The role of lipotoxicity in cardiovascular disease
, 2022 . Fatty acids are the primary fuel for cardiac muscle. The physiological equilibrium of lipid uptake and oxidation may aid in the prevention of excessive lipid accumulation.
Chuanbao Li +3 more
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Frontiers in Pharmacology, 2021 The occurrence of lipotoxicity during obesity-associated cardiomyopathy is detrimental to health. Salvianolic acid A (SAA), a natural polyphenol extract of Salvia miltiorrhiza Bunge (Danshen in China), is known to be cardioprotective.
Zhen Yang +15 more
doaj +1 more source
DataSheet3_Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway.ZIP
, 2022 Aims: Cardiac lipotoxicity is the common consequence of lipid metabolism disorders in cardiomyocytes during development of heart failure (HF). Adenosine 5′monophosphate-activated protein kinase (AMPK) acts as an energy sensor and has a beneficial effect ...
Xue Tian (417237) +12 more
core +1 more source
Mechanisms of palmitate-induced cell death in human osteoblasts
Biology Open, 2013 Summary Lipotoxicity is an overload of lipids in non-adipose tissues that affects function and induces cell death. Lipotoxicity has been demonstrated in bone cells in vitro using osteoblasts and adipocytes in coculture.
Krishanthi Gunaratnam +4 more
doaj +1 more source
Melatonin as a Repairing Agent in Cadmium- and Free Fatty Acid-Induced Lipotoxicity
Biomolecules, 2023 (1) Background: Cadmium (Cd) is a potentially toxic element with a long half-life in the human body (20–40 years). Cytotoxicity mechanisms of Cd include increased levels of oxidative stress and apoptotic signaling, and recent studies have suggested that ...
Anna Migni +6 more
doaj +1 more source
DataSheet8_Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway.ZIP
, 2022 Aims: Cardiac lipotoxicity is the common consequence of lipid metabolism disorders in cardiomyocytes during development of heart failure (HF). Adenosine 5′monophosphate-activated protein kinase (AMPK) acts as an energy sensor and has a beneficial effect ...
Xue Tian (417237) +12 more
core +1 more source
A vicious circle between insulin resistance and inflammation in nonalcoholic fatty liver disease
Lipids in Health and Disease, 2017 Nonalcoholic fatty liver disease (NAFLD) comprises a spectrum of diseases, including simple steatosis, nonalcoholic steatohepatitis (NASH), liver cirrhosis and hepatocellular carcinoma.
Zhonge Chen +4 more
doaj +1 more source
DataSheet10_Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway.ZIP
, 2022 Aims: Cardiac lipotoxicity is the common consequence of lipid metabolism disorders in cardiomyocytes during development of heart failure (HF). Adenosine 5′monophosphate-activated protein kinase (AMPK) acts as an energy sensor and has a beneficial effect ...
Xue Tian (417237) +12 more
core +1 more source
Notoginsenoside R1 Ameliorates Cardiac Lipotoxicity Through AMPK Signaling Pathway
Frontiers in Pharmacology, 2022 Aims: Cardiac lipotoxicity is the common consequence of lipid metabolism disorders in cardiomyocytes during development of heart failure (HF). Adenosine 5′monophosphate-activated protein kinase (AMPK) acts as an energy sensor and has a beneficial effect ...
Xue Tian +18 more
doaj +1 more source
Type 2 Diabetes and Alzheimer’s Disease: The Emerging Role of Cellular Lipotoxicity
Biomolecules, 2023 Type 2 diabetes (T2D) and Alzheimer’s diseases (AD) represent major health issues that have reached alarming levels in the last decades. Although growing evidence demonstrates that AD is a significant comorbidity of T2D, and there is a ~1.4–2-fold ...
Nicola Marrano +10 more
doaj +1 more source