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Mechanism of the Proprietary Chinese Medicine "JiuLiWan" to Treat Ulcerative Colitis Revealed by Network Pharmacology, Molecular Docking, and Experimental Verification <i>In Vitro</i>. [PDF]
ACS OmegaLiao Z +13 more
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Palmatine: A review of its pharmacology, toxicity and pharmacokinetics
Biochimie, 2019Palmatine is a natural isoquinoline alkaloid and has been widely used in pharmaceutical field. The purpose of this review is to provide the latest and comprehensive information on the pharmacology, toxicity and pharmacokinetics of palmatine in the past, to explore the therapeutic potential of this compound and look for ways to reduce toxicity ...
Jiaying Long +2 more
exaly +3 more sources
Inhibition of tyrosine hydroxylase by palmatine
Archives of Pharmacal Research, 1996Palmatine, an protoberberine isoquinoline alkaloid, has been found to inhibit dopamine biosynthesis by reducing tyrosine hydroxylase (TH) activity in PC12 cells (Lee and Kim, 1996). We have therefore investigated the effects of palmatine on bovine adrenal TH.
Myung Koo Lee, Lee Myung Koo
exaly +2 more sources
Metabolism of palmatine by human hepatocytes and recombinant cytochromes P450
Journal of Pharmaceutical and Biomedical Analysis, 2015In this study, we developed a new liquid chromatography-mass spectrometry (LC-MS) method for analysis of the protoberberine alkaloid palmatine and its metabolites with separation performed on a cyanopropyl-modified stationary phase. Palmatine (10 μM) was metabolized using suspensions of human hepatocytes and human recombinant cytochrome P450 (CYP ...
Barbora Papoušková +2 more
exaly +3 more sources
Determination of the specific interaction between palmatine and bovine serum albumin
Molecular Biology Reports, 2011The binding of palmatine to bovine serum albumin (BSA) was studied under physiological conditions (pH = 7.40) by molecular spectroscopic approach. It was proved that the fluorescence quenching of BSA by palmatine is a result of the formation of palmatine-BSA complex.
Yan-Jun Hu, Yu Ou-Yang, Hu Yan-Jun
exaly +3 more sources
Journal of Structural Chemistry, 2022
With the aim to improve the hygroscopic stability of palmatine chloride (PMTCl), an unreported single crystal of PMT—SSA (C21H20NO4·C7H5O6S·H2O) is prepared by the solvent evaporation method and characterized. A comprehensive analysis of the structure and Hirshfeld surface reveals that π—π stacking plays a crucial role in accumulating PMT—SSA.
Yu-Nan Zhang +10 more
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With the aim to improve the hygroscopic stability of palmatine chloride (PMTCl), an unreported single crystal of PMT—SSA (C21H20NO4·C7H5O6S·H2O) is prepared by the solvent evaporation method and characterized. A comprehensive analysis of the structure and Hirshfeld surface reveals that π—π stacking plays a crucial role in accumulating PMT—SSA.
Yu-Nan Zhang +10 more
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Palmatine and Berberine Isolation Artifacts
Journal of Natural Products, 2003Some 8-substituted derivatives of the protoberberine alkaloids palmatine (1a) and berberine (1b) have been prepared and investigated by 1D and 2D NMR spectroscopy (H-1, C-13, N-15). Complete NMR data for the 8-hydroxy (2), 8-methoxy (3), 8-ethoxy (4), and 8-trichloromethyl (5) 7,8-dihydro derivatives of 1a and 1b, as well as X-ray data for 8 ...
Radek, Marek +5 more
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Biosynthesis of tetrahydropalmatine and palmatine
Tetrahedron, 1980Abstract The incorporation of (±)-norlaudanosoline, norprotosinomenine, nororientaline, norlaudanidine, reticuline and laudanosine into tetrahydropalmatine and palmatine has been studied, and specific utilization of reticuline demonstrated. Feeding of (±)-[N-methyl-14C] reticuline showed that C atom 8 of tetrahydropalmatine and palmatine are formed ...
Dewan S. Bhakuni +2 more
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Palmatine: A review of pharmacological properties and pharmacokinetics
Phytotherapy Research, 2019The aim of this review is to collect together the results of the numerous studies over the last two decades on the pharmacological properties of palmatine published in scientific databases like Scopus and PubMed, which are scattered across different publications.
Dominik Tarabasz, Wirginia Kukula‐Koch
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