Results 11 to 20 of about 28,679 (286)
CD36-mediated podocyte lipotoxicity promotes foot process effacement
Open MedicineLipid metabolism disorders lead to lipotoxicity. The hyperlipidemia-induced early stage of renal injury mainly manifests as podocyte damage. CD36 mediates fatty acid uptake and the subsequent accumulation of toxic lipid metabolites, resulting in podocyte
Hua Wei +11 more
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Lipotoxicity and the role of maternal nutrition [PDF]
Acta Physiologica, 2014 Intrauterine malnutrition predisposes the offspring towards the development of type 2 diabetes and cardiovascular disease. To explain this association, the Developmental Origins of Health and Disease (DOHaD) hypothesis was introduced, meaning that subtle
van Ewijk, P.A. +8 more
core +5 more sources
Lipotoxicity in Kidney, Heart, and Skeletal Muscle Dysfunction
Nutrients, 2019 Dyslipidemia is a common nutritional and metabolic disorder in patients with chronic kidney disease. Accumulating evidence supports the hypothesis that prolonged metabolic imbalance of lipids leads to ectopic fat distribution in the peripheral organs ...
Hiroshi Nishi +2 more
exaly +2 more sources
The Vicious Cycle of Renal Lipotoxicity and Mitochondrial Dysfunction
Frontiers in Physiology, 2020 The kidney is one of the most energy-demanding organs that require abundant and healthy mitochondria to maintain proper function. Increasing evidence suggests a strong association between mitochondrial dysfunction and chronic kidney diseases (CKDs ...
Mengyuan Ge +6 more
doaj +2 more sources
Coadministration of linolenic acid and linoleic acid decreased lipotoxicity in cardiomyocytes.
فصلنامه دانشگاه علوم پزشکی جهرم, 2018 Background: Deleterious effects of lipid accumulation in non-adipose tissues are known as lipotoxicity. The prevalence of cardiovascular disease due to lipotoxicity has been dramatically increased worldwide.
Elham Zadeh Hashem +2 more
doaj +1 more source
BiologyOvernutrition, driven by the consumption of high-fat, high-sugar diets, has reached epidemic proportions and poses a significant global health challenge.
Vivek Mann +2 more
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Stable Isotope-Labeled Lipidomics to Unravel the Heterogeneous Development Lipotoxicity
Molecules, 2018 Non-alcoholic fatty liver disease (NAFLD) as a global health problem has clinical manifestations ranging from simple non-alcoholic fatty liver (NAFL) to non-alcoholic steatohepatitis (NASH), cirrhosis, and cancer.
Lu-Min Shih +5 more
doaj +2 more sources
Lipotoxicity: A New Perspective in Type 2 Diabetes Mellitus
Diabetes, Metabolic Syndrome and ObesityBiaohua Chen,1,2,* Tiangang Li,1,2,* Yingli Wu,1,2,* Liyun Song,1,2 Yinying Wang,1,2 Yao Bian,1,2 Yong Qiu,1,2 Zhongshan Yang1,2 1Yunnan Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Chronic Disease in ...
Chen B +7 more
doaj +2 more sources
Podocyte Lipotoxicity in CKD [PDF]
Kidney360, 2021 CKD represents the ninth most common cause of death in the United States but, despite this large health burden, treatment options for affected patients remain limited. To remedy this, several relevant pathways have been identified that may lead to novel therapeutic options.
Jin-Ju, Kim +2 more
openaire +2 more sources