seong-Uk, Park, Joo-young, Hwang, Jae-Woong, Bae, Hyung-Sup, Ko, Chang-Nam, Lee, Eunjoo Hwang   +8 more
openaire   +2 more sources

Eutectic-based liposome as a potential delivery system of paeonol

RSC Advances, 2021
A THEDES based on paeonol and lauric acid was constructed and showed potential applicability for the delivery of paeonol.
Jieyu Wu, Suqin Yang, Tianxiang Yin, Xiaoyong Wang   +3 more
openaire   +3 more sources

Albiflorin‐Mediated MAP2K1 Targeting and HIF‐1 Signaling Inhibition Contribute to the Therapeutic Efficacy in Hyperuricemia‐Associated Cognitive Impairment

Human Mutation, Volume 2026, Issue 1, 2026.
This study investigated the therapeutic effects and mechanisms of Paeonia suffruticosa fruit pod extract (EMP) and its main component albiflorin (AF) on hyperuricemia‐associated cognitive impairment (HUA‐CI). A HUA‐CI mouse model was established, with cognitive function evaluated via Morris water maze.
Huimin Xiao, Xinwen Huang, Rui Yao, Jincai Liu, Linrui Duan, Siwang Wang, Jinming Gao, Minghua Ren   +7 more
wiley   +1 more source

Effect of cerebrolysin on oxidative stress-induced apoptosis in an experimental rat model of myocardial ischemia [PDF]

, 2016
Apoptosis plays a role in the process of tissue damage after myocardial infarction (MI). This study was designed to investigate the possible effect of cerebrolysin against apoptosis triggered by oxidative cell stress in myocardial ischemia induced by ...
Acikel, Acikel, Bialik, Bialik, Cheng, Cheng, Deviatkina, Deviatkina, Formichi, Formichi, Galang, Galang, Garg, Garg, Gasparyan, Gasparyan, Gonzalez, Gonzalez, Gustafsson, Gustafsson, Hartbauer, Hartbauer, Heiss, Heiss, Hockenbery, Hockenbery, Hutter-Paier, Hutter-Paier, Keshavarz, Keshavarz, Krijnen, Krijnen, Li, Li, Li, Li, Lie, Lie, Lowry, Lowry, Mathew, Mathew, Misao, Misao, Miyashita, Miyashita, Ohkawa, Ohkawa, Oltvai, Oltvai, Ornellas, Ornellas, Palojoki, Palojoki, Panda, Panda, Patocková, Patocková, Rathore, Rathore, Remiao, Remiao, Ribeiro, Ribeiro, Saraste, Saraste, Senthil, Senthil, Seth, Seth, Sharma, Sharma, Shen, Shen, Singal, Singal, Soussi, Soussi, Sugita, Sugita, Tosaki, Tosaki, Upaganlawar, Upaganlawar, van der Laarse, van der Laarse, von Harsdorf, von Harsdorf, Wang, Wang, Winterbourn, Winterbourn, Xing, Xing, Yue, Yue, Zhu, Zhu   +97 more
core   +1 more source

Orientin Mitigates High Glucose/Ox‐LDL–Triggered Endothelial Cell Injury and Atherosclerosis by Regulating MARCH8‐Mediated NLRP3 Inflammasome Activation

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Endothelial cells under oxidative stress and inflammation are vital contributors to the progression of atherosclerosis. Although Orientin possesses antioxidant and anti‐inflammatory activities, the effects of Orientin on oxidized low‐density lipoprotein and high glucose (ox‐LDL/HG)–triggered endothelial cell injury and diabetes‐accelerated ...
Qi Li, Min Gao, Ni Zhong, Liang-Rong Zhang, Mei-Dong Zhu, Wei-Jing Ge, Qian-Zhu Wang, Xin Chen, Lei Zhang, Fu-Chen Song, Han-Zhi Lu, Fumio Tsuji   +11 more
wiley   +1 more source

Novel thermoresponsive assemblies of co-grafted natural and synthetic polymers for water purification [PDF]

, 2016
Water contamination and its purification are a global problem. The current approach to purify water is reduction of impurities to acceptable levels. One of the ways to achieve this is by use of water-soluble polymers that extract organic and metallic ...
Ambre, Premlata, Barton, Stephen, Chandra, Sudeshna, Coutinho, Evans, Singh Paneysar, Joginder   +4 more
core   +1 more source

Paeonol Suppresses Vasculogenesis Through Regulating Vascular Smooth Muscle Phenotypic Switching

Journal of Endovascular Therapy, 2021
Objective: Smooth muscle cell (SMC) phenotypic switching is associated with development of a variety of occlusive vascular diseases. Paeonol has been reported to be involved in suppressing SMC proliferation. However, it is still unknown whether paeonol can regulate SMC phenotypic switching, and which eventually result in suppressing vasculogenesis ...
Huan Xu, Ziqiang Wu, Zhong Jin, Xiao Wu, Wangming Hu, Bing Liang, Guanhua Lou, Zixian Chen, Huan Yao, Xiongbing Chen, Xin Zhou, Han Xiao, Cenghao Yu, Delai Zhang, Daoying Gong, Lan Yang, Yaping Shi, Yiming Xu, Yong Wang   +18 more
openaire   +2 more sources

Analysis of Chemical Components and Blood‐Absorbed Components in Youjing Granules by UHPLC‐Q‐Orbitrap‐MS

Analytical Science Advances, Volume 6, Issue 2, December 2025.
ABSTRACT This study investigates the chemical components of Youjing Granules (YG) and identifies blood‐absorbed components in rat serum following YG administration via gavage. Chemical components and blood‐absorbed components of YG were analysed and identified using ultra‐high‐performance liquid chromatography coupled with hybrid quadrupole‐orbitrap ...
Mingxin Guo, Jiaqi Zeng, Xuping Jiang, Wenjiao Zhu, Zhian Tang, Tieliang Ma   +5 more
wiley   +1 more source

Integrative Toxicology Profiling of Thuja sutchuenensis Essential Oil: From LD50 Safety Assessment to Hepatic Apoptosis and Gut Microbiota Modulation

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This study provides the first experimental evidence of Thuja sutchuenensis essential oil (TEO) toxicity, with an oral LD50 of ~3800 mg/kg in mice. Sub‐LD50 doses cause focal hepatic necrosis via apoptosis/oxidative stress–related pathways without systemic inflammation or renal injury.
Nana Long, Youwei Zuo, Renxiu Yao, Quan Yang, Jian Li, Xiao Zhang, Shiqi You, Yang Peng, Hongping Deng   +8 more
wiley   +1 more source