Results 101 to 110 of about 466,886 (231)

Neuropeptide Alterations in Type 2 Diabetes Mellitus: A Meta‐Analysis of Circulating Spexin and Galanin Levels

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
This systematic review and meta‐analysis demonstrates that circulating spexin levels are significantly reduced, whereas galanin levels are significantly elevated, in patients with type 2 diabetes mellitus. Despite their potential as biomarkers of metabolic dysregulation, the current evidence remains of very low certainty. ABSTRACT Background Spexin and
Roshan Kumar Mahat, Sushil Yadav, Kahkashan Naaz, Nand Kishor Prasad Sah, Amrendra P. Kushwaha   +4 more
wiley   +1 more source

Painful diabetic neuropathy—new choice of first-line therapy?

, 2011
Painful diabetic neuropathy is a common complication of diabetes mellitus. Based on strong evidence, recently published guidelines suggest that pregabalin should be offered as first-line therapy in patients with painful symptoms.
Tentolouris, Nicholas K., Nicholas K. Tentolouris   +1 more
core   +2 more sources

Pain Management in Erythromelalgia: A Systematic Review and Graded Appraisal Across Etiological Subtypes

European Journal of Pain, Volume 30, Issue 8, September 2026.
ABSTRACT Introduction Erythromelalgia is a rare disorder characterised by burning pain, erythema and increased skin temperature in the extremities. Its pathophysiological heterogeneity, together with variable treatment responses, complicates management in the absence of evidence‐based guidelines.
Camille Racca, Sarah Berthelot, Julia Franken, Marion Licois, Ada Du Pasquier, Ihssene Djidjeli, Laura Esteve, Eric Serra, Xavier Moisset   +8 more
wiley   +1 more source

Contextual Modulation of Fronto‐Central, Parietal, and Global Peak Alpha Frequency

European Journal of Pain, Volume 30, Issue 8, September 2026.
ABSTRACT Background Peak alpha frequency (PAF), the dominant frequency in the alpha band (8–12 Hz), has been proposed as a biomarker of pain sensitivity, but mixed findings may reflect broad sensory and cognitive influences on PAF. Operant conditioning can modulate pain perception and related brain activity, but its effect on PAF has not been explored.
Carolina Ceruti, Laura Petrini, Elia Valentini, Michelle Bonvini, Giulia Erica Aliotta, Kristian Hennings, Carsten Dahl Mørch, Dennis Boye Larsen   +7 more
wiley   +1 more source

Eleven neurology-related proteins measured in serum are positively correlated to the severity of diabetic neuropathy

Scientific Reports
About 20% of patients with diabetes suffer from chronic pain with neuropathic characteristics. We investigated the multivariate associations between 92 neurology-related proteins measured in serum from 190 patients with painful and painless diabetic ...
Emmanuel Bäckryd, Andreas Themistocleous, Anders Larsson, Torsten Gordh, Andrew S. C. Rice, Solomon Tesfaye, David L. Bennett, Björn Gerdle   +7 more
doaj   +1 more source

Diabetic neuropathies: update on definitions, diagnostic criteria, estimation of severity, and treatments.

, 2010
Preceding the joint meeting of the 19th annual Diabetic Neuropathy Study Group of the European Association for the Study of Diabetes (NEURODIAB) and the 8th International Symposium on Diabetic Neuropathy in Toronto, Canada, 13-18 October 2009, expert ...
Lauria G, Kempler P, Tesfaye S, Malik RA, Horowitz M, Spallone V, Freeman R, Vinik A, Dyck PJ, Boulton AJ, Valensi P, BERNARDI, LUCIANO, Toronto Diabetic Neuropathy Expert Group   +12 more
core  

Inherited microcytic anemias due to disorders of iron and heme metabolism: An updated clinical review

HemaSphere, Volume 10, Issue 9, September 2026.
Abstract Microcytic anemia is among the most common hematological abnormalities in clinical practice and is usually attributable to iron deficiency, thalassemia traits, or anemia of inflammation. A small but clinically important subset of patients, however, has inherited disorders of iron metabolism or heme synthesis presenting with persistent ...
Alexandros Makis, Ioanna Saougou, Eleftheria Hatzimichael   +2 more
wiley   +1 more source

Preservation of Nociceptor Intraepidermal Nerve Fibres in Diabetic Neuropathic Pain

Journal of Diabetes Research
Peripheral painful sensory neuropathy represents a prevalent and disabling complication of Type 1 and Type 2 diabetes. Unfortunately, despite the clinical need for improved analgesic approaches, clinicians remain inadequately provisioned to treat these ...
Lisa A. Lione, Lydia D. Hardowar, Michael T. Lanigan, Jessica Bates, William Blackstone-Whines, Harry Jones, Richard P. Hulse   +6 more
doaj   +1 more source

AI‐Enhanced System for Diabetic Foot Ulcer Localization and Classification Using Multi‐Scale Neural CNN Model

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Diabetic foot ulcers (DFUs), which heal slowly because of inadequate blood supply, are among the serious infections and chronic foot problems that can result from diabetes mellitus (DM). The primary consequence of DFU, which can result in amputation if left untreated.
Md. Nur‐A‐Alam, Md. Anwar Hussen Wadud, Mostofa Kamal Nasir, Khandaker Mohammad Mohi Uddin   +3 more
wiley   +1 more source

Association between periodontitis and oral health–related quality of life in patients with systemic conditions: A meta‐analysis

Journal of Periodontology, Volume 97, Issue 9, Page 1990-2002, September 2026.
Abstract Background The objective of this systematic review is to evaluate whether periodontitis is associated with impaired oral health–related quality of life (OHRQoL) in adults with systemic conditions. Methods Five databases were searched to identify observational studies that tested the association between periodontitis (diagnosed by clinical ...
Rafael Vargas Bortolaso, Catiusse Crestani Del' Agnese, Leandro Machado Oliveira, Patricia A. Miguez, Fabricio Batistin Zanatta, Raquel Pippi Antoniazzi   +5 more
wiley   +1 more source