Results 61 to 70 of about 464,659 (356)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Perspectives of telemedicine-based services among family caregivers of patients with end-of-life cancer: a qualitative study in mainland China

BMC Palliative Care
Background Despite being driven by a strong sense of duty and familial obligation, providing care for patients nearing the end of life poses challenges for family caregivers.
Junchen Guo, Xianghua Xu, Chaoyi Liu, Ying Wang, Yongyi Chen   +4 more
doaj   +1 more source

Whither Palliative Care?

Current Oncology, 2019
Palliative care (pc) has evolved from a field of medicine devoted exclusively to end-of-life care into one that focuses on symptom management and quality of life throughout terminal illness.[...]
Watt, C.L., Downar, J.
openaire   +2 more sources

End-of-life care for non-cancer patients [PDF]

, 2013
[Extract]: The origins and early development of palliative care focussed on patients with cancer, apart from sporadic developments in a few non-malignant diseases such as MND and HIV.
Boland, Jason, Johnson, Miriam J.
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A National Quality Initiative to Improve Palliative Care Outcomes: Identifying Enabling Factors that Drive Quality Improvement

Palliative Medicine Reports
Background: The Palliative Care Outcomes Collaboration (PCOC), established in 2005 and funded by the Australian Government, is a national quality improvement initiative that integrates patient outcome measures into routine clinical practice.
Sabina Clapham, Katherine Clark, Kylie Draper, Fiorina Mastroianni, Jesse Rand, Lisa Redwood, David Currow   +6 more
doaj   +1 more source

Communication in the face of death and dying - how does the encounter with death influence the patient management competence of medical students? An outcome-evaluation

BMC Medical Education, 2022
Background information As part of an elective course, the Interdisciplinary Centre for Palliative Medicine at Duesseldorf University Hospital offers medical students the opportunity to personally meet and talk to a seriously ill patient on one or more ...
T. Thyson, M. Schallenburger, A. Scherg, A. Leister, J. Schwartz, M. Neukirchen   +5 more
doaj   +1 more source

Development of a patient-reported palliative care-specific health classification system: the POS-E [PDF]

, 2017
BackgroundGeneric preference-based measures are commonly used to estimate quality-adjusted life-years (QALYs) to inform resource-allocation decisions.
Dzingina, Mendwas, Higginson, Irene J., McCrone, Paul, Murtagh, Fliss, Murtagh, Fliss E. M., Murtagh, Fliss E.M.   +5 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Prognostic awareness and its association with health outcomes in the last year of life

Cancer Medicine, 2023
Background Little research has examined changes in prognostic awareness (PA) in the last year of life and the extent PA change was associated with anxiety, depression, and spiritual well‐being among metastatic cancer patients.
Semra Ozdemir, Isha Chaudhry, Sean Ng, Irene Teo, Chetna Malhotra, Eric Andrew Finkelstein, COMPASS Study Group   +6 more
doaj   +1 more source