Results 91 to 100 of about 5,176,832 (349)
Advanced Science, EarlyView.In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia +11 more
wiley +1 more source
Stages of uptake and incorporation of micellar palmitic acid by hamster proximal intestinal mucosa
Journal of Lipid Research, 1972 The stages of uptake and incorporation of micellar palmitic acid by hamster proximal intestinal mucosa were investigated by incubation of everted sacs at 4°C and 37°C for 2, 5, 10, and 15 min in a micellar solution (10 μmoles of [l-14C]palmitic acid, 10 ...
Seymour Mishkin +2 more
doaj +1 more source
Differential Lipid Accumulation on HepG2 Cells Triggered by Palmitic and Linoleic Fatty Acids Exposure [PDF]
, 2023 Francisca S. Teixeira +5 more
openalex +1 more source
Normalization of Essential-Fatty-Acid-Deficient Keratinocytes Requires Palmitic Acid
Journal of Investigative Dermatology, 1994 Cultured adult human keratinocytes show accelerated growth rates in medium that is essential fatty acid deficient. The cells also show decreased amounts of the essential fatty acids 18:2, 20:3, and 20:4 and contain increased amounts of the monounsaturated fatty acids 16:1 and 18:1.
Marcelo, Cynthia L +2 more
openaire +2 more sources
Advanced Science, EarlyView.Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang +14 more
wiley +1 more source
The Ferroptosis Induced by Palmitic Acid via CD36 Activating ER Stress to Break Calcium-Iron Balance in Colon Cancer Cells [PDF]
, 2023 Hui Kuang, Tao Li
openalex +1 more source
Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex
Advanced Science, EarlyView.In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang +13 more
wiley +1 more source
BioResources, 2015 Methylated fatty acid (FA) compounds in the heartwood and bark of some softwood species, specifically Pinus sylvestris, Abies alba, Picea abies, and Larix decidua, grown in the Czech Republic were evaluated.
Mohamed Zidan Mohamed Salem +7 more
doaj +1 more source
A primary effect of palmitic acid on mouse oocytes is the disruption of the structure of the endoplasmic reticulum [PDF]
, 2021 Yisu Wang +6 more
openalex +1 more source
F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway
Advanced Science, EarlyView.In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu +16 more
wiley +1 more source