Results 91 to 100 of about 81,377 (299)

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

open access: yesHepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan   +22 more
wiley   +1 more source

The Stability of Palmitic Acid Monolayers [PDF]

open access: yes, 2017
Sea spray aerosols, naturally-generated aerosols originating from the sea surface microlayer, affect the climate in a myriad of ways. To study the stability of the organic coatings on sea spray aerosols, palmitic acid monolayers served as a model system ...
Vidalis, Andrew
core  

Effect of Palmitic Acid on the Electrical Conductivity of Carbon Nanotubes−Epoxy Resin Composites [PDF]

open access: yes, 2003
We found that the palmitic acid allows an efficient dispersion of carbon nanotubes in the epoxy matrix. We have set up an experimental protocol in order to enhance the CNTs dispersion in epoxy resin. Electrical conductivity is optimal using a 1:1 CNTs to
Laurent, Christophe   +5 more
core   +1 more source

ZDHHC17‐Mediated CDK4 Palmitoylation Drives Cell Cycle Progression and Orchestrates Cancer Immune Surveillance

open access: yesAdvanced Science, EarlyView.
ZDHHC17 palmitoylates CDK4, which together with TRAF6‐mediated ubiquitination, drives cell cycle progression and immune surveillance, revealing a rational combination of CDK4 inhibitors with immune checkpoint blockers for ZDHHC17‐driven cancers. ABSTRACT Uncontrolled cell cycle progression is a hallmark of cancer, tightly regulated by both intrinsic ...
Zekang Wang   +7 more
wiley   +1 more source

Quantitative Photo‐Reforming of Biomass to CO Spurred by In Situ Protonation of Carbon Dioxide Radical Anions

open access: yesAngewandte Chemie, EarlyView.
A “two‐in‐one” photoreduction strategy enabled by electron‐rich yolk Cd species both remote from and adjacent to sulfur vacancies is delivered to be ultraselective for the reduction of O2 and •CO2− in situ formed on the shell Bi2S3 composition (hole) by water oxidation and oxidative C–C cleavage of various biomass organic acids, furnishing CO with > 99%
Tengyu Liu   +5 more
wiley   +2 more sources

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

open access: yesHepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai   +29 more
wiley   +1 more source

A mutant of Brassica napus with increased palmitic acid content

open access: yes, 2000
An induced mutant from European winter oilseed rape with increased palmitic acid content was phenotypically characterized and genetically analysed. The mutant showed a palmitic acid content of 9.2% compared with 4.5% in the parental cultivar.
Mollers, C.   +2 more
core   +1 more source

Targeting ANGPTL3 and IL‐33/ST2 Ameliorates Diabetic Kidney Disease by Reducing Lipotoxicity, Alleviating Inflammation and Inhibiting Fibrosis

open access: yesAdvanced Science, EarlyView.
Dual targeting of ANGPTL3 and IL‐33/ST2 attenuates diabetic kidney disease by reprogramming lipid–inflammatory crosstalk. This strategy reduces renal lipotoxicity, suppresses inflammatory activation, and limits fibrotic remodeling, thereby preserving kidney structure and function and highlighting a mechanism‐guided therapeutic approach for metabolic ...
Zhuojin Li   +8 more
wiley   +1 more source

Methylated Fatty Acids from Heartwood and Bark of Pinus sylvestris, Abies alba, Picea abies, and Larix decidua: Effect of Strong Acid Treatment

open access: yesBioResources, 2015
Methylated fatty acid (FA) compounds in the heartwood and bark of some softwood species, specifically Pinus sylvestris, Abies alba, Picea abies, and Larix decidua, grown in the Czech Republic were evaluated.
Mohamed Zidan Mohamed Salem   +7 more
doaj   +1 more source

ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang   +9 more
wiley   +1 more source

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