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Medical Journal of Australia, 2004 Paget's disease of bone is common, affecting up to 4% of Australians over the age of 55 years. The incidence of the disease and the severity of newly diagnosed cases appear to be falling, for unknown reasons. The cause of Paget's disease is unknown, but there is a strong genetic influence.
David M. Reid, Kumar A. Vinod
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Calcified Tissue International, 2019
Paget's disease of bone (PDB) is a chronic and focal bone disorder, characterized by increased osteoclast-mediated bone resorption and a subsequent compensatory increase in bone formation, resulting in a disorganized mosaic of woven and lamellar bone at one or more affected skeletal sites.
Daniela Merlotti +4 more
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Paget's disease of bone (PDB) is a chronic and focal bone disorder, characterized by increased osteoclast-mediated bone resorption and a subsequent compensatory increase in bone formation, resulting in a disorganized mosaic of woven and lamellar bone at one or more affected skeletal sites.
Daniela Merlotti +4 more
openaire +6 more sources
Orthopedic Clinics of North America, 1990
Paget's disease of bone is defined as a process of increased bone remodeling; the primary event is increased resorption (osteoclastic activity) followed by subsequent reactive bone formation (osteoblastic activity). It is usually asymmetric and may be asymptomatic.
Joseph M. Lane +2 more
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Paget's disease of bone is defined as a process of increased bone remodeling; the primary event is increased resorption (osteoclastic activity) followed by subsequent reactive bone formation (osteoblastic activity). It is usually asymmetric and may be asymptomatic.
Joseph M. Lane +2 more
openaire +3 more sources
Seminars in Musculoskeletal Radiology, 2002
Publisher Summary This chapter focuses on Paget's disease, which is a common disorder of the skeleton that is local in nature and extremely variable in its clinical manifestations. Skeletal deformity and pain are most common symptoms, and deformities are usually most apparent in the skull, face, and lower extremities.
Frederick R. Singer, G. David Roodman
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Publisher Summary This chapter focuses on Paget's disease, which is a common disorder of the skeleton that is local in nature and extremely variable in its clinical manifestations. Skeletal deformity and pain are most common symptoms, and deformities are usually most apparent in the skull, face, and lower extremities.
Frederick R. Singer, G. David Roodman
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Trends in Endocrinology & Metabolism, 2008
Despite significant advances in management, Paget disease remains an enigmatic disorder. There are no animal models, and while its end result --a focal disorder of accelerated bone turnover--is easily recognized, the causes and evolution of the disorder remain uncertain.
Mark J Bolland, Tim Cundy
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Despite significant advances in management, Paget disease remains an enigmatic disorder. There are no animal models, and while its end result --a focal disorder of accelerated bone turnover--is easily recognized, the causes and evolution of the disorder remain uncertain.
Mark J Bolland, Tim Cundy
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Best Practice & Research Clinical Rheumatology, 2003
Paget's disease of bone is characterized by an anarchic bone remodelling, associated with morphological and functional abnormalities of osteoclasts. Its prevalence and incidence rates decreased gradually over the past two decades; the reason for this remains unclear.
Mickaël Rousière +3 more
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Paget's disease of bone is characterized by an anarchic bone remodelling, associated with morphological and functional abnormalities of osteoclasts. Its prevalence and incidence rates decreased gradually over the past two decades; the reason for this remains unclear.
Mickaël Rousière +3 more
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Clinical Biochemistry, 2012
To review recent advance in understanding the causation and management of Paget's disease.We review recent publications concerning the aetiology of the disease and the use of biochemical markers of bone turnover in diagnosis and treatment.Epidemiologic studies suggest that Paget's disease is decreasing in prevalence and severity (implying that ...
Tim Cundy, Ian R. Reid
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To review recent advance in understanding the causation and management of Paget's disease.We review recent publications concerning the aetiology of the disease and the use of biochemical markers of bone turnover in diagnosis and treatment.Epidemiologic studies suggest that Paget's disease is decreasing in prevalence and severity (implying that ...
Tim Cundy, Ian R. Reid
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Clinics in Geriatric Medicine, 1994
Paget's Disease of the bone is the second most common bone disease affecting the older population. Many of its symptoms are often erroneously attributed to the aging process. Its diagnosis is relatively simple. Means are now available to arrest the progress of the disease and restore a normal bone architecture.
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Paget's Disease of the bone is the second most common bone disease affecting the older population. Many of its symptoms are often erroneously attributed to the aging process. Its diagnosis is relatively simple. Means are now available to arrest the progress of the disease and restore a normal bone architecture.
openaire +3 more sources
Orthopedic Clinics of North America, 2015
The current understanding of Paget disease of bone (PDB) has vastly changed since Paget described the first case in 1877. Medical management of this condition remains the mainstay of treatment. Surgical intervention is usually only used in fractures through pagetic bone, need for realignment to correct deformity in major long bones, prophylactic ...
Mamun Al-Rashid +6 more
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The current understanding of Paget disease of bone (PDB) has vastly changed since Paget described the first case in 1877. Medical management of this condition remains the mainstay of treatment. Surgical intervention is usually only used in fractures through pagetic bone, need for realignment to correct deformity in major long bones, prophylactic ...
Mamun Al-Rashid +6 more
openaire +3 more sources
Seminars in Musculoskeletal Radiology, 2016
Paget disease (PD) is a common disease of bone associated with abnormal bone turnover that in turn is due to an imbalance between osteoclastic and osteoblastic activity. There is good evidence that PD is reducing in incidence, prevalence, and severity.
Radhesh Lalam +2 more
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Paget disease (PD) is a common disease of bone associated with abnormal bone turnover that in turn is due to an imbalance between osteoclastic and osteoblastic activity. There is good evidence that PD is reducing in incidence, prevalence, and severity.
Radhesh Lalam +2 more
openaire +3 more sources