Results 21 to 30 of about 11,371 (266)
Tumor-Associated Hypercalcemia in a Patient with Paget's Disease
Kaohsiung Journal of Medical Sciences, 2008 Paget's disease of the bone, which is characterized by a focal region of highly exaggerated bone remodeling, is very rare in Asia. Most patients with Paget's disease are asymptomatic; they are normocalcemic and show elevated alkaline phosphatase levels ...
Hao-Chang Hung +4 more
doaj +1 more source
World Journal of Nuclear Medicine, 2020 Tc-99m methylene diphosphonate bone scintigraphy (bone scan) is a highly sensitive technique for the evaluation of osseous pathology. However, the nonspecificity of the method can present diagnostic challenges in differentiating benign from malignant ...
Robert Devita +2 more
doaj +1 more source
Long-term randomized trial of intensive versus symptomatic management in Paget's disease of bone: The PRISM-EZ study [PDF]
, 2017 It has been suggested that normalization of bone turnover may improve clinical outcome in Paget’s disease of bone (PDB) by preventing complications such as fractures and the progression of osteoarthritis.
Armamento-Villareal +23 more
core +1 more source
The SQSTM1/p62 UBA domain regulates Ajuba localisation, degradation and NF-κB signalling function.
PLoS ONE, 2021 The LIM-domain containing protein Ajuba and the scaffold protein SQSTM1/p62 regulate signalling of NF-κB, a transcription factor involved in osteoclast differentiation and survival.
Melanie A Sultana +8 more
doaj +1 more source
Optineurin functions for optimal immunity [PDF]
, 2018 Optineurin (OPTN) was identified 20 years ago in a yeast-two-hybrid screen with a viral protein known to inhibit the cytolytic effects of tumor necrosis factor.
Slowicka, Karolina, van Loo, Geert
core +1 more source
Boning up on autophagy: the role of autophagy in skeletal biology. [PDF]
, 2013 From an evolutionary perspective, the major function of bone is to provide stable sites for muscle attachment and affording protection of vital organs, especially the heart and lungs (ribs) and spinal cord (vertebrae and intervertebral discs).
Layfield, Robert +4 more
core +2 more sources
Paget's disease of bone: A rare case report
Journal of Indian Academy of Oral Medicine and Radiology, 2020 Paget's disease of bone (PDB) is a localized bone remodeling disorder that is chronic, non-inflammatory.. It is also known as “osteodystrophia deformans” as described by Sir James Paget. PDB is the second most common bone disease after osteoporosis. This
Mohsin M Tak +2 more
doaj +1 more source
BMJ, 1981 The essential requirement for effective treatment of Paget’s disease of bone is that the characteristic abnormality of bone remodelling is predictably corrected without the occurrence of significant side effects. Although the ideal agent is not currently available, appropriate use of the calcitonins or diphosphonates goes a long way to achieving this ...
openaire +2 more sources
An unusual presentation of metastatic bone disease in a subject with Paget's disease of bone
Journal of Family Medicine and Primary Care, 2016 Solid organ malignancies involving breast, prostate, and lung frequently metastasize to the skeleton. However, the occurrence of Paget's disease and metastatic bone disease in the same patient is uncommon.
Shrinath Shetty +5 more
doaj +1 more source
A rare case of orbital osteogenic sarcoma [PDF]
, 1996 Osteogenic sarcoma is a malignant bony tumor of mesenchymal cell ori gin. The association of osteogenic sarcoma with Paget's disease of the bone (osteitis deformans) is well-known.
Fry, CL +3 more
core +1 more source