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Role of Lipotoxicity in Endothelial Dysfunction [PDF]
Heart Failure Clinics, 2012 Vascular endothelial dysfunction is determined by both genetic and environmental factors that cause decreased bioavailability of the vasodilator nitric oxide.
Jeong-A Kim +2 more
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Lipotoxicity and immunometabolism in ischemic acute kidney injury: current perspectives and future directions [PDF]
Frontiers in PharmacologyDysregulated lipid metabolism is implicated in the pathophysiology of a range of kidney diseases. The specific mechanisms through which lipotoxicity contributes to acute kidney injury (AKI) remain poorly understood. Herein we review the cardinal features
Afolarin A. Otunla +3 more
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The Contribution of Lipotoxicity to Diabetic Kidney Disease
Cells, 2022 Lipotoxicity is a fundamental pathophysiologic mechanism in diabetes and non-alcoholic fatty liver disease and is now increasingly recognized in diabetic kidney disease (DKD) pathogenesis.
Jeffrey R. Schelling
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Characterization of regulatory transcriptional mechanisms in hepatocyte lipotoxicity [PDF]
Scientific Reports, 2022 Non-alcoholic fatty liver disease is a continuum of disorders among which non-alcoholic steatohepatitis (NASH) is particularly associated with a negative prognosis. Hepatocyte lipotoxicity is one of the main pathogenic factors of liver fibrosis and NASH.
Joaquín Pérez-Schindler +5 more
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Lipotoxicity and Diabetic Nephropathy: Novel Mechanistic Insights and Therapeutic Opportunities [PDF]
International Journal of Molecular Sciences, 2020 Lipotoxicity is characterized by the ectopic accumulation of lipids in organs different from adipose tissue. Lipotoxicity is mainly associated with dysfunctional signaling and insulin resistance response in non-adipose tissue such as myocardium, pancreas,
Lucas Opazo-Ríos +2 more
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Lipotoxicity in the heart [PDF]
Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids, 2010 Obesity and insulin resistance are associated with ectopic lipid deposition in multiple tissues, including the heart. Excess lipid may be stored as triglycerides, but are also shunted into non-oxidative pathways that disrupt normal cellular signaling leading to organ dysfunction and in some cases apoptosis, a process termed lipotoxicity.
Adam R Wende, E Dale Abel
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Journal of Pharmaceutical Analysis, 2021 Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C (CPT1C), a mitochondrial enzyme
Huizhen Zhang +8 more
doaj +2 more sources
Zearalenone causes female reproductive lipotoxicity through the ERα-CD36/TLR4 signaling pathway [PDF]
Communications BiologyExposure to zearalenone (ZEN), an estrogen-like mycotoxin produced by Fusarium fungi, impairs reproductive performance and farm-animal welfare; however, the underlying mechanism remains unclear. Using female pigs as the large animal model, we demonstrate
Chao Dai +9 more
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Acta Pharmaceutica Sinica BLipotoxicity is a pivotal factor that initiates and exacerbates liver injury and is involved in the development of metabolic-associated fatty liver disease (MAFLD). However, there are few reported lipotoxicity inhibitors.
Yong Rao, Xingxing Chai
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New Aspects of Lipotoxicity in Nonalcoholic Steatohepatitis
International Journal of Molecular Sciences, 2018 NASH is becoming increasingly common worldwide because of the growing global prevalence of obesity and consequently NAFLD. Unfortunately, the mechanism of progression of NAFLD to NASH and then cirrhosis is not completely understood.
Nahum Méndez-Sánchez +2 more
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