Results 21 to 30 of about 28,679 (286)

Polyunsaturated Phospholipids Increase Cell Resilience to Mechanical Constraints

Cells, 2021
If polyunsaturated fatty acids (PUFAs) are generally accepted to be good for health, the mechanisms of their bona fide benefits still remain elusive. Membrane phospholipids (PLs) of the cardiovascular system and skeletal muscles are particularly enriched
Linette Kadri, Amélie Bacle, Spiro Khoury, Clarisse Vandebrouck, Jocelyn Bescond, Jean-François Faivre, Thierry Ferreira, Stéphane Sebille   +7 more
doaj   +1 more source

Lipidomic Profile Analysis of Lung Tissues Revealed Lipointoxication in Pulmonary Veno-Occlusive Disease

Biomolecules, 2022
Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary arterial hypertension (PAH) occurring in a heritable form (hPVOD) due to biallelic inactivating mutations of EIF2AK4 (encoding GCN2, general control nonderepressible 2) or in a sporadic ...
Spiro Khoury, Antoine Beauvais, Jenny Colas, Anaïs Saint-Martin Willer, Frédéric Perros, Marc Humbert, Clarisse Vandebrouck, David Montani, Thierry Ferreira, Fabrice Antigny   +9 more
doaj   +1 more source

Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases

Biomolecules, 2023
Lipids, especially lysophosphatidylcholine LPC16:0, have been shown to be involved in chronic joint pain through the activation of acid-sensing ion channels (ASIC3).
Spiro Khoury, Jenny Colas, Véronique Breuil, Eva Kosek, Aisha S. Ahmed, Camilla I. Svensson, Fabien Marchand, Emmanuel Deval, Thierry Ferreira   +8 more
doaj   +1 more source

Lipotoxic Proximal Tubular Injury: A Primary Event in Diabetic Kidney Disease

Frontiers in Medicine, 2021
The pathogenesis of diabetic nephropathy is a complex process that has a great relationship with lipotoxicity. Since the concept of “nephrotoxicity” was proposed, many studies have confirmed that lipotoxicity plays a significant role in the progression ...
Hua Wang, Shu Zhang, Jia Guo, Jia Guo
doaj   +1 more source

A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction

Disease Models & Mechanisms, 2020
The balance within phospholipids (PLs) between saturated fatty acids and monounsaturated or polyunsaturated fatty acids is known to regulate the biophysical properties of cellular membranes.
Amélie Bacle, Linette Kadri, Spiro Khoury, Romain Ferru-Clément, Jean-François Faivre, Christian Cognard, Jocelyn Bescond, Amandine Krzesiak, Hugo Contzler, Nathalie Delpech, Jenny Colas, Clarisse Vandebrouck, Stéphane Sébille, Thierry Ferreira   +13 more
doaj   +1 more source

Exercise inhibits JNK pathway activation and lipotoxicity via macrophage migration inhibitory factor in nonalcoholic fatty liver disease

Frontiers in Endocrinology, 2022
The macrophage migration inhibitory factor (MIF) expressed in hepatocytes can limit steatosis during obesity. Lipotoxicity in nonalcoholic fatty liver disease is mediated in part by the activation of the stress kinase JNK, but whether MIF modulates JNK ...
Ni Cui, Hui Li, Yaoshan Dun, Yaoshan Dun, Yaoshan Dun, Jeffrey W. Ripley-Gonzalez, Baiyang You, Baiyang You, Dezhao Li, Yuan Liu, Ling Qiu, Cui Li, Suixin Liu, Suixin Liu   +13 more
doaj   +1 more source

Lipotoxicity-induced STING1 activation stimulates MTORC1 and restricts hepatic lipophagy

, 2021
Lipid accumulation often leads to lipotoxic injuries to hepatocytes, which can cause nonalcoholic steatohepatitis. The association of inflammation with lipid accumulation in liver tissue has been studied for decades; however, key mechanisms have been ...
Yingqi Huang (11267465), Yao Wang (102387), Xiusheng Qiu (11267468), Jun Cui (38349), Xin Jia (383601), Cong Du (2702083), Yunfei Qin (11267471), Xue Liang (449130), Dongbo Qiu (4927330), Zhendong Xiao (6332369), Kunpeng Liu (5152934), Qi Zhang (28502), Jingyuan Zhao (811333), Kun Li (277035)   +13 more
core   +1 more source

Mitochondrial dysfunction and lipotoxicity [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010
Mitochondrial dysfunction in skeletal muscle has been suggested to underlie the development of insulin resistance and type 2 diabetes mellitus. Reduced mitochondrial capacity will contribute to the accumulation of lipid intermediates, desensitizing insulin signaling and leading to insulin resistance.
Schrauwen, P., Schrauwen-Hinderling, V.B., Hoeks, J., Hesselink, M.K.   +3 more
openaire   +3 more sources

Ferulic acid alleviates lipotoxicity-induced hepatocellular death through the SIRT1-regulated autophagy pathway and independently of AMPK and Akt in AML-12 hepatocytes

Nutrition & Metabolism, 2021
Background Lipotoxicity-induced cell death plays a detrimental role in the pathogenesis of metabolic diseases. Ferulic acid, widespread in plant-based food, is a radical scavenger with multiple bioactivities. However, the benefits of ferulic acid against
Tiantian Xu, Qing Song, Li Zhou, Wenwen Yang, Xiangyao Wu, Qianyu Qian, Hui Chai, Qiang Han, Hongzhi Pan, Xiaobing Dou, Songtao Li   +10 more
doaj   +1 more source

Oxidative Stress Induced by Lipotoxicity and Renal Hypoxia in Diabetic Kidney Disease and Possible Therapeutic Interventions: Targeting the Lipid Metabolism and Hypoxia

Antioxidants, 2023
Oxidative stress, a hallmark pathophysiological feature in diabetic kidney disease (DKD), arises from the intricate interplay between pro-oxidants and anti-oxidants. While hyperglycemia has been well established as a key contributor, lipotoxicity emerges
Seung Yun Chae, Yaeni Kim, Cheol Whee Park   +2 more
doaj   +1 more source