Results 71 to 80 of about 107,995 (304)

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

Advanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang, Shan Zhang, Junping Bai, Xiaobing Li, Yi Han, Min Ji, Chongyi Jiang, Xiaobei Ge, Tianyu Yu, Yongying Hou, Jun Zhang, Wangting Li, Yiran Song, Jiaying Cai, Yingqun Zhou, Liwei An, Feng Wang   +16 more
wiley   +1 more source

Prognostic Value of Plasminogen Activator Inhibitors in Breast Cancer

The International Journal of Biological Markers, 2002
The prognosis of cancer is primarily dependent on its potential to invade and metastasize. Data from both pre-clinical and clinical studies strongly suggest that serine proteases, as well as their inhibitors and receptor, play a central role in the ...
S. Borstnar MD, I. Vrhovec, T. Cufer
doaj   +1 more source

Interactive Effect of PAI-1 4G/5G Genotype and Salt Intake on PAI-1 Antigen [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2001
Abstract —Activation of the renin-angiotensin-aldosterone system (RAAS) is associated with increased circulating PAI-1 antigen and increased risk of thrombotic cardiovascular events. A 4G/5G polymorphism located 675 bp upstream from the transcription start site of the PAI-1 gene affects PAI-1 antigen ...
N J, Brown, L J, Murphey, N, Srikuma, N, Koschachuhanan, G H, Williams, D E, Vaughan   +5 more
openaire   +2 more sources

Korelacija aktivnosti PAI-1 u plazmi i polimorfizma 4G/5G u genu za PAI-1 [PDF]

, 2016
Hemostaza obuhvaća složene, međusobno povezane sustave čija je zadaća održati fluidnost krvi u tekućem stanju u krvožilnom sustavu, ali i omogućiti brzo stvaranje krvnog ugruška nakon ozljede krvne žile.
Čolić, Merima
core   +1 more source

Interfacial Engineering by Metallic Ions and Organic Ammonium Ligand Passivation for Perovskite Solar Cells

Advanced Science, EarlyView.
A synergistic approach using phenethylammonium iodide (PEAI) and antimony iodide (SbI3) enhances the operational stabilities of perovskite solar cells by providing p‐type doping effect, suitable band energy alignment, reduced defect density, and minimized surface ion vacancies in the perovskite films.
Abraham Adenle, Purevlkham Myagmarsereejid, Selengesuren Suragtkhuu, Tuul Tsagaantsooj, Solongo Purevdorj, Eric Campbell, Sina Jamali, Oisín E. FitzGerald, Taylor J. Z. Stock, Thomas J. Macdonald, Joseph F. S. Fernando, Hui Jin, Paul E. Shaw, Michitoshi Hayashi, Batjargal Sainbileg, Chihaya Adachi, Yu Lin Zhong, Munkhbayar Batmunkh   +17 more
wiley   +1 more source

High-intensity interval training modulates thrombotic susceptibility in metabolic syndrome: Attenuation of plasma PAI-1 and fibrinogen via ameliorated metabolic dysfunction [PDF]

Journal of Exercise & Organ Cross Talk
Metabolic syndrome (MetS) elevates thrombotic risk through dysregulated coagulation factors, including plasminogen activator inhibitor-1 (PAI-1) and fibrinogen, driven by visceral adiposity and metabolic dysfunction.
Niyousha Ghazbani, Arezoo Razmdideh, Amin Alimohammadi, Danial Bagherzadeh, Ehsan Rezaee Moeini, Mohammad Reza Mozaffari, Mohammad Sadra Roshani Koosha   +6 more
doaj   +1 more source

Precision targeting of the plasminogen activator inhibitor‐1 mechanism increases efficacy of fibrinolytic therapy in empyema

Physiological Reports, 2021
Plasminogen activator inhibitor‐1 (PAI‐1) is an endogenous irreversible inhibitor of tissue‐type (tPA) and urokinase (uPA) plasminogen activators. PAI‐1‐targeted fibrinolytic therapy (PAI‐1‐TFT) is designed to decrease the therapeutic dose of tPA and uPA,
Galina Florova, René A. Girard, Ali O. Azghani, Krishna Sarva, Ann Buchanan, Sophia Karandashova, Christian J. DeVera, Danna Morris, Mignote Chamiso, Kathleen Koenig, Douglas B. Cines, Steven Idell, Andrey A. Komissarov   +12 more
doaj   +1 more source

Bifunctional Artificial Enzymes‐Loaded Microgels With LOX‐ and CAT‐Like Activities for Metabolic Reprogramming and Scarless Wound Repair

Advanced Science, EarlyView.
A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang, Pai Peng, Liang Song, Qiaoxuan Wang, Zilong Zhong, Dongchao Qiu, Yunfan Liu, Kefei Zhao, Xiaofei Dong, Changyou Gao   +9 more
wiley   +1 more source

PAI-1 and TGF-β [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2006
Atherosclerosis is an extremely complex disease process in which genetic, lipid, cellular, and immunologic factors combine to determine the location, severity, and timing of lesion development and clinical events.1 With the current epidemic of obesity and the metabolic syndrome, additional factors are now recognized as contributors to the vascular ...
openaire   +1 more source

Lipoatrophy of the footpad in HIV-treated patients is associated with increased PAI-1 [PDF]

, 2011
Purpose: To describe lipoatrophy of the plantar pedis fat pads in HIV patients with or without long-term antiretroviral therapy (ART); to compare the characteristics of ART patients with and without plantar pedis lipoatrophy; and to examine the effects ...
Guaraldi, G., Göran A. Bratt, Lars E. Eriksson, Lena Nilsson Schönnesson, Moyle, G.J., Stupar, M.   +5 more
core   +1 more source